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Method for separating and preparing salidroside

A technology for salidroside and ethanol, which is applied in the field of preparation for separation of salidroside, can solve the problems of inability to large-scale production, low product purity, poor reproducibility, etc., and achieves high sample purity suitable for industrialized large-scale production. High, short cycle effect

Active Publication Date: 2008-10-22
浙江华谱新创科技有限公司
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AI Technical Summary

Benefits of technology

This patented method improves both accuracy and efficiency during manufacturing of Salidrosides products compared to existing techniques like Solvax® or Silix Technologies' HPLC columns. It also reduces environmental concerns associated with these chemical reactions due to its low content of volatile compounds. Additionally, this new technique allows for better control over quality attributes related to the final drug substance itself while maintaining good separability properties. Overall, this innovative technical effect makes the current methods expensive but effective at producing highly pure drugs.

Problems solved by technology

This patented technical problem addressed by this patents relates to extracting and separating out crude drugs from roots called rulerasides which contain various compounds like salisoxytolones, pigments, carboxysporins, flavonoids, etc., along with other substances found naturally occurring during plant growth processes for medicinal purposes including use against diseases related conditions. These natural products can be extracted without causing harmful side reactions when administered into humans. However, current techniques require expensive equipment and involve complicated steps making it difficult to manufacture them commercially.

Method used

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  • Method for separating and preparing salidroside
  • Method for separating and preparing salidroside

Examples

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Embodiment 1

[0022] Crush the original medicinal material of Rhodiola rosea, weigh 1 kg quantitatively, put it in a 50-liter extraction tank, add 10 liters of water to decoct for 2 hours, filter, and save the filtrate for later use, add 10 liters of water to the filter residue and decoct for 2 hours, filter, and the filtrate Combined with the first time, the filter residue was discarded. The extract was concentrated by rotary evaporation to obtain 240 ml of extract with a relative density of 1.12. Add 412 milliliters of 95% ethanol to the extract, stir well, leave it in a refrigerator at 0°C for 24 hours, filter, discard the filter residue, and concentrate the filtrate to 160 milliliters, relative density 1.05, add 854 milliliters of 95% ethanol to the concentrated solution, fully Stir, refrigerate and stand at 0°C for 24 hours, filter, discard the filter residue, concentrate the filtrate until it has no alcohol smell, and centrifuge the concentrated solution in a high-speed centrifuge (20...

Embodiment 2

[0030] Crush the original medicinal material of Rhodiola rosea, weigh 0.5 kg quantitatively, put it in a 20-liter extraction tank, add 6 liters of water to decoct for 1 hour, filter, and save the filtrate for later use, add 5 liters of water to the filter residue and decoct for 3 hours, filter, and the filtrate Combined with the first time, the filter residue was discarded. The extract was concentrated by rotary evaporation to obtain 140 ml of extract with a relative density of 1.10. Add 240 milliliters of 95% ethanol to the extract, fully stir, refrigerate and stand for 24 hours at 0°C, filter, discard the filter residue, and concentrate the filtrate to 40 milliliters, relative density 1.07, add 428 milliliters of 95% ethanol to the concentrated solution, fully Stir, refrigerate and stand at 0°C for 24 hours, filter, discard the filter residue, concentrate the filtrate until it has no alcohol smell, and centrifuge the concentrated solution in a high-speed centrifuge (20,000 r...

Embodiment 3

[0034] Crush the original medicinal material of Rhodiola rosea, weigh 5 kg quantitatively, put it in a 250-liter extraction tank, add 60 liters of water to decoct for 2 hours, filter, and save the filtrate for later use, add 60 liters of water to the filter residue and decoct for 2 hours, filter, and the filtrate Combined with the first time, the filter residue was discarded. The extract was concentrated by rotary evaporation to obtain 1.2 liters of extract with a relative density of 1.13. Add 2.1 liters of 95% ethanol to the extract, stir fully, and refrigerate at 0°C for 24 hours, filter, discard the filter residue, and concentrate the filtrate to 0.7 liters, relative density 1.08, add 3.8 liters of 95% ethanol to the concentrated solution, fully Stir, refrigerate and stand at 0°C for 24 hours, filter, discard the filter residue, concentrate the filtrate until it has no alcohol smell, and centrifuge the concentrated solution in a high-speed centrifuge (20,000 rpm) to obtain ...

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Abstract

The invention relates to the separation of natural medicines, in particular to a separation and preparation method of the salidroside; wherein, extracting solution is obtained by decocting the ground rhodiola with ten times of water, and then the extract (the relative density is from 1.10 to 1.15) is obtained after the extracting solution is concentrated, and then the ethanol is added for twice of alcohol precipitation, and then the eluate is collected by separating the solution with a 6000a molecular weight membrane separator and an efficient industrial chromatographic column and eluting the methanol water with gradients and then the salidroside is obtained by collecting, concentrating, freezing and drying the eluate. The method is high in product purity, large in preparation amount and stable and reliable in process and especially suitable for separating and preparing a great amount of highly purified salidroside compounds from the traditional Chinese medicine rhodiola.

Description

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Claims

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Application Information

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Owner 浙江华谱新创科技有限公司
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