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A new benzofuran methyl ketone compound with anti-gastric cancer effect and its extraction and separation method

A technology of benzofuran methyl ketone type and separation method is applied in the fields of preparation of anti-gastric cancer drugs, separation and extraction of benzofuran methyl ketone type compounds, which can solve the problems of weak pharmacological activity and the like, and achieve inhibition of vascular endothelial growth factor. and transfer growth factor-β, the effect of inhibiting the proliferation of AGS cells

Active Publication Date: 2021-06-04
大连五舟神草健康科技有限公司
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Problems solved by technology

But the separation and the pharmacological activity research of the new compound of Malachite in the present application have not been reported, the chemical composition majority that separates from Malachite is known at present, and pharmacological activity is relatively weak, therefore, to new compound in Malachite The development and separation of

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  • A new benzofuran methyl ketone compound with anti-gastric cancer effect and its extraction and separation method
  • A new benzofuran methyl ketone compound with anti-gastric cancer effect and its extraction and separation method
  • A new benzofuran methyl ketone compound with anti-gastric cancer effect and its extraction and separation method

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Embodiment Construction

[0025] The invention provides a new benzofuran methyl ketone type compound, the molecular formula is C 19 h 24 o 9 , the chemical structure is as figure 1 .

[0026] The new benzofuran methyl ketone compound is named 2-(5-acetyl-6-hydroxyl-2,3-dihydrobenzofuran-2 base)-propenyl-1- O - β - D -Glucopyranoside (2-(5-acetyl-6-hydroxy-2,3-dihydrobenzofuran-2-yl)-propenyl-1- O - β - D -glucopyranoside), Table 1. For the benzofuran methyl ketone compound in CD 3 OD is the NMR data of the test solvent (see Figure 2-6 ).

[0027]

[0028] 1. A method for extracting and separating benzofuran methyl ketone compounds.

[0029] Step 1: Weigh 10 kg of dry medicinal material of Malacock Herba, extract with 30-75% ethanol water, preferably ethanol-water (60:40) reflux extraction; according to the weight ratio of the medicinal material powder of Malacock Herb and the ethanol aqueous solution of the solvent: 1.0: 8-15 extraction, preferably 1.0:10 extraction; heating and reflux...

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Abstract

The invention relates to the field of extraction and separation of active ingredients of traditional Chinese medicine, in particular to a new benzofuran methyl ketone compound with the molecular formula C 19 h 24 o 9 , named 2-(5-acetyl-6-hydroxy-2,3-dihydrobenzofuran-2-yl)-propenyl-1- O - β - D ‑Glucopyranoside (2‑(5‑acetyl‑6‑hydroxy‑2,3‑dihydrobenzofuran‑2‑yl)‑propenyl‑1‑ O - β - D ‑glucopyranoside). The present invention also provides a new extraction and separation method of benzofuran methyl ketone compound, which uses ethanol extraction, macroporous adsorption resin, MCI GEL column, and preparation of liquid phase separation in sequence to extract and separate new benzofuran methyl ketones simply and quickly. The furan methyl ketone type compound has anti-gastric cancer effect and can be used for developing and developing anti-gastric cancer drugs.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to the extraction and separation of a new benzofuran methyl ketone compound in malachite traditional Chinese medicine and its use in the preparation of anti-gastric cancer drugs. Background technique [0002] peacock grass ( Tagetes patula L.), also known as red yellow grass, rattan chrysanthemum, and small marigold, is a plant of the genus Marigold in the family Asteraceae and is an annual herb. It is cultivated all over our country and is a common ornamental flower. Peacock grass has medicinal and health care functions. The flowers and leaves can be used as medicine. Can treat whooping cough, bronchitis, cold and other diseases. [0003] Since the 1980s, people began to study the chemical constituents of Malachite, and isolated flavonoids such as patuletin, quercetagetin, and quercetagitrin. And isolated in the root to obtain α-tertiary thiophene. 5-(4-Ac...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/04C07H1/08A61P35/00
CPCA61P35/00C07H1/08C07H17/04
Inventor 窦德强冉小库王宇萌蔡德成
Owner 大连五舟神草健康科技有限公司
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