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Bionic natural vascular structure and functional multilayered double-orientation stent as well as preparation method of bionic natural vascular structure and functional multilayered double-orientation stent

A vascular structure and dual-orientation technology, which is applied in the direction of human tubular structure devices, blood vessels, etc., can solve the problems of difficulty in making stents of any diameter and length, low preparation efficiency, and limitations in diameter and stent length, so as to promote Effects of inward migration growth, simple preparation process and flexible method

Active Publication Date: 2019-05-03
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 1. These scaffolds are basically three-dimensional tubular scaffolds obtained directly based on electrospinning. It is not easy to inoculate cells evenly. There are also certain restrictions on the diameter and length of the scaffold, and the preparation efficiency is low.
[0007] 2. It is basically difficult for these stents to achieve a real bionic natural vascular structure, and it is difficult to guarantee the orientation of the stent
[0008] 3. The diameter and length of these stents cannot be changed at will, and it is difficult to make stents of any diameter and length

Method used

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  • Bionic natural vascular structure and functional multilayered double-orientation stent as well as preparation method of bionic natural vascular structure and functional multilayered double-orientation stent
  • Bionic natural vascular structure and functional multilayered double-orientation stent as well as preparation method of bionic natural vascular structure and functional multilayered double-orientation stent
  • Bionic natural vascular structure and functional multilayered double-orientation stent as well as preparation method of bionic natural vascular structure and functional multilayered double-orientation stent

Examples

Experimental program
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Effect test

Embodiment 1

[0041] Embodiment 1: A method for preparing a multi-layer dual-oriented stent that mimics the structure and function of natural blood vessels, the steps are as follows:

[0042] 1) dissolving poly(lactic-co-glycolic acid) and gelatin in trifluoroethanol at a mass ratio of 1:1, and magnetic stirring for 8 hours to prepare an electrospinning solution with a mass-volume ratio of 14%;

[0043] 2) if figure 1 As shown in A, fold the aluminum foil in half with the width direction as the axis, and get figure 1 B shape, then as in figure 1 As shown in C, the aluminum foil is crimped on the roller that fixes the aluminum foil along the width direction, the rotating speed of the control roller is 50rpm, and the electrospinning liquid is spun on one side of the aluminum foil by the electrospinning method (corresponding to the attached figure 1 abef side of D), prepare the first layer of fiber membrane without fiber orientation, such as figure 1 as shown in D;

[0044] 3) if figure ...

Embodiment 2

[0048] Embodiment 2: A method for preparing a bionic natural vascular structure and function multi-layer dual orientation stent, the steps are as follows:

[0049] 1) According to the principle of emulsion spinning, fibronectin and polyglycolic acid were dissolved in hexafluoroisopropanol at a mass ratio of 1:9, stirred for 8 hours, and a solution with a mass volume ratio of 15% was prepared, and then a small amount of polyglycolic acid was added. Ether F127, stirred evenly as the oil phase;

[0050] 2) dissolving 1 μg of vascular endothelial growth factor in 2% gelatin aqueous solution as the water phase, uniformly mixing the water phase and the oil phase with an oil-to-water ratio of 25:1 and stirring for 8 hours to obtain a uniformly emulsified electrospinning solution;

[0051] 3) if figure 1 As shown in A, fold the release paper in half with the width direction as the axis, and get figure 1 B shape, then as in figure 1 As shown in C, the release paper is curled on the ...

Embodiment 3

[0056] Embodiment 3: A method for preparing a multi-layer dual-oriented stent that mimics the structure and function of natural blood vessels, the steps are as follows:

[0057] 1) dissolving the poly(lactide caprolactone) copolymer in a mixed solution of dichloromethane and N,N-dimethylformamide (7:3 in volume ratio), and stirring for 10 hours to obtain an electrospinning solution;

[0058] 2) if figure 1 As shown in A, fold the oil paper in half with the width direction as the axis, and get figure 1 B shape, then as in figure 1 As shown in C, the oiled paper is curled on the roller that fixes the oiled paper along the width direction, the rotating speed of the roller is controlled to be 100 rpm, and the electrospinning liquid is spun on one side of the oiled paper by the electrospinning method to prepare the first fiber-free orientation. layer of fibrous membrane, such as figure 1 as shown in D;

[0059] 3) if figure 2 As shown in A-B, unfold the oiled paper, and then ...

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Abstract

The invention discloses a bionic natural vascular structure and a functional multilayered double-orientation stent as well as a preparation method of the bionic natural vascular structure and the functional multilayered double-orientation stent. The stent is manufactured from at least three layers of fiber films and medicines loaded on at least one of the fiber films; and the fiber orientation directions of the at least two layers of fiber films are different. The method disclosed by the invention is characterized in that based on nano-fibers prepared through electrostatic spinning, oriented or non-oriented fibers are obtained by curling a receiving film arranged on a roller receiving device; a specially-oriented nano-fiber film having a specific layer can be obtained through a method of folding and rotating the receiving film, and then the bionic natural vascular structure and the functional multilayered double-orientation stent are obtained through a special curling method. The vascular stent disclosed by the invention has the advantages that the bionic degree is high, cells are easily and uniformly inoculated, the preparation method is not limited by the diameter and the lengthof the stent, and the orientation of the stent is easily guaranteed, the preparation efficiency is high, and the cost is low.

Description

technical field [0001] The invention relates to a vascular stent and a preparation method thereof, in particular to a multilayer dual-orientation stent with bionic natural blood vessel structure and function and a preparation method thereof. Background technique [0002] With the development and progress of modern society, people's living standards have been significantly improved. However, cardiovascular disease, which is becoming more and more common, has become one of the serious threats that hinder the further improvement of people's quality of life, and it is also one of the main factors leading to high morbidity and mortality in modern society. Cardiovascular disease is reported to account for 30% of all deaths worldwide. In my country, death from cardiovascular disease has become the leading cause of death among urban and rural residents. At present, it is estimated that the number of patients with cardiovascular disease in my country is about 290 million, which is e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/06
Inventor 李龙李兴茂黄琳石雁
Owner GUIZHOU UNIV
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