Electrified repair film material controllable in surface potential and preparation method thereof

A charged repair and surface potential technology, which is applied in the fields of pharmaceutical formulations, prostheses, drug delivery, etc., can solve the problems of inability to adapt to the physiological electric microenvironment, the uncontrollable surface potential of materials, and the limited repair effect of materials, etc., to achieve good bone health. Defect repair effect, good bone repair effect, stable product effect

Active Publication Date: 2019-03-12
PEKING UNIV SCHOOL OF STOMATOLOGY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the technical problems that the surface potential of existing materials cannot be adjusted, cannot be adapted to the physiological electrical microenvironment of each tissue defect, and the repair effect of the material is limited, and provides a charged repair membrane material with controllable surface potential and its preparation method

Method used

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  • Electrified repair film material controllable in surface potential and preparation method thereof
  • Electrified repair film material controllable in surface potential and preparation method thereof
  • Electrified repair film material controllable in surface potential and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Weigh 2g of polymer P(VDF-TrFE), add it to 20ml of nitrogen-nitrogen dimethylformamide, make the concentration of the polymer solution 0.1g / ml, place it on a magnetic stirrer and stir for 6h, and make the polymer Uniformly dissolved and dispersed in an organic solvent to obtain a ferroelectric polymer solution;

[0027] (2) casting the mixed solution obtained in step (1) in a casting machine, and drying the film obtained by casting at a temperature of 55° C. to obtain a polymer film material with a film thickness of 70 μm;

[0028] (3) annealing the film material obtained in step (2), the annealing temperature is 140°C, and the annealing time is 1h;

[0029] (4) The film material obtained in step (3) is subjected to polarization treatment, the polarization voltage is 20kV, the polarization distance is 15mm, the polarization temperature is 25°C, and the polarization time is 30min to obtain a charged surface with a high surface potential. bioremediation membrane mate...

Embodiment 2

[0031] (1) Weigh 2g of polymer P(VDF-TrFE), add it to 20ml organic solvent nitrogen nitrogen dimethylformamide, make the polymer solution concentration 0.1g / ml, place it on a magnetic stirrer and stir for 6h, make The polymer is uniformly dissolved and dispersed in an organic solvent to obtain a ferroelectric polymer solution;

[0032] (2) casting the mixed solution obtained in step (1) in a casting machine, and drying the film obtained by casting at a temperature of 55° C. to obtain a polymer film material with a film thickness of 70 μm;

[0033] (3) annealing the film material obtained in step (2), the annealing temperature is 40°C, and the annealing time is 1h;

[0034] (4) The thin film material obtained in step (3) is subjected to polarization treatment, the polarization voltage is 12kV, the polarization distance is 25mm, the polarization temperature is 25°C, and the polarization time is 30min, so as to obtain a charged bioremediation with a low surface potential membran...

Embodiment 3

[0036] (1) Weigh 2g of polymer P(VDF-TrFE), add it to 20ml organic solvent nitrogen nitrogen dimethylformamide, make the polymer solution concentration 0.1g / ml, place it on a magnetic stirrer and stir for 6h, make The polymer is uniformly dissolved and dispersed in an organic solvent to obtain a ferroelectric polymer solution;

[0037] (2) casting the mixed solution obtained in step (1) in a casting machine, and drying the film obtained by casting at a temperature of 55° C. to obtain a polymer film material with a film thickness of 70 μm;

[0038] (3) annealing the thin film material obtained in step (2), the annealing temperature is 90°C, and the annealing time is 1h;

[0039] (4) The thin film material obtained in step (3) is subjected to polarization treatment, the polarization voltage is 16kV, the polarization distance is 20mm, the polarization temperature is 25°C, and the polarization time is 30min, to obtain a charged bioremediation with a medium potential on the surface...

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Abstract

The invention relates to an electrified repair film material controllable in surface potential and solves the technical problem that existing materials are not adjustable in surface potential, cannotbe adapted to electrophysiological microenvironment of each tissue defective position and limited in material repair effect. The electrified repair film material is a thin-film-shaped material prepared from ferroelectric high-molecular polymer and an organic solvent. The invention further provides a preparation method of the electrified repair film material. The electrified repair film material can be widely applied in the technical field of surgical implanting of bionic electrified microenvironment repair materials.

Description

technical field [0001] The invention relates to the technical field of surgically implanted bionic charged microenvironment repair materials, in particular to a charged repair film material with controllable surface potential and a preparation method thereof. Background technique [0002] The use of surgical implant materials for defect repair is one of the commonly used clinical methods. With the improvement of people's living standards, the number of tissue defect cases caused by trauma, disease and other reasons has gradually increased. Artificial charged implant repair materials have a wide range of sources, The advantages of relatively low cost and mild immune rejection have attracted extensive attention from researchers. According to research reports, there are different physiological electrical microenvironments in various tissues of the human body, and when the tissue is damaged, its physiological electrical microenvironment is also changed accordingly. How to promo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/16A61L27/38A61L27/54
CPCA61L27/16A61L27/3834A61L27/50A61L27/54A61L2300/412A61L2430/02A61L2400/18C08L27/16
Inventor 刘雯雯邓旭亮张冯依
Owner PEKING UNIV SCHOOL OF STOMATOLOGY
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