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Passiflora edulis peel polysaccharide carboxymethylation modification product with improved antioxidant activity and preparation method of product

A technology of carboxymethylation and carboxymethylation of passionflower, applied in the direction of organic active ingredients, medical preparations containing active ingredients, anti-toxic agents, etc.

Active Publication Date: 2019-01-18
GUILIN UNIVERSITY OF TECHNOLOGY
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Problems solved by technology

There are no domestic and foreign literature reports on the preparation and antioxidant activity of carboxymethylated derivatives of passion fruit peel polysaccharides

Method used

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  • Passiflora edulis peel polysaccharide carboxymethylation modification product with improved antioxidant activity and preparation method of product
  • Passiflora edulis peel polysaccharide carboxymethylation modification product with improved antioxidant activity and preparation method of product
  • Passiflora edulis peel polysaccharide carboxymethylation modification product with improved antioxidant activity and preparation method of product

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Embodiment Construction

[0016] The technical solution of the present invention will be further described below through examples.

[0017] 1. Preparation of passion fruit peel polysaccharide

[0018] Passion fruit peel was washed, dried at 50°C, crushed, condensed and refluxed with 80% ethanol at 85°C for 3 times, 2 hours each time, and the residue was separated and dried. Weigh 5g of the above residue, add distilled water according to a certain ratio of material to liquid, extract with microwave, filter with suction, centrifuge the filtrate to get the supernatant concentrated, add 4 times the volume of absolute ethanol to precipitate, let stand at 4°C for 48h, 4000r / min, centrifuge for 15min, The supernatant was freeze-dried to obtain the crude polysaccharide from passion fruit peel (WPEP).

[0019] 2. Carboxymethylation modification of passion fruit peel polysaccharide

[0020] Weigh the passion fruit peel polysaccharide, add NaOH and isopropanol solution, ice bath, stir to make a uniform suspensi...

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Abstract

The invention relates to a carboxymethylation modification method for enhancing antioxidant activity of passiflora edulis peel polysaccharide. Carboxymethylation modification is performed with a sodium hydroxide-chloroacetic acid method, arboxymethylation substitution degree is used as an index, three factors including NaOH concentration, reaction time and reaction temperature are studied with single factor, and carboxymethylated passiflora edulis peel polysaccharide with different substitution degrees is obtained. The invention also relates to an application of the carboxymethylated passiflora edulis peel polysaccharide in pharmacy, in particular in preparation of antioxidant drugs, including DPPH free radical and hydroxyl free radical removing drugs, superoxide anion drugs and F3<3+> reduction capacity drugs. The artificially synthesized carboxymethylated passiflora edulis peel polysaccharide with different substitution degrees is applied to in vitro antioxidant activity tests, and areference basis is provided for application of the carboxymethylated passiflora edulis peel polysaccharide in medical field.

Description

technical field [0001] The invention relates to a passion fruit peel polysaccharide, in particular to a passion fruit peel polysaccharide carboxymethylated modification product with improved antioxidant activity and a preparation method thereof. Background technique [0002] Passionflower (Passiflora edulis Sims), also known as passion fruit and egg fruit, belongs to the fruit of Passiflora genus in Passiflora family. It is a typical high-quality fruit with the same source of medicine and food, and has high medicinal value. and food value. Traditional Chinese medicine studies have shown that passionflower has various effects such as anti-inflammatory, sedative, anti-anxiety, anti-addiction, and treatment of insomnia. [0003] Polysaccharides are natural products with a wide range of sources, and have the advantages of less toxic and side effects, no residue, and no drug resistance, so they have attracted the attention of researchers. Modern research has found that the biol...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715A61P39/06
CPCA61K31/715A61P39/06C08B37/00
Inventor 李霞胡楠郑里华崔萌佳
Owner GUILIN UNIVERSITY OF TECHNOLOGY
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