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Manufacture method and application of chlordimeform electrochemiluminescence sensor

An electrochemical and insecticidal amidine technology, which is applied in chemiluminescence/bioluminescence, electrochemical variables of materials, and analysis by causing chemical reactions to occur in materials, etc. problems such as reduced stability and reproducibility, to achieve the effects of excellent electron transfer capability, reduced detection cost, and convenient operation

Active Publication Date: 2019-02-05
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the preparation process of traditional MIP-ECS, there are disadvantages such as difficult elution of template molecules, difficulty in controlling the thickness of imprinted membranes, and poor reproducibility, which limit the application of molecularly imprinted membranes in electroanalytical chemical sensors.
These problems, especially the difficult control of the thickness of the molecularly imprinted membrane, which leads to the decrease of the sensitivity of the electrochemical sensor, and the technical difficulties that the molecularly imprinted membrane is easily detached from the electrode surface during the elution process, resulting in a decrease in stability and reproducibility, limit the application of MIP_ECS. It is of great research significance and market value to find new synthesis methods for molecularly imprinted polymers, new methods for modifying molecularly imprinted membrane electrodes, and methods for combining molecularly imprinted membranes with substrate materials to solve the problems of preparation and application of MIP-ECS.

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  • Manufacture method and application of chlordimeform electrochemiluminescence sensor

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Example 1 Preparation of CoNiN-nanoarray

[0030] (1) Use dilute hydrochloric acid, absolute ethanol and deionized disposable electrode for ultrasonic cleaning to remove the oxide layer and surface impurities of the disposable electrode;

[0031] (2) Weigh 1 mmol Ni(NO 3 ) 2 and Co(NO 3 ) 2 mixture and 3 mmol urea CO(NH 2 ) 2 , put it into a 50mL beaker, add 30mL deionized water and stir until clear, then transfer to a 50mL polytetrafluoroethylene reactor;

[0032] (3) Put the disposable disposable electrode treated in step (1) into the solution in the reaction kettle in step (2), and react at a temperature of 100°C for 12 hours to prepare cobalt-nickel bimetallic layered hydrogen Oxide nanosheet array precursor electrode;

[0033] (4) Insert the cobalt-nickel double metal layered hydroxide nanosheet array precursor electrode obtained in step (3) into the phosphate buffer solution PBS containing dopamine and ammonium persulfate, and react at a temperature of 20 °...

Embodiment 2

[0035] Example 2 Preparation of CoNiN-nanoarray

[0036] (1) Use dilute hydrochloric acid, absolute ethanol and deionized disposable electrode for ultrasonic cleaning to remove the oxide layer and surface impurities of the disposable electrode;

[0037] (2) Weigh 2 mmol Ni(NO 3 ) 2 and Co(NO 3 ) 2 mixture and 6 mmol urea CO(NH 2 ) 2 , put it into a 50mL beaker, add 30mL deionized water and stir until clear, then transfer to a 50mL polytetrafluoroethylene reactor;

[0038] (3) Put the disposable disposable electrode treated in step (1) into the solution in the reaction kettle in step (2), and react at a temperature of 110°C for 11 hours to prepare cobalt-nickel bimetallic layered hydrogen Oxide nanosheet array precursor electrode;

[0039] (4) Insert the cobalt-nickel bimetal layered hydroxide nanosheet array precursor electrode obtained in step (3) into the phosphate buffer solution PBS containing dopamine and ammonium persulfate, and react at 30 °C for 5 hours , taken...

Embodiment 3

[0041] Example 3 Preparation of CoNiN-nanoarray

[0042] (1) Use dilute hydrochloric acid, absolute ethanol and deionized disposable electrode for ultrasonic cleaning to remove the oxide layer and surface impurities of the disposable electrode;

[0043] (2) Weigh 3 mmol Ni(NO 3 ) 2 and Co(NO 3 ) 2 mixture and 9 mmol urea CO(NH 2 ) 2 , put it into a 50mL beaker, add 30mL deionized water and stir until clear, then transfer to a 50mL polytetrafluoroethylene reactor;

[0044] (3) Put the disposable disposable electrode treated in step (1) into the solution in the reaction kettle in step (2), and react at a temperature of 130°C for 9 hours to prepare cobalt-nickel bimetallic layered hydrogen Oxide nanosheet array precursor electrode;

[0045] (4) Insert the cobalt-nickel double metal nitride nanosheet array precursor electrode obtained in step (3) into the phosphate buffer solution PBS containing dopamine and ammonium persulfate, react at 40 °C for 6 hours, take it out and u...

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Abstract

The invention discloses a manufacture method of a chlordimeform electrochemiluminescence sensor, and belongs to the technical field of novel nanometer functional materials and biosensing analysis. Themethod comprises the following steps that: firstly, preparing a cobalt-nickel bimetallic nitride nanosheet array on a disposable electrode, utilizing the large specific surface area of the cobalt-nickel bimetallic nitride nanosheet array, and high adsorption activity for amino as well as the amino functional group of polydopamine, adopting an in-situ growth method to directly prepare a polydopamine film and a molecularly imprinted polymer which is in situ coated with luminol and takes chlordimeform as a template molecule in sequence on the cobalt-nickel bimetallic nitride nanosheet array, after the template molecule is eluted, changing the position of the original template molecule into a hole, i.e., the molecularly imprinted polymer of which the template molecule is eluted, and therefore, finishing manufacturing the chlordimeform electrochemiluminescence sensor.

Description

technical field [0001] The invention relates to a preparation method and application of an electrochemiluminescence sensor. It belongs to the field of new nano functional material and biosensing analysis technology. Background technique [0002] Dimeform, also known as ampicillin, is a β-lactam antibiotic and a semi-synthetic broad-spectrum penicillin that can treat a variety of bacterial infections. Indications include respiratory tract infection, urinary tract infection, meningitis, salmonella infection, and endocarditis. Because of its convenient use and low cost, it is mostly used to treat infectious diseases caused by sensitive bacteria in chickens, such as Escherichia coli, Salmonella, Pasteurella, Staphylococcus and Streptococcus infections. On October 27, 2017, in the list of carcinogens released by the International Agency for Research on Cancer of the World Health Organization, ampicillin was included in the list of category 3 carcinogens. Therefore, the develop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/26G01N27/30G01N27/327G01N21/76
CPCG01N21/76G01N27/26G01N27/30G01N27/3278
Inventor 张勇程荣琦杜斌
Owner UNIV OF JINAN
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