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Method for preparing porous polymer micro needle by using template method and application thereof

A technology of porous polymer and template method, which is applied in the direction of microneedles, medical devices, needles, etc., can solve the problems of complex preparation process of porous polymer microneedles, difficulties in large-scale production and application, and difficult to control the size. The effect of uniform size distribution, adjustable porosity and regular pore structure

Inactive Publication Date: 2019-02-22
HUAZHONG UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above defects or improvement needs of the prior art, the object of the present invention is to provide a method for preparing porous polymer microneedles by a template method and its application, wherein the overall process design of the preparation method is improved, and the key Conditions and parameters (such as the size of the template and the mass ratio of the template to the polymer, etc.) are optimized, and porous polymer microneedles can be prepared on a large scale through a simple template method, which can solve the problem of porous polymer microneedle preparation process Complexity, harsh conditions, cumbersome process, high price, difficult control of pore structure and size, and difficulties in large-scale production and application, the resulting porous polymer microneedles can be used in tissue fluid extraction and transdermal drug delivery, such as skin tissue fluid, Blood extraction and transdermal administration of proteins, polypeptides and small molecule drugs in applications such as cosmetology, hair growth, immunity, and treatment; and, the present invention also preferably regulates the size and content of the template agent, thereby regulating the porous polymerization The pore size and porosity of the physical microneedles make the prepared porous polymer microneedles have a porous structure with tunable pore size and porosity

Method used

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  • Method for preparing porous polymer micro needle by using template method and application thereof
  • Method for preparing porous polymer micro needle by using template method and application thereof
  • Method for preparing porous polymer micro needle by using template method and application thereof

Examples

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Effect test

Embodiment 1

[0051] A porous polymer microneedle array prepared by a template method is prepared as follows: first, a polytetrafluoroethylene negative mold is prepared by laser etching; then, polyvinylidene fluoride and calcium carbonate with a size of 500nm A mass ratio of 7 is added to dimethyl sulfoxide to be configured into a solution, and the above solution is added dropwise to the polytetrafluoroethylene negative mold, and vacuuming promotes the solution to enter the mould; heating and drying dimethyl sulfoxide, peeling off to obtain Solid polyvinylidene fluoride microneedles containing calcium carbonate; the obtained solid microneedles are placed in 2mol / L dilute nitric acid solution to remove calcium carbonate nanoparticles to obtain porous polyvinylidene fluoride microneedles.

Embodiment 2

[0053] A porous polymer microneedle array prepared by a template method is prepared according to the following method: first, a PDMS negative mold is prepared by a microtemplate method; then, polysulfone and calcium carbonate with a size of 2 μm are added in a mass ratio of 3:7 Prepare a solution in dimethyl sulfoxide, drop the above solution onto the PDMS negative mold, and ultrasonically promote the solution to enter the mold; dry the dimethyl sulfoxide, and peel off to obtain solid polysulfone microneedles containing calcium carbonate; The obtained solid microneedles are placed in 2mol / L dilute nitric acid solution, and the calcium carbonate nanoparticles are removed to obtain porous polysulfone microneedles.

Embodiment 3

[0055] A porous polymer microneedle array prepared by a template method is prepared as follows: first, a stainless steel negative mold is prepared by micro-electromechanical processing technology; then, polysulfone and sodium chloride with a size of 50 μm are mixed in a mass ratio of 3:7 Add the solution to N-methylpyrrolidone to form a solution, add the above solution dropwise to the stainless steel female mold, and vacuumize to promote the solution into the mold; heat and dry N-methylpyrrolidone, and peel off to obtain a solid polymer containing sodium chloride. Sulfone microneedles; the obtained solid microneedles are placed in pure water to remove sodium chloride to obtain porous polysulfone microneedles.

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Abstract

The invention discloses a method for preparing a porous polymer micro needle by using a template method and an application thereof. The method comprises the following steps of: (1) dissolving a polymer and a template agent in a solvent to prepare a polymer solution; (2) filling the polymer solution into a micro needle mould; (3) removing the solvent in the obtained micro needle mould to obtain a solid micro needle; (4) removing the template agent in the obtained solid micro needle to obtain the porous polymer micro needle. By improving the overall process flow design of the preparation method,the method can solve the technical problems of a complex preparation process, harsh conditions, a complicated process, high price, difficult control of the pore structure and size, difficult large-scale production and application and the like of the porous polymer micro needle, the obtained porous polymer micro needle can be used for tissue fluid extraction and transdermal administration, such asskin tissue fluid and blood extraction and transdermal administration of proteins, polypeptides and small molecular drugs in cosmetic, hair growth, immunity, treatment and other applications.

Description

technical field [0001] The invention belongs to the field of biomedical polymer materials, and more specifically relates to a method for preparing a porous polymer microneedle by a template method and its application. The porous polymer microneedle obtained by the method can be used to extract interstitial fluid or blood preparations Or prepare pharmaceutical preparations for transdermal administration. Background technique [0002] Microneedles are three-dimensional array structures made of silicon, metal, and polymers with a length of 25–2000 μm and tapered tips. Microneedle is a new type of minimally invasive drug delivery tool in the field of biomedicine, which can enhance the effect of skin drug delivery through the epidermis and dermis of the skin. In recent years, microneedles have attracted widespread attention in the field of transdermal drug delivery due to their advantages of high efficiency, safety, and painlessness. [0003] Porous microneedles are usually thr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00C08L27/16C08L81/06C08L1/12C08L71/02C08K3/26C08K3/16C08K3/22C08K3/36C08J9/26
CPCA61M37/0015A61M2037/0023A61M2037/0046A61M2037/0053C08J9/26C08J2201/044C08J2201/0442C08J2201/0444C08J2201/0446C08J2301/12C08J2327/16C08J2371/02C08J2381/06C08J2401/12C08J2471/02C08K3/16C08K3/36C08K2003/2206C08K2003/265A61K9/0021C08J2201/042C08J2205/044C08J2207/10
Inventor 朱锦涛柳佩李钰策康红杰张连斌王华杜虹瑶陶娟
Owner HUAZHONG UNIV OF SCI & TECH
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