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Surface modified polyarylether bone implant material containing phthalazinone biphenyl structure and preparation method thereof

A naphthalenone biphenyl and surface modification technology, which is used in pharmaceutical formulations, coatings, pharmaceutical sciences, etc., can solve the problems of poor surface coating stability, affecting the life of PEEK implants, and low biocompatibility.

Active Publication Date: 2019-02-22
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, problems such as low biocompatibility and unsatisfactory osteogenic activity have always affected the life of PEEK implants. In order to improve these problems of the material, researchers modified the surface of PEEK and prepared bone-like phosphorus on the surface. Limestone coating with osteogenic protein layer for enhanced biocompatibility and osteogenic activity
[0005] The existing polyarylether bone implant materials all have problems such as poor surface coating stability, so there is an urgent need for a bone implant material with good surface coating stability and long service life

Method used

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  • Surface modified polyarylether bone implant material containing phthalazinone biphenyl structure and preparation method thereof
  • Surface modified polyarylether bone implant material containing phthalazinone biphenyl structure and preparation method thereof
  • Surface modified polyarylether bone implant material containing phthalazinone biphenyl structure and preparation method thereof

Examples

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preparation example Construction

[0065] The preparation method of PPEK and PPENK used in the following is the same as that of 'Wang Mingjing. Research on a new type of polyarylether eye with phthalazinone biphenyl structure [D]. Dalian: Dalian University of Technology, 2007'; the preparation of PPBES and PPBESK used in the following The method is the same as that of 'Xiao Lihong. Synthesis and properties of multi-component copolyaryl ethers containing heterogeneous biphenyl structure [D]. Dalian: Dalian University of Technology, 2008'. The physical and chemical properties of PPEK, PPEK, PPBES, and PPBESK used below are shown in Table 1:

[0066] Table 1 Physicochemical properties of PPEK, PPENK, PPBES, PPBESK

[0067]

[0068] The structural formula of PPENK is as follows:

[0069]

Embodiment 1

[0071] The first step is to prepare the three-dimensional surface of the PPENK sheet

[0072] Sonicate the PPENK sheet by immersing it in acetone for 10 minutes, immersing it in ethanol for 10 minutes, and immersing it in ultrapure water for 10 minutes. At room temperature (22-25°C), immerse about 0.13g of PPENK slices in concentrated sulfuric acid with a concentration of 96%. After 3 minutes, quickly take out the PPENK slices and place them in a mixture of ice and water at about 4°C for 30 minutes. Washed twice with deionized water, put into blast oven to dry after washing, and obtain PPENK sheet after three-dimensional surface modification.

[0073]In the second step, a polydopamine layer is deposited on the three-dimensional surface of the polyarylether ketone (PPENK) material by dopamine self-polymerization.

[0074] Tris aqueous solution was used as a buffer solution to prepare 10 mL of a dopamine solution with a concentration of 2 mg / mL, and the pH value was adjusted to...

Embodiment 2

[0077] The biomimetic mineralization modification of polydopamine-modified PPENK sheets with a three-dimensional surface was performed on bone-like apatite for 2 days, and the rest of the steps were the same as in Example 1.

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Abstract

The invention discloses a surface modified polyarylether bone implant material containing a phthalazinone biphenyl structure and a preparation method thereof. The polyarylether bone implant material comprises polyarylether containing the phthalazinone biphenyl structure, a polydopamine layer and an osteolite-like layer, wherein the surface of the polyarrylether is of a three dimensional structurewith holes; the polydopamine layer is attached to the surface of the polyarrylether; and the osteolite-like layer is attached to the surface of the polydopamine layer. The preparation method of the surface modified polyarylether bone implant material containing the phthalazinone biphenyl structure comprises the following steps: preparing the three dimensional structure with holes on the surface ofpolyarrylether; modifying polyarrylether by polydopamine; and preparing the osteolite-like layer. The polyarylether material has relatively high biocompatibility, osteogenic activity and surface coating stability.

Description

technical field [0001] The invention belongs to the technical field of medical polymer implant materials, and relates to a surface-modified polysquare ether polymer implant material with osteogenic activity, in particular to a surface-modified phthalazinone-containing biphenyl structure A polyarylether bone implant material and a preparation method thereof. Background technique [0002] Bone repair materials are one of the biomedical materials with the greatest clinical demand. As a kind of bone repair materials, bone implant materials have always been paid attention to by people. Because of its unique properties and advantages, polymer bone implant materials account for a large proportion of bone implant materials. The internal environment is a liquid environment, and polymer bone implant materials must meet the requirements of non-toxicity, excellent biocompatibility, chemical stability, suitable physical and mechanical properties, easy processing and molding, and good co...

Claims

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Application Information

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IPC IPC(8): A61L27/32A61L27/34A61L27/18A61L27/50A61L27/54A61L27/56
CPCA61L27/18A61L27/32A61L27/34A61L27/50A61L27/54A61L27/56A61L2430/02A61L2420/08A61L2400/18A61L2420/02C08L79/02C08L71/12
Inventor 蹇锡高柳承德刘程王锦艳张守海
Owner DALIAN UNIV OF TECH
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