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Berberine used in treatment of heart failure or cardiac hypertrophy

A technology for heart failure and myocardial hypertrophy, which is applied in cardiovascular system diseases, medical preparations containing active ingredients, organic active ingredients, etc. The effect of improving heart function

Inactive Publication Date: 2019-02-22
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the pathogenesis of heart failure has not yet been elucidated, there is currently no specific treatment or drug that reverses the progression of the disease

Method used

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  • Berberine used in treatment of heart failure or cardiac hypertrophy
  • Berberine used in treatment of heart failure or cardiac hypertrophy
  • Berberine used in treatment of heart failure or cardiac hypertrophy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 1. Test method

[0041] (1) Experimental animals:

[0042] Healthy and clean male SD rats, weighing 180±20g, were purchased from Chongqing Tengxin Biotechnology Co., Ltd., experimental animal production license number: SCXK (Chongqing) 2017-0005. The experimental rats were reared in a natural day-night cycle environment, the ambient temperature was 25±2°C, and the humidity was 65%±2%.

[0043] (2) Experimental instruments and reagents:

[0044] Intelligent non-invasive blood pressure monitor (mouse instrument) (BP-2010A, Beijing Ruanlong Biotechnology Co., Ltd.);

[0045] Ultra-high resolution small animal color Doppler ultrasound real-time imaging system ( 2100 Imaging System, VisualSonics Canada);

[0046] Biological function experiment system (BL-410, Chengdu Taimeng Software Co., Ltd.);

[0047] 1 / 10,000 analytical balance (BSA-224S-CW, Sartorius, Germany);

[0048] Percent balance (YP802N, Shanghai Precision Scientific Instrument Co., Ltd.);

[0049] Berber...

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PUM

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Abstract

The invention belongs to the technical field of pharmaceutical preparations comprising an organic active ingredient with an oxygen atom as a hetero atom, in particular to berberine used in the treatment of heart failure or cardiac hypertrophy. Berberine can be used for preventing and treating pressure load-induced cardiac hypertrophy and heart failure, especially for hypertension-induced cardiac hypertrophy and heart failure, and can lower blood pressure, improve a cardiac function, prevent a cardiac remodeling process and prevent a heart from entering a heart failure stage. Berberine can be used as a drug and a health care product for preventing and treating pressure load-induced heart failure, has the dual effects of lowering blood pressure and improving the heart function, is small in side effects, and can reduce the burden of medication on patients.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations containing organic active ingredients with oxygen atoms as heteroatoms, and specifically relates to berberine used in the treatment of heart failure or myocardial hypertrophy. Background technique [0002] Heart failure (referred to as heart failure) is a complex clinical syndrome caused by abnormal changes in the structure and function of the heart caused by various heart diseases, causing ventricular contraction and ejection and / or diastolic dysfunction, which is mainly manifested as exercise tolerance. Decrease (dyspnea, fatigue) and fluid retention (pulmonary congestion, systemic circulation congestion and peripheral edema), with high disability rate and high mortality rate (“Guidelines for Rational Medication of Heart Failure”, Expert Committee on Rational Drug Use of National Health and Family Planning Commission, etc., China Journal of Medical Preface (Electronic Edition...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61P9/00A61P9/04
CPCA61K31/4375A61P9/00A61P9/04
Inventor 辛文宽王雅倩赵军利
Owner SOUTHWEST UNIVERSITY
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