A kind of natural polysaccharide-based medical antibacterial hydrocolloid dressing and preparation method thereof

A natural polysaccharide and antibacterial water technology, applied in the field of medical supplies, can solve problems such as unsatisfactory effects, achieve good skin adhesion strength, high liquid absorption rate, and not easy to fall off

Active Publication Date: 2020-09-25
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect is not ideal when used on wounds with potential infection risk or already infected

Method used

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  • A kind of natural polysaccharide-based medical antibacterial hydrocolloid dressing and preparation method thereof
  • A kind of natural polysaccharide-based medical antibacterial hydrocolloid dressing and preparation method thereof
  • A kind of natural polysaccharide-based medical antibacterial hydrocolloid dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Put 10 parts of styrene-ethylene-butylene-styrene block copolymer (SEBS-YH-506), 2 parts of hyaluronic acid (molecular weight 500,000 Daltons) and 1 part of cobalt chloride at a speed of 200r / min in the internal mixer, knead at 160°C for 30 min, cool to room temperature to obtain a hydrocolloid layer; cut the polyurethane film into the size of the mold, and apply the above hydrocolloid layer on the polyurethane film in the groove of the mold, covering Glassine paper was punched and formed at 160°C and 10MPa to obtain a hydrocolloid dressing.

Embodiment 2

[0028] Place 5 parts of styrene-isoprene-styrene block copolymer (SIS-YH-1126), 2 parts of carboxylated chitosan (molecular weight 200,000 Daltons) and 4 parts of zinc chloride at a speed of In a 150r / min internal mixer, knead at 150°C for 60 minutes, cool to room temperature to obtain a hydrocolloid layer; cut the polyurethane film into the size of the mold, and apply the above hydrocolloid layer on the polyurethane film in the groove of the mold , covered with glassine paper, punched and formed at 160° C. and 10 MPa to obtain a hydrocolloid dressing.

Embodiment 3

[0030] Put 8 parts of EPDM rubber (EPDM-X-3042E), 4 parts of carboxylated starch (molecular weight 1,000,000 Daltons) and 4 parts of ferric chloride into an internal mixer with a rotation speed of 200r / min. Mix at 150°C for 5 minutes, cool to room temperature to obtain a hydrocolloid layer; cut the polyurethane film into the size of the mold, and in the groove of the mold, apply the above hydrocolloid layer on the polyurethane film, cover with glassine paper, at 150°C, Stamping under 10MPa to obtain hydrocolloid dressing.

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Abstract

The invention discloses a natural polysaccharide-based medical antibacterial hydrocolloid dressing. The natural polysaccharide-based medical antibacterial hydrocolloid dressing consists of a back lining support layer, a hydrocolloid layer and a stripping layer, wherein the hydrocolloid layer consists of a thermoplasticity elasticity body, natural polysaccharide and a cross-linking agent. The hydrocolloid dressing has favorable comfortable degree and adhesion strength to skin, the extensibility is 1.5N / cm-3N / cm, the permanent deformation is smaller than or equal to 1%, the extensibility of thedressing is close to extensibility of normal skin, and favorable comfortable degree can be provided. The stripping strength is 4N / cm-5N / cm, the imbibing multiplying power of the hydrocolloid is greater than or equal to 18 times, the water retention time is greater than or equal to 48 hours, the water vapor transmission is 20g.m<-2>.24h<-1>, and the dressing has favorable antibiotic action on common staphylococcus aureus and escherichia coli. Besides, the dressing is high in biocompatibility, can effectively prevent infection of wounds, and besides, can be used for infected wounds.

Description

technical field [0001] The invention belongs to the field of medical supplies, and relates to a natural polysaccharide-based medical antibacterial hydrocolloid dressing and a preparation method thereof. Background technique [0002] Hydrocolloid dressing is a new type of wound care dressing, which can be adapted to various tissue exudative wounds in clinic. Compared with traditional dressings, hydrocolloid dressings have the following advantages: 1. It can maintain the moist microenvironment of the wound surface for a long time and promote the healing of the wound surface; 2. It can continuously absorb exudate, reduce the frequency of dressing changes, and reduce the damage caused by dressing changes. 3. Completely cover the wound surface, isolate bacteria, and reduce the risk of wound infection. [0003] At present, traditional hydrocolloid dressings are mostly prepared by blending cellulose and rubber materials. The dispersed blended cellulose provides water absorption pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F13/02A61L15/28A61L15/26A61L15/24A61L15/46A61L15/42
CPCA61F13/00063A61F13/0213A61F13/0253A61F13/0289A61L15/24A61L15/26A61L15/28A61L15/42A61L15/46C08L5/08C08L5/04C08L75/04C08L77/00C08L23/16C08L53/02
Inventor 徐福建张想宋洁李杨
Owner BEIJING UNIV OF CHEM TECH
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