Anoxia-resistant composition and application thereof

A composition and hypoxia-resistant technology, applied in the field of medicine, to achieve good curative effect, improve hypoxia tolerance, and improve the effect of headache

Pending Publication Date: 2019-02-05
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported in the prior art that hydroxytyrosol has a variety of biological activities, such as anti-oxidation, anti-cancer, vision protection, enhancement of cartilage repair, blood lipid reduction, treatment of prostate diseases, etc., but so far no hydroxytyrosol has the ability to Reports of biological activity in the prevention or treatment of hypoxic symptoms (such as altitude sickness)

Method used

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  • Anoxia-resistant composition and application thereof
  • Anoxia-resistant composition and application thereof
  • Anoxia-resistant composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A tablet made from a composition for preventing and / or treating hypoxic symptoms, the raw material components are as follows:

[0030] Hydroxytyrosol 5g, salidroside 250g, microcrystalline cellulose 150g, 8% starch slurry 20g, sodium bisulfite 0.1g.

[0031]Mix the above raw materials uniformly, pulverize them, pass through a 14-mesh sieve, granulate, dry in vacuum at 45°C for 2 hours, add 4g of talc powder, mix uniformly, granulate, and press into tablets.

Embodiment 2

[0033] A tablet made from a composition for preventing and / or treating hypoxic symptoms, the raw material components are as follows:

[0034] Hydroxytyrosol 10g, salidroside 200g, microcrystalline cellulose 150g, 8% starch slurry 20g, sodium bisulfite 0.1g.

[0035] Mix the above raw materials uniformly, pulverize them, pass through a 14-mesh sieve, granulate, dry in vacuum at 45°C for 2 hours, add 4g of talc powder, mix uniformly, granulate, and press into tablets.

Embodiment 3

[0037] A capsule made from a composition for preventing and / or treating hypoxic symptoms, the raw material components are as follows:

[0038] Hydroxytyrosol 40g, salidroside 100g, starch 70g, microcrystalline cellulose 80g, 8% starch slurry 20g, sodium bisulfite 0.1g.

[0039] The above raw materials were mixed uniformly, pulverized, passed through a 14-mesh sieve, granulated, vacuum-dried at 45°C for 2 hours, then 4g of talcum powder was added, mixed uniformly, granulated, and packed into capsules.

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PUM

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Abstract

The invention provides an anoxia-resistant composition. The anoxia-resistant composition is prepared from salidroside and hydroxytyrosol or derivatives thereof, wherein the mass ratio of the hydroxytyrosol or derivatives thereof to the salidroside is (1 to 100) to (20 to 1). The invention further provides application of the hydroxytyrosol or derivatives in preparation of drugs or functional food for preventing and/or treating anoxic symptoms. The remarkable anti-anoxia activity is achieved through combination of the hydroxytyrosol or derivatives thereof with the salidroside, and the activity is better than that of the single component of the salidroside or hydroxytyrosol; through the synergistic effect of the two, a small dose can achieve better curative effect, and the burden of drugs onpatients can be relieved; the anoxia-resistant composition can be used for preventing and/or treating diseases caused by various anoxic conditions, such as altitude stress, relieving the anoxic symptoms such as headache, dizziness, nausea and vomiting, and peripheral edema, and improving the hypoxia endurance of a body.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a hypoxia-resistant composition and its application. Background technique [0002] Altitude sickness is common in people who have first arrived at altitude, and these individuals often have not acquired a certain degree of altitude acclimatization. The symptoms of altitude sickness are self-limiting. If you can rest in time after the symptoms appear, they will usually disappear on their own after 2 to 3 days. However, if you continue to engage in aerobic physical exercise after altitude sickness, or climb to a high altitude area where oxygen is scarcer, the symptoms of altitude sickness will aggravate and even progress to high altitude cerebral edema or high altitude pulmonary edema, which will be life-threatening. [0003] The main factors affecting the occurrence of altitude sickness are altitude, climbing speed and individual susceptibility. After the body enters the plat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7032A61K31/05A61K31/222A61P39/00A23L33/10A23L33/105
CPCA23L33/10A23L33/105A23V2002/00A61K31/05A61K31/222A61K31/7032A61P39/00A61K2300/00A23V2200/30A23V2250/2132A23V2250/60
Inventor 凌沛学吴季栩邵华荣郭新艳边玲刘飞张金华程艳玲张建强张岱州李帅广
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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