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Microfluidic paper chip with controllable fluid transportation and its preparation method and use method

A microfluidic paper chip and fluid technology, applied in fluid controllers, chemical instruments and methods, laboratory containers, etc., can solve the problems of a large number of reactant processing procedures, flexible control of difficult fluids, etc., to speed up transportation , Easy to use, the effect of slowing down the speed of transportation

Active Publication Date: 2021-10-08
GUANGXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods are difficult to achieve flexible control of the fluid, and may require a large number of reactants or additional processing procedures

Method used

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  • Microfluidic paper chip with controllable fluid transportation and its preparation method and use method
  • Microfluidic paper chip with controllable fluid transportation and its preparation method and use method
  • Microfluidic paper chip with controllable fluid transportation and its preparation method and use method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Preparation of microfluidic paper chip with controllable fluid transport

[0030] Such as figure 2 As shown, the preparation method of the above-mentioned microfluidic paper chip, the specific steps are as follows:

[0031] S1. Hydrophobic polymers containing styrene and benzophenone structural units and hydrophilic polymers containing N,N-dimethylacrylamide, spiropyran and benzophenone structural units were synthesized by free radical polymerization ,Specific steps are as follows:

[0032] (1) Synthesize a hydrophobic macromolecule containing styrene and benzophenone structural units by free radical polymerization, and the specific steps are:

[0033] ①Synthesis of benzophenone monomer. Dissolve 25.0g of 4-hydroxybenzophenone, 13.9g of methacryloyl chloride and 13.6g of triethylamine in 300mL of dichloromethane, react at room temperature for 24h, filter, and wash the organic phase with 200mL hydrochloric acid solution (0.1M), 200mL Distilled water, 200m...

Embodiment 2

[0042] Example 2: Preparation of microfluidic paper chip with controllable fluid transport

[0043] Different from embodiment 1 is step S2 and step S3, specifically as follows:

[0044] S2. Prepare the hydrophobic polymer containing styrene and benzophenone structural units synthesized in step S1 into a 50 mg / mL tetrahydrofuran solution, soak the filter paper in the solution, take it out and dry it, and put it into a UV curing box for ultraviolet light Curing (ultraviolet wavelength is 365nm, required energy is 10J / cm 2 ), and use a light shield to cover the middle part of the filter paper during the UV curing process, and then use a Soxhlet extractor to wash the hydrophobic polymer in the non-irradiated part, so as to construct the barrier area 2 and the hydrophilic channel 4 on the filter paper.

[0045] S3. The hydrophilic polymer containing N,N-dimethylacrylamide, spiropyran and benzophenone structural units synthesized in step S1 is formulated into 30mg / mL acetone soluti...

Embodiment 3

[0046] Example 3: Preparation of microfluidic paper chip with controllable fluid transport

[0047] Different from Embodiment 1 and 2 are step S2 and step S3, specifically as follows:

[0048] S2. Prepare the hydrophobic polymer containing styrene and benzophenone structural units synthesized in step S1 into a 100 mg / mL tetrahydrofuran solution, soak the filter paper in the solution, take it out and dry it, and put it into a UV curing box for ultraviolet light Curing (ultraviolet wavelength is 365nm, required energy is 20J / cm 2 ), and use a light shield to cover the middle part of the filter paper during the UV curing process, and then use a Soxhlet extractor to wash the hydrophobic polymer in the non-irradiated part, so as to construct the barrier area 2 and the hydrophilic channel 4 on the filter paper.

[0049] S3. The hydrophilic polymer containing N,N-dimethylacrylamide, spiropyran and benzophenone structural units synthesized in step S1 is prepared into a 50 mg / mL chlor...

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Abstract

The invention discloses a microfluidic paper chip with controllable fluid transport and its preparation method and application method. The microfluidic paper chip includes a sample area (unmodified filter paper area), a barrier area (containing styrene and diphenyl Hydrophobic polymer modified filter paper area with ketone structural unit) and control area (hydrophilic polymer modified filter paper area containing N,N-dimethylacrylamide, spiropyran and benzophenone structural unit). In the present invention, filter paper is used as a matrix, and hydrophobic polymers and hydrophilic polymers are respectively fixed on the outside of the flow channel and in the flow channel on the filter paper in the form of chemical covalent bonds through the methods of impregnation, ultraviolet light curing and solvent cleaning. Construct the barrier area, control area and sample area in sequence. The preparation method of the present invention is simple, and the prepared microfluidic paper chip has a stable structure, and the transportation speed of the fluid in the microfluidic paper chip can be flexibly controlled through the regulation of ultraviolet light or pH value. or medical tests with multi-step reactions.

Description

technical field [0001] The invention relates to the field of microfluidic chips used for medical testing, in particular to a microfluidic paper chip with controllable fluid transport and a preparation method and use method thereof. Background technique [0002] The microfluidic chip is a micro total analysis system that combines functional components such as micro pumps, micro valves, micro pipes, micro liquid reservoirs, micro detection elements, micro electrodes, windows and connectors on chip materials using micro processing technology. , has the advantages of less consumables, high degree of automation, high integration and fast detection speed. Microfluidic paper chips, proposed by Professor Whitesides of Harvard University in the United States in 2007, have become the latest development direction in microfluidic chips. Compared with traditional microfluidic chips based on silicon, glass and plastic, microfluidic paper chips have the following main advantages: (1) low ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00
CPCB01L3/5027B01L3/502707B01L2300/161B01L2400/00B01L2400/04B01L2400/0454
Inventor 李薇王巍覃程荣王双飞
Owner GUANGXI UNIV
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