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Medicine composition and application thereof

A composition and drug technology, applied in the field of medicine, can solve the problems of small toxicity, no anti-tumor activity, etc., and achieve the effects of low preparation cost, large distribution of wild resources, and obvious effects

Inactive Publication Date: 2018-12-25
QINGHAI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The plant is slightly poisonous and has the functions of expelling rheumatism, detoxification, and killing insects. Gansu folks use its roots and rhizomes to treat pharyngitis, but it has not been found to have anti-tumor activity

Method used

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  • Medicine composition and application thereof
  • Medicine composition and application thereof
  • Medicine composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Grind 10kg of dried Artemisia annua; the powder is reflux extracted with 95% ethanol for 3 times, each time for 2 hours, and the extract is recovered; the extract is concentrated under reduced pressure into an extract, diluted with water, and adjusted to pH 2. Extract with petroleum ether and ethyl acetate in sequence, adjust the pH of the aqueous layer to 11 with NaOH solution, and extract with chloroform to obtain 190 g of total alkaloid extract of Artemisia annua, with a yield of 1.90%.

[0028] Take 5g of the total alkaloid extract of Artemisia annua prepared above, add 85g of starch and 5g of acrylic resin, mix evenly with equal volume increment method, use 80% ethanol to make granules, dry, granulate, mix evenly, add talc Powder 3.2g, magnesium stearate 1.8g, tableting promptly obtains the pharmaceutical composition tablet containing the total alkaloid extract of Artemisia annua.

Embodiment 2

[0030] Grind 10kg of dried Artemisia annua; the powder is extracted twice with 95% ethanol under reflux, each time for 2 hours, and the extract is recovered; the extract is concentrated under reduced pressure to form an extract, diluted with water, and adjusted to pH 3. Extract with petroleum ether and ethyl acetate in sequence, adjust the pH of the aqueous layer to 11 with NaOH solution, and extract with chloroform to obtain 179 g of total alkaloid extract of Artemisia annua, with a yield of 1.79%.

[0031] Take 15g of the total alkaloid extract of Artemisia annua prepared above, add 55g of dextrin, 15g of lactose, 5g of microcrystalline cellulose, 8g of stearic acid, and 2g of hypromellose to make granules, dry, pack into capsules, and obtain The pharmaceutical composition capsule containing the total alkaloid extract of Artemisia annua.

Embodiment 3

[0033] Grind 10kg of dried Artemisia annua; the powder is reflux extracted with 95% ethanol for 3 times, each time for 2 hours, and the extract is recovered; the extract is concentrated under reduced pressure to form an extract, diluted with water, and adjusted to 2. Extract with petroleum ether and ethyl acetate in sequence, adjust the pH of the aqueous layer to 11 with NaOH solution, and extract with chloroform to obtain 190 g of total alkaloid extract of Artemisia annua, with a yield of 1.90%.

[0034] Take 10 g of the total alkaloid extract of Artemisia annua prepared above, add 35 g of croscarmellose sodium, 25 g of povidone, 25 g of poloxamer, and 5 g of ethyl cellulose, and mix evenly by the method of equal increments, A proper amount of ethanol is used to make granules, dried, sized and mixed to obtain the pharmaceutical composition granules containing the total alkaloid extract of Artemisia annua.

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Abstract

The invention discloses a medicine composition comprising incarvillea sinensis var. przewalskii total alkaloid extracts and an application of the medicine composition to tumor resistance. The total alkaloid extracts are extracted from incarvillea sinensis var. przewalskii and assisted by pharmaceutical materials to prepare the medicine composition. The incarvillea sinensis var. przewalskii servingas a medicine source is large in wild resource distribution quantity and easy to plant, and incarvillea sinensis var. przewalskii total alkaloid extraction process is simple, so that preparation costis low. The medicine composition is fewer in side effects, good in compatibility of anti-tumor activity and obvious in effects of resisting tumor diseases such as breast cancer, esophagus cancer, liver cancer, leukemia, gastric cancer, prostatic cancer and melanoma.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular to a pharmaceutical composition containing the total alkaloid extract of Artemisia annua and its application in anti-cancer such as breast cancer, esophageal cancer, liver cancer, leukemia, gastric cancer, prostate cancer, melanoma, etc. . Background technique [0002] Artemisia annua ( Incarvillea sinensis var. przewalskii ) for Bignoniaceae ( Bignoniaceae ) Artemisia spp. ( Incarvillea Juss ) plants, born in alpine grass slopes or mixed forests at an altitude of 2000-3350 meters, mainly distributed in Gansu, Shaanxi, Qinghai, and northwest Sichuan in China. The plant is slightly poisonous and has the functions of expelling rheumatism, detoxification, and killing insects. Gansu folks use its roots and rhizomes to treat pharyngitis, but it has not been found to have anti-tumor activity. Half of the existing anti-tumor drugs will be accompanied by side effects such as ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/20A61K9/48A61K9/16A61P35/00A61P35/02
CPCA61K9/1652A61K9/2013A61K36/185A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61P35/00A61P35/02
Inventor 张寿德
Owner QINGHAI UNIVERSITY
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