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Coating method for activated carbon adsorbent for blood perfusion

A technology of activated carbon adsorption and hemoperfusion, which is applied in the direction of blood circulation treatment, chemical instruments and methods, suction devices, etc., can solve the problems of poor blood compatibility of adsorbents and particle shedding, so as to improve anticoagulant performance, reduce coagulation, The effect of reducing shedding

Inactive Publication Date: 2019-04-16
重庆希尔康血液净化器材研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The technical problem to be solved is: coating the activated carbon adsorbent for hemoperfusion, solving the problems of poor hemocompatibility and particle shedding of the adsorbent, and at the same time improving the anticoagulant performance of the adsorbent

Method used

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  • Coating method for activated carbon adsorbent for blood perfusion

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Effect test

Embodiment 1

[0025] A coating method of activated carbon adsorbent for hemoperfusion uses spherical resin carbon as raw material, comprising the following steps:

[0026] Step 1: Coating, disperse 4.5g chitosan in 150ml purified water, then add glacial acetic acid according to the mass concentration of 3%, stir to completely dissolve chitosan; then 100ml resin carbon, stir for 2 hours to make chitosan on the surface of resin carbon full adsorption;

[0027] Step 2: collect activated carbon by filtration, wash activated carbon with 0.5mol / L sodium hydroxide solution to remove acetic acid.

[0028] Step 3: Cross-linking, dissolve 0.15mol of epichlorohydrin in 150ml of sodium hydroxide solution (PH=10), then add the activated carbon treated in step 1, and stir at 40°C for 4h;

[0029] Step 4: Collect activated carbon by filtration, wash with absolute ethanol to remove epichlorohydrin, and then use purified water to activate carbon until the washing liquid is neutral.

[0030] Step:5: Graft ...

Embodiment 2

[0033] A coating method of activated carbon adsorbent for hemoperfusion uses spherical resin carbon as raw material, comprising the following steps:

[0034] Step 1: Coating, disperse 6.0g chitosan in 150ml purified water, then add glacial acetic acid according to the mass concentration of 3%, stir to completely dissolve chitosan; then 100ml resin carbon, stir for 2 hours to make chitosan on the surface of resin carbon full adsorption;

[0035] Step 2: collect activated carbon by filtration, wash activated carbon with 0.5mol / L sodium hydroxide solution to remove acetic acid.

[0036] Step 3: Cross-linking, dissolve 0.15mol of epichlorohydrin in 150ml of sodium hydroxide solution (PH=10), then add the activated carbon treated in step 1, and stir at 50°C for 4h;

[0037] Step 4: Collect activated carbon by filtration, wash with absolute ethanol to remove epichlorohydrin, and then use purified water to activate carbon until the washing liquid is neutral.

[0038] Step: 5: Graft...

Embodiment 3

[0041] A coating method of activated carbon adsorbent for hemoperfusion uses spherical resin carbon as raw material, comprising the following steps:

[0042] Step 1: Coating, disperse 7.5g chitosan in 150ml purified water, then add glacial acetic acid according to the mass concentration of 3%, stir to completely dissolve chitosan; then 100ml resin carbon, stir for 2 hours to make chitosan on the surface of resin carbon full adsorption;

[0043] Step 2: collect activated carbon by filtration, wash activated carbon with 0.5mol / L sodium hydroxide solution to remove acetic acid.

[0044] Step 3: Cross-linking, dissolve 0.15mol of epichlorohydrin in 150ml of sodium hydroxide solution (PH=10), then add the activated carbon treated in step 1, and stir at 60°C for 4h;

[0045] Step 4: Collect activated carbon by filtration, wash with absolute ethanol to remove epichlorohydrin, and then use purified water to activate carbon until the washing liquid is neutral.

[0046] Step:5: Graft ...

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Abstract

The invention provides a coating method for an activated carbon adsorbent for blood perfusion. Firstly, coating film is formed on the surface of activated carbon with chitosan, then crosslinking is executed with epichlorohydrin to increase the strength of the film, and finally heparin sodium having an anticoagulant effect is grafted to the surface of the film. The crosslinked chitosan film can improve the blood compatibility of the activated carbon and decrease particle falling of the activated carbon; the heparin sodium having an excellent anticoagulant property is grafted on the film so thatthe blood coagulation phenomenon occurring when blood is in contact with the surface of the activated carbon can be decreased, and the safety of a perfusion device is improved.

Description

technical field [0001] The invention relates to a coating method of an activated carbon adsorbent for hemoperfusion, which belongs to the field of hemoperfusion, and in particular to a method for improving the anticoagulant function of the activated carbon adsorbent. Background technique [0002] Activated carbon is a broad-spectrum adsorbent with high porosity and high specific surface area. Its precursor is made by carbonization at high temperature. It has a single composition and good chemical stability. Activated carbon in hemoperfusion can adsorb various chemical substances, especially for drugs and poisons, and has a high clearance rate, but its blood compatibility is poor, and the shedding of particles will cause embolism. Therefore, scientific researchers coated activated carbon with polymer materials with good blood compatibility, which solved the problems of poor blood compatibility of activated carbon adsorbents and shedding of tiny carbon particles, and effective...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/24B01J20/28B01J20/30A61M1/36
CPCA61M1/3621A61M1/3672A61M1/3687B01J20/20B01J20/22B01J20/24B01J20/28011
Inventor 邹玲玲罗章凯张文
Owner 重庆希尔康血液净化器材研发有限公司
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