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Hydrogel for repairing endometrium injury and preparation method thereof

A technology for repairing endometrium and damage, applied in medical science, prostheses, etc., to achieve the effects of ensuring no loss, reducing immunogenicity, and ensuring slow release and long-term effects

Active Publication Date: 2019-04-05
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is still a lack of an endometrial injury repair preparation that can meet the above requirements at the same time

Method used

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  • Hydrogel for repairing endometrium injury and preparation method thereof
  • Hydrogel for repairing endometrium injury and preparation method thereof
  • Hydrogel for repairing endometrium injury and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Preparation of Hydrogel for Endometrial Damage Repair

[0020] Preparation method 1: According to the composition of each experimental group of hydrogel for repairing endometrial damage in Table 1, weigh each component, and crush the endometrial decellularized matrix according to the aseptic method, which has a high affinity with heparin Mix the heparin-poloxamer gel of sex cell growth factor, add the aminated aloe polysaccharide-glyceraldehyde gel and mix, add vitamin C and mix to form a uniform semi-solid gel.

[0021] Preparation method 2: According to the composition of each experimental group of hydrogel for repairing endometrial damage in Table 1, weigh each component, crush the endometrial decellularized matrix according to the aseptic method, and mix with aminated aloe polysaccharide-glycerin The aldehyde gel was mixed evenly, and heparin-poloxamer gel loaded with heparin high-affinity cell growth factor was added to mix evenly, and vitamin C was added...

Embodiment 2

[0030] Example 2 In vivo evaluation of the application effect of endometrial damage repair hydrogel in each group

[0031] (1) Rat endometrial injury animal model

[0032]The rat model of mechanical endometrial injury was constructed by mechanical curettage. The method was as follows: in a sterile operating room, SPF female SD rats weighing 250-300g were taken, and the vaginal smears of the rats were observed daily, and they were in estrus Female mice were used for model construction. Experimental rats were anesthetized with 10% chloral hydrate, sterilized the lower abdomen with 75% alcohol, cut the skin 1 cm above the urethra and entered the abdominal cavity to expose the uterus, made an incision on the right Y-shaped 1 / 3 of the uterus, and used a self-made scraper. The endometrium was scraped off with a spoon to simulate clinical endometrial curettage, causing pathological endometrial damage, and the surgical incision was sutured after surgery. After the rats recovered fro...

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Abstract

The invention provides hydrogel for repairing endometrium injury. The hydrogel is prepared from amination aloe polysaccharide-glyceraldehyde gel, heparin-poloxamer gel containing heparin high-affinitycytokines, and an endometrial acellular matrix, and the mechanical strength and the degradation rate of the hydrogel for repairing endometrium injury are controlled by changing the component ratio. The hydrogel for repairing endometrium injury has low immunogenicity and multiple advantages such as rapid endometrium repair, provides the optimal physicochemical and biological microenvironments forendometrium repair, effectively guides cell directional arrangement, has good mechanical properties, and rapidly repairs endometrium injury.

Description

technical field [0001] The invention relates to a hydrogel for repairing endometrial damage, in particular to the composition, preparation and application of a hydrogel for repairing endometrial damage. Background technique [0002] The uterus is the place where menstruation occurs and the fetus is conceived. The normal endometrium can repair and regenerate itself, and plays a pivotal role in female physiological and reproductive functions. However, serious endocrine disorders, intrauterine infection, and uterine surgery can cause endometrial damage, thereby destroying the normal structure of the endometrium. Once the basal layer of the endometrium is damaged, the regeneration of epithelial and mesenchymal cells will be impaired, the formation of new blood vessels will be damaged, and the self-repair function of the endometrium will be seriously affected. When the uterine cavity lacks endometrial coverage, fibrosis, scarring, and adhesions may occur on the anterior and post...

Claims

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Application Information

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IPC IPC(8): A61L27/52A61L27/36A61L27/20A61L27/18A61L27/54
CPCA61L27/18A61L27/20A61L27/3633A61L27/52A61L27/54A61L2300/414A61L2300/604C08L5/10C08L71/02C08L5/00
Inventor 赵应征鲁翠涛姚情徐荷林郑雅文林蒙婷江雪
Owner WENZHOU MEDICAL UNIV
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