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3D-printable high-strength temperature-sensitive supramolecular hydrogel and preparation method thereof

A supramolecular hydrogel, 3D printing technology, applied in the direction of additive processing, can solve the problems of reducing the fidelity of the scaffold, easy to collapse, reducing the load cells, etc., and achieve the effect of favorable shape fidelity

Active Publication Date: 2019-03-15
TIANJIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it is easy to collapse before cross-linking, which reduces the fidelity of the scaffold, and post-cross-linking greatly reduces the survival rate of loaded cells and factors.

Method used

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  • 3D-printable high-strength temperature-sensitive supramolecular hydrogel and preparation method thereof
  • 3D-printable high-strength temperature-sensitive supramolecular hydrogel and preparation method thereof
  • 3D-printable high-strength temperature-sensitive supramolecular hydrogel and preparation method thereof

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Embodiment Construction

[0017] The technical solutions of the present invention will be further described below in conjunction with specific embodiments.

[0018] Synthesize copolymerized gels with different total monomer concentrations and different monomer mass ratios in the examples. The monomer concentration is 30%, and the mass ratio of acryloyl glycinamide and N-acryloyl (trimethylol) aminomethane is 5:1 as an example, where the monomer concentration refers to the sum of the mass of acryloyl glycinamide monomer and N-acryloyl (trimethylol) aminomethane monomer and the total mass of the two monomers and water ratio. Add 250 mg of acryloyl glycinamide monomer and 50 mg of N-acryloyl (trimethylol) aminomethane monomer into 1000 μL of deionized water, and add photoinitiator Irgacure 1173 (2-hydroxy-2 -methyl-1-phenyl-1-propanone) 9 μL. After the mixed solution is filled with nitrogen to remove oxygen, the mixed solution is injected into a closed mold, and the mold is irradiated in a UV curing box...

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Abstract

The invention discloses a 3D-printable high-strength temperature-sensitive supramolecular hydrogel and a preparation method thereof. The preparation method comprises the following steps: firstly, using acryloyl glycinamide and N-[2-hydroxy-1, 1-bis(hydroxymethyl)ethyl]acrylamide as raw materials; and then, polymerizing with radicals to prepare copolymer gels different in monitor concentration in the presence of an initiator. The hydrogel provided by the invention can have different properties by changing a total monomer concentration or adjusting a mass ratio of two monomers, can be molten toflow at a high temperature, and has a characteristic of shear thinning; and a simple and feasible method for preparing 3D-printable high-strength temperature-sensitive supramolecular hydrogel is realized in the invention.

Description

technical field [0001] The invention belongs to the technical field of hydrogels, and relates to a 3D printable hydrogel and a preparation method thereof, more specifically, relates to a hydrogel with acryloyl glycinamide and N-acryloyl (trimethylol) aminomethane The copolymerized supramolecular hydrogel prepared from a monomer and its preparation method have the functions of good stability at room temperature, good strength, temperature sensitivity and 3D printing. Background technique [0002] Hydrogel is a polymer material with cross-linked structure, which is hydrophilic but water-insoluble and can absorb a large amount of water (usually the water content is greater than 50% of the total mass) with water as the dispersion medium. Because of the physical crosslinking and chemical crosslinking between polymer chains, it will not dissolve in water, but can only swell and maintain a certain shape. At the same time, it also has good water permeability and biocompatibility. It...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/60C08F220/58C08J3/075
CPCB33Y70/00C08F220/60C08J3/075C08J2333/24C08F220/603C08F220/58
Inventor 刘文广高飞
Owner TIANJIN UNIV
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