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New uses of Acanthopanax senticosus-Angelica sinensis-Milkvetch Root traditional Chinese medicine composition in assisted blood glucose lowering

The technology of the extract and composition of Acanthopanax senticosus and Angelica Astragalus is applied in the new application field of the composition of Acanthopanax senticosus and Angelica Astragali to assist in lowering blood sugar. The effect of remarkable hypoglycemic effect and remarkable effect

Active Publication Date: 2019-01-29
TONGYAO PHARMA GROUP CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the traditional Chinese medicine composition disclosed in the above-mentioned patent can treat diabetes, its prescription has many medicinal flavors and complicated ingredients, so it is difficult to control the quality of the product

Method used

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  • New uses of Acanthopanax senticosus-Angelica sinensis-Milkvetch Root traditional Chinese medicine composition in assisted blood glucose lowering
  • New uses of Acanthopanax senticosus-Angelica sinensis-Milkvetch Root traditional Chinese medicine composition in assisted blood glucose lowering
  • New uses of Acanthopanax senticosus-Angelica sinensis-Milkvetch Root traditional Chinese medicine composition in assisted blood glucose lowering

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Acanthopanax 200g, add water and decoct four times, 1 hour each time, combine the decoction, filter, concentrate the filtrate to a thick paste, add three times the amount of ethanol, mix well, place, filter, recover ethanol, add gelatin solution to If no precipitation occurs, add five times the amount of ethanol, let it sit for 2 hours and filter, recover ethanol, and concentrate to a thick paste.

[0033] Add 100g of Angelica sinensis and 200g of Astragalus membranaceus, add water and decoct three times, 1 hour each time, combine the decoction, filter, concentrate the filtrate to a thick paste, add three times the amount of ethanol, mix well, place, filter, recover ethanol, and repeat twice Alcohol treatment, concentrated to thick paste;

[0034] Take 500g of honey and heat to melt, add an appropriate amount of water to dissolve the above thick paste, filter, add the filtrate to 500g of honey, stir well, add preservatives, appropriate amount of spices, 6g of sodium cit...

Embodiment 2

[0036] Acanthopanax 200g, add water and decoct four times, 1 hour each time, combine the decoction, filter, concentrate the filtrate to a thick paste, add three times the amount of ethanol, mix well, place, filter, recover ethanol, add gelatin solution to If no precipitation occurs, add five times the amount of ethanol, let stand for 2 hours and filter, recover ethanol, and obtain the filtrate.

[0037] Add 100g of Angelica sinensis and 200g of Astragalus membranaceus, add water and decoct three times, 1 hour each time, combine the decoction, filter, concentrate the filtrate to a thick paste, add three times the amount of ethanol, mix well, place, filter, recover ethanol, and repeat twice Alcohol treatment, the filtrate was concentrated to a thick paste.

[0038] On the basis of drying the thick paste under reduced pressure, add appropriate auxiliary materials (or starch) to make 1000g, and mix to make 0.5g / capsules.

Embodiment 3

[0040]Take 100g of Angelica sinensis and add 8 times the amount of water, soak for 1 hour, extract the volatile oil by steam distillation for 6 hours, collect the volatile oil, dissolve it with the same amount of ethanol, and set aside; weigh β-cyclodextrin with 6 times the amount of volatile oil to make it at 45~55℃ Add the volatile oil while stirring, and keep stirring at 30-50°C for 5 hours, refrigerate overnight, filter, and dry the clathrate to obtain the clathrate of volatile oil, which is set aside. The distilled aqueous solution is collected in another device and set aside; the dregs, Acanthopanax 200g, Astragalus 200g, add water and decoct three times, 8 times the amount for the first time, 6 times the amount for the second time, 6 times the amount for the third time, 1 hours, filter, combine the filtrate and the above aqueous solution, concentrate under reduced pressure to a clear paste with a relative density of 1.10-1.20 (80°C), take appropriate amount of β-cyclodex...

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Abstract

The present invention provides applications of a traditional Chinese medicine composition in preparation of blood glucose lowering drugs, wherein the traditional Chinese medicine composition comprises, by mass, 1-3 parts of Acanthopanax senticosus, 0.5-1.5 parts of Angelica sinensis, and 1-3 parts of Milkvetch Root. The present invention further provides applications of a composition in preparation of blood glucose lowering drugs, wherein the composition comprises, by mass, 1-3 parts of an Acanthopanax senticosus extract, 0.5-1.5 parts of an Angelica sinensis extract, and 1-3 parts of a Milkvetch Root extract. According to the present invention, Acanthopanax senticosus, Angelica sinensis and Milkvetch Root are used as the active components and are used for preparing blood glucose loweringdrugs; and the experimental results show that the traditional Chinese medicine composition can significantly reduce the fasting blood glucose of mice, reduce the glycated hemoglobin of diabetic mice,and increase the serum insulin secretion, and has obvious effect superior to the traditional Chinese medicine composition containing complex components, wherein the effect difference between the traditional Chinese medicine composition of the present invention and the traditional Chinese medicine composition containing complex components is significant (P < 0.05).

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a novel use of a composition of Acanthopanax plus Angelica and Astragalus for assisting in lowering blood sugar. Background technique [0002] In recent years, with the development of social economy and the improvement of residents' living standards in various countries in the world, the incidence and prevalence of diabetes have increased year by year, becoming a major social problem that threatens people's health, causing governments, health departments and medical workers in various countries to attention and attention. [0003] At present, the treatment of diabetes is mainly based on western medicine, including α-glucosidase inhibitors such as glucopine, and drugs that promote glucose absorption such as metformin. , gastrointestinal reactions and other side effects, with the prolongation of treatment time, the hypoglycemic effect tends to decrease, and...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61P3/10
CPCA61K36/232A61K36/254A61K36/481A61P3/10A61K2300/00
Inventor 许艳茹石菊徐建展月宫海全
Owner TONGYAO PHARMA GROUP CORP
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