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Pharmacodynamic application of schizocapsa plantaginea saponin in preparing drug for treating hepatic fibrosis

A technology of liver fibrosis and diosgenin, applied in the field of application of steroidal saponins as raw materials in the preparation of anti-hepatic fibrosis drugs, can solve the problem of less pharmacodynamic research

Inactive Publication Date: 2019-01-11
GUANGXI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the publicly reported studies on diosmin are mainly focused on the separation and identification of its chemical constituents, and there are few studies on its pharmacodynamics, and there is no report on the use of diosin to resist liver fibrosis.

Method used

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  • Pharmacodynamic application of schizocapsa plantaginea saponin in preparing drug for treating hepatic fibrosis
  • Pharmacodynamic application of schizocapsa plantaginea saponin in preparing drug for treating hepatic fibrosis
  • Pharmacodynamic application of schizocapsa plantaginea saponin in preparing drug for treating hepatic fibrosis

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Experimental program
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Embodiment Construction

[0034] 1. Preparation of Dioscorein

[0035] Cracked potato tuber powder is extracted with 80% ethanol under normal pressure reflux, and the ethanol extract content is 85.31%, followed by petroleum ether (60-90°C), ethyl acetate, water-saturated n-butanol to extract the ethanol extract, and n-butanol to extract Parts were enriched with saponins by D101 macroporous adsorption resin, and 50%-95% ethanol gradient elution was obtained to obtain total saponins of split fruit potato (SFSP); 0.05, 6:1:0.05, 4:1:0.05) gradient elution, collected and combined eluents, purified several times, and then eluted with chloroform-methanol (1:1) Sephadex LH-20 column, after multiple purifications The split fruit dioscoside compounds SPHS Ⅰ and SPHS Ⅱ were obtained.

[0036] Results: In addition to the total saponins of split fruit diosmin (SFSP), two monomers of split fruit diosin compounds were isolated, and their structures were identified as follows:

[0037] ① Taccaoside Ⅰ (25S)-spirost-...

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Abstract

The invention discloses a pharmacodynamic application of schizocapsa plantaginea saponin in preparing a drug for treating hepatic fibrosis. The invention researches hepatic fibrosis resistance of schizocapsa plantaginea saponin for the first time. In vitro and in vivo experiments verify that the schizocapsa plantaginea saponin has a relatively good action of inhibiting proliferation of hepatic stellate cells and activity of resisting hepatic fibrosis. The schizocapsa plantaginea saponin can be used as an active component of the hepatic fibrosis resistant drug, and has a wide application. The research finds that the schizocapsa plantaginea saponin shows good hepatic fibrosis resistant action from in vivo and in vitro experiments and is a novel drug with a potential value for treating chemical hepatic fibrosis.

Description

technical field [0001] The invention belongs to the field of pharmacy, and the invention relates to the application of the traditional Chinese medicine dioscin extract, in particular the application of the total diosin extract and steroidal saponins as raw materials in the preparation of anti-hepatic fibrosis medicine. Background technique [0002] Hepatic fibrosis (hepatic fibrosis) is a compensatory response in the tissue repair process secondary to various forms of chronic liver injury. It is also a necessary pathological process for all chronic liver diseases to develop into cirrhosis. There are many causes of liver fibrosis, including viral Sexuality, autoimmunity, drugs or poisons, cholestasis, and metabolic diseases, etc., the terminal stage will develop into cirrhosis, portal hypertension, liver failure, and hepatocellular carcinoma. Therefore, blocking the occurrence and development of liver fibrosis is of great significance to the prevention and treatment of liver ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/702A61P1/16
CPCA61K31/702A61P1/16
Inventor 梁钢廖智红甘日植黄修影吕美娴
Owner GUANGXI MEDICAL UNIVERSITY
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