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Small molecule hydrogel-nanoparticle compound drug carrier and application thereof in skin/mucosa drug delivery system

A technology of small molecule water and nanoparticles, applied in the direction of non-active ingredients of polymer compounds, medical preparations of non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of frequent drug administration, short residence time of preparations, etc. problem, to achieve the effect of improving permeability

Active Publication Date: 2018-12-25
NANJING UNIV OF TECH
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  • Application Information

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Problems solved by technology

[0005] However, the method of using lipid nanoparticles (liposomes), metal nanoparticles, polymer nanoparticles and other drug preparation carriers to improve drug permeability generally has a short residence time at the skin / mucosal administration site and requires frequent administration. The problem

Method used

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  • Small molecule hydrogel-nanoparticle compound drug carrier and application thereof in skin/mucosa drug delivery system
  • Small molecule hydrogel-nanoparticle compound drug carrier and application thereof in skin/mucosa drug delivery system
  • Small molecule hydrogel-nanoparticle compound drug carrier and application thereof in skin/mucosa drug delivery system

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Embodiment 1

[0030] Preparation of the blank transfer body: the transfer body was prepared by the film dispersion method, and the phospholipid (SPC), sodium deoxycholate and surface active ingredient (edge ​​activator, EA) were dissolved in the organic mixture of chloroform:methanol=2:1 according to the ratio in Table 1. In the solvent, the organic solvent was removed by vacuum rotary evaporation at a temperature of 40°C. The lipid component formed a lipid film on the bottle wall, and then placed in a vacuum drying kettle overnight to remove the residual organic solvent. Add ddH 2 Hydrate with O for 10 minutes, use a probe-type cell sonicator to sonicate in an ice bath for 5 minutes to disperse the lipid suspension, and pass the sonicated liposome suspension through a 0.22 μm cellulose ester membrane to obtain transfersomes (Ts) with uniform particle size . At the same time, conventional liposomes (Ls) were prepared as a control.

[0031] Preparation of drug-loaded transfer body: The pre...

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Abstract

The invention discloses a small molecule hydrogel-nanoparticle compound drug carrier and application thereof in skin / mucosa drug delivery system. The small molecule hydrogel-nanoparticle compound drugcarrier comprises drug-carrying nanoparticles and small molecule hydrogel, wherein the drug-carrying nanoparticles are dispersed in the small molecule hydrogel, and the surfaces of the nanoparticlesare modified with cell penetrating peptides. The small molecule hydrogel-nanoparticle compound drug carrier is used for skin / mucosa drug delivery, the skin / mucosa and lesion part penetrating performance of drugs can be evidently increased by modifying the surfaces of the nanoparticles with the cell penetrating peptides, and the problem that solution-dosage-form drug delivery is prone to drug lossis solved by the small molecule hydrogel.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a small molecule hydrogel-nanoparticle composite drug carrier and its application in a skin / mucosal drug delivery system. Background technique [0002] Skin / mucosal administration refers to the use of human skin or mucous membranes of various cavities (such as oral cavity, nasal cavity, lungs, etc.) as the site of administration. This type of administration can avoid the damage of the gastrointestinal tract to the drug and avoid the irritation of the drug to the gastrointestinal tract. Compared with intravenous administration, the drug is administered directly on the skin / mucosa of the lesion, allowing the drug to reach the lesion quickly The site can significantly increase the drug concentration at the lesion site and reduce the distribution of non-target tissues. It is thus a simple, fast and patient-friendly route of administration. However, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K9/127A61K9/00A61K47/24A61K47/28A61K47/42A61K47/26A61K47/18A61K31/337A61K31/428A61P35/00
CPCA61K47/183A61K47/24A61K47/26A61K47/28A61K47/42A61P35/00A61K9/0014A61K9/06A61K9/127A61K31/337A61K31/428
Inventor 姜天玥何冰芳马聿迪王彤
Owner NANJING UNIV OF TECH
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