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Application of activated notoginsenoside rich in rare ginsenoside in preparation of oral care products

A technology for ginsenosides and activation of Panax notoginseng, which is applied to medical preparations containing active ingredients, cosmetic preparations, oral care and other directions, can solve the problems of poor membrane permeability of Panax notoginseng saponins, difficulty in exerting medicinal effects, and poor human absorption. , to avoid discoloration, reduce bleeding gums, and promote periodontal health

Pending Publication Date: 2019-04-19
MINGCHEN HEALTH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, due to the poor permeability of the Panax notoginseng saponin membrane, it is poorly absorbed by the human body. It takes a long time to see a little effect, and the onset of effect is very slow. For the frail people, the intestinal absorption is even worse, and it is almost ineffective. Therefore, directly use Panax notoginseng or Protoginseng saponins are difficult to exert efficacy in oral care products

Method used

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  • Application of activated notoginsenoside rich in rare ginsenoside in preparation of oral care products
  • Application of activated notoginsenoside rich in rare ginsenoside in preparation of oral care products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] A toothpaste rich in activated notoginsenosides of rare ginsenosides, the weight percentage of each component is:

[0055] Rare ginsenoside-rich activated notoginseng saponin 0.1%, calcium carbonate 50%, polyethylene glycol 2%, sorbitol 18%, carmellose sodium 0.8%, xanthan gum 0.4%, sodium lauryl sulfate 2.5%, Cocamidopropyl Betaine 0.5%, Sodium Pyrophosphate 0.2%, Sodium Saccharin 0.25%, Methylparaben 0.15%, Propylparaben 0.05%, Fragrance 1.2%, Deionized water added to 100 %.

[0056] Among them, the raw material components in this example: the preparation process of activated notoginseng saponins rich in rare ginsenosides is as follows:

[0057] 1) Extract the total saponins of Panax notoginseng by using the root of Panax notoginseng as raw material: take the dried Panax notoginseng root, crush it, pass through a 100-mesh sieve, extract with 95% ethanol under reflux, filter, and concentrate the filtrate under reduced pressure to obtain the extract of Panax notoginsen...

Embodiment 2

[0068] A toothpaste rich in activated notoginsenosides of rare ginsenosides, the weight percentage of each component is:

[0069] Rare ginsenoside-rich activated notoginseng saponin 0.3%, calcium hydrogen phosphate 35%, silicon dioxide 5%, propylene glycol 5%, glycerin 10%, sorbitol 15%, sodium carboxymethylcellulose 0.5, guar gum 0.5 %, sodium lauryl sulfate 2.3%, sodium lauroyl sarcosinate 0.5%, sodium pyrophosphate 0.2%, sucralose 0.22%, sodium benzoate 0.3%, essence 1.0%, deionized water added to 100%.

[0070] Among them, the raw material components in this embodiment: the preparation process of activated notoginseng saponins rich in rare ginsenosides is as follows:

[0071] 1) Using the stems and leaves of Panax notoginseng as raw materials to extract the total saponins of Panax notoginseng: take the dried stems and leaves of Panax notoginseng, crush them, pass through a 100-mesh sieve, extract with 70% ethanol under reflux, filter, and concentrate the filtrate under red...

Embodiment 3

[0082] A toothpaste rich in activated notoginsenosides of rare ginsenosides, the weight percentage of each component is:

[0083] Rare ginsenoside-rich activated notoginseng saponin 0.5%, silicon dioxide 18%, polyethylene glycol 4%, sorbitol 56%, sodium carboxymethylcellulose 0.6, carrageenan 0.2%, sodium lauryl sulfate 2 %, sodium pyrophosphate 0.5%, aspartame 0.05%, stevia 0.05%, sodium benzoate 0.3%, essence 0.8%, titanium dioxide 0.2%, deionized water added to 100%.

[0084] Among them, the raw material components in this example: the preparation process of activated notoginseng saponins rich in rare ginsenosides is as follows:

[0085] 1) Extract the total saponins of Panax notoginseng by using the root of Panax notoginseng as raw material: take the dried Panax notoginseng root, crush it, pass through a 100-mesh sieve, extract with 80% ethanol under reflux, filter, and concentrate the filtrate under reduced pressure to obtain the extract of Panax notoginseng; Use supercr...

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Abstract

The invention discloses the application of activated notoginsenoside rich in rare ginsenoside in preparation of oral care products. The activated notoginsenoside rich in rare ginsenoside serves as anti-inflammatory, analgesic, anti-swelling and hemostatic components added into the oral care products such as toothpaste, mouthwash and toothpowder. According to the activated notoginsenoside rich in rare ginsenoside, the notoginsenoside is converted into rare ginsenoside through the biotechnology, and the activated notoginsenoside rich in rare ginsenoside can serve as anti-inflammatory, analgesic,anti-swelling and hemostatic components added into the oral care products. The oral care products can quickly alleviate gingival swelling, reduce gingival bleeding, reduce halitosis, help repair mucosal damage, promote periodontal health, better avoid different effects caused by individual metabolic differences, and the standardization of product functions is achieved.

Description

technical field [0001] The invention relates to the application of an activated notoginseng saponin rich in rare ginsenosides in the preparation of oral care products, and belongs to the technical field of oral care products. Background technique [0002] Panax notoginseng is the dry root of Panax notoginseng of Araliaceae, also known as Tianqi, Panax notoginseng, Panax notoginseng, Wenzhou notoginseng. Panax notoginseng is a traditional Chinese medicine in my country, which has pharmacological activities such as anti-inflammatory, hemostatic, anti-aging, and anti-tumor. The main active ingredient of Panax notoginseng is Panax notoginseng saponin, and more than 70 kinds of saponins have been isolated from different parts of Panax notoginseng, which are divided into tetracyclic triterpene dammarane type protopanaxadiol group saponins and tetracyclic triterpene dammarane type Protopanaxatriol group saponins. The pharmacological effects of each monomer saponin in Panax notogi...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P29/00A61P7/04A61P1/02A61K8/9789A61Q11/00
CPCA61K36/258A61K2236/19A61K2236/333A61K2236/37A61K2236/55A61Q11/00A61K8/9789A61P1/02A61P7/04A61P29/00
Inventor 葛华亭李莉陈秀丹崔凤玲蚁永腾施煜林椰林天贤
Owner MINGCHEN HEALTH CO LTD
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