3D printing high strength temperature-sensitive supermolecular hydrogel stent for bone repair

Abstract

The invention discloses a 3D printing high strength temperature-sensitive supermolecular hydrogel stent for bone repair. The hydrogel is prepared by the following steps: first, taking acroloyl glycinamide and N-acroloyl (trihydroxymethyl) amino methane as a raw material; in the presence of an initiator, carrying out free radical polymerization to prepare copolymerized gels of different monomer concentrations. The hydrogel has different properties by changing the general monomer concentration or adjusting the mass ratio of two monomers, can be melted and flow at a high temperature, and has thecharacteristics of shear thinning. After the hydrogel is melted, tricalcium phosphate nanoparticles are blended to prepare the porous stent by means of a 3D printing technology. The hydrogel is simplein formula, safe in component and mild in preparation condition. The obtained ink is proper in viscosity and suitable for continuously extruded 3D printing. The bone repair stent constructed based onthe 3D printing slurry is safe and stable.

Description

technical field [0001] The invention belongs to the technical field of hydrogels, and relates to a 3D printable hydrogel and a preparation method thereof, more specifically, relates to a hydrogel with acryloyl glycinamide and N-acryloyl (trimethylol) aminomethane Preparation of copolymeric supramolecular hydrogel for monomer and its preparation method for bone repair scaffold, this hydrogel has good stability at room temperature, good strength, temperature sensitivity and 3D printable function, and tricalcium phosphate The particle (β-TCP) is mixed in a simple way, which endows the scaffold with good osteoinductivity and osteoconductivity. Background technique [0002] Hydrogel is a polymer material with cross-linked structure, which is hydrophilic but water-insoluble and can absorb a large amount of water (usually the water content is greater than 50% of the total mass) with water as the dispersion medium. Because of the physical crosslinking and chemical crosslinking betw...

AI Technical Summary

Problems solved by technology

However, the growth factor itself has problems such as short half-life, easy inactivation, high price and risk of side effects, and the subsequent sterilization and storage of growth factor-loaded scaffolds are also difficult

Growth factors usually can only be loaded on the surface of the scaffold in a specific way after the scaffold is formed, and the process is complex and cumbersome

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