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Application of 6-fluoroimidazopyridine derivative

A technology of fluimidazole and derivatives, which is applied in the field of organic compounds, can solve the problems of general bactericidal effect, skin damage, single function, etc., and achieve the effect of improving bacteriostatic efficiency, high safety, and increasing bactericidal speed

Inactive Publication Date: 2018-12-18
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In summary, most of the hand sanitizers in the prior art have single functions, average bactericidal effect, high cost, and even damage to the skin. Therefore, a hand sanitizer with multiple functions of decontamination, sterilization and skin care is needed. liquid

Method used

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  • Application of 6-fluoroimidazopyridine derivative
  • Application of 6-fluoroimidazopyridine derivative
  • Application of 6-fluoroimidazopyridine derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1, a kind of antibacterial hand sanitizer

[0036] Described antibacterial hand sanitizer, is made up of following component and mass percentage thereof:

[0037] Moisturizing agent 10%, cationic surfactant 0.5%, nonionic surfactant 0.5%, anionic surfactant 15%, thickener 1%, essence 0.1%, bacteriostat 2.4%, antioxidant 0.5%, pH adjustment agent 2%, deionized water 68%; the antibacterial agent is composed of honeysuckle essential oil and 6-fluoroimidazopyridine derivatives described in formula I in a mass ratio of 7:3.

[0038] The humectant is composed of propylene glycol and sorbitol in a mass ratio of 5:2; the cationic surfactant is cocoyl diethanolamine; the nonionic surfactant is lauryl glucoside; the anionic surfactant It is fatty acid sodium; the thickener is hydroxyethyl cellulose; the essence is composed of bee flower essential oil and eugenol in a mass ratio of 4:1; the antioxidant is composed of ascorbic acid and grape seed oil in a mass ratio of ...

Embodiment 2

[0043] Embodiment 2, a kind of antibacterial hand sanitizer

[0044] Described antibacterial hand sanitizer, comprises following component and mass percentage thereof:

[0045] Moisturizing agent 20%, cationic surfactant 2%, nonionic surfactant 2%, anionic surfactant 30%, thickener 3%, fragrance 0.9%, bacteriostatic agent 3.6%, antioxidant 1.5%, pH adjustment agent 5%, deionized water 32%; the antibacterial agent is composed of honeysuckle essential oil and 6-fluoroimidazopyridine derivatives described in formula I in a mass ratio of 7:6.

[0046] The humectant is composed of propylene glycol and sorbitol in a mass ratio of 5:4; the cationic surfactant is coconut oil diethanolamine; the nonionic surfactant is lauryl glucoside; the anionic surfactant It is fatty acid sodium; the thickener is hydroxyethyl cellulose; the essence is composed of bee flower essential oil and eugenol in a mass ratio of 4:3; the antioxidant is composed of ascorbic acid and grape seed oil in a mass ra...

Embodiment 3

[0051] Embodiment 3, a kind of antibacterial hand sanitizer

[0052] A kind of antibacterial hand sanitizer, comprises following component and mass percentage thereof:

[0053] Moisturizing agent 13%, cationic surfactant 0.9%, nonionic surfactant 1.3%, anionic surfactant 20%, thickener 2.5%, fragrance 0.8%, bacteriostatic agent 2.8%, antioxidant 1.2%, pH adjustment Agent 2.3%, deionized water 58%; the antibacterial agent is composed of honeysuckle essential oil and 6-fluoroimidazopyridine derivatives described in formula I in a mass ratio of 7:4.

[0054] The humectant is composed of propylene glycol and sorbitol in a mass ratio of 5:2; the cationic surfactant is cocoyl diethanolamine; the nonionic surfactant is lauryl glucoside; the anionic surfactant It is fatty acid sodium; the thickener is hydroxyethyl cellulose; the essence is composed of bee flower essential oil and eugenol in a mass ratio of 4:3; the antioxidant is composed of ascorbic acid and grape seed oil in a mass...

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PUM

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Abstract

The invention belongs to the field of application of organic compounds and particularly relates to application of a 6-fluoroimidazopyridine derivative. The 6-fluoroimidazopyridine derivative expressedas a formula I can be applied to preparation of bacteria killing and inhibiting articles for daily use; the formula I is as shown in description; the 6-fluoroimidazopyridine derivative is also applied to bacteria-inhibiting hand washing liquid; the bacteria-inhibiting hand washing liquid has multiple functions of removing stains, killing bacteria, protecting skin and inhibiting bacteria; meanwhile, the bacteria-inhibiting hand washing liquid has a good allergy-resisting effect, is high in safety and also has a good application prospect.

Description

technical field [0001] The invention belongs to the field of use of organic compounds, in particular to the use of a 6-fluoroimidazopyridine derivative. Background technique [0002] Imidazolopyridine derivatives are artificially synthesized compounds, which are mainly used as intermediates and active ingredients of antihypertensive and anticancer drugs. Studies have shown that such compounds also have a strong effect of eliminating bacteria, fungi and viruses. Therefore, it is also used in anti-inflammatory drugs. Among them, Chinese patent application CN1646530A discloses a series of nitrosylated imidazopyridines, which have gastric secretion inhibition, anti-inflammatory and antibacterial properties. [0003] Experts believe that diseases can be transmitted through the nose, mouth, eyes, hands, etc. In order to prevent diseases comprehensively, washing hands frequently is the best way. In the past, soap was a daily necessities for people to wash their hands, but with the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/92A61K8/67A61K8/49A61K8/34A61Q19/10A61Q17/00A61Q19/00A61Q19/02A61P31/02A61P31/04A61P31/12A61P37/08A61P29/00
CPCA61K8/347A61K8/4946A61K8/676A61K8/922A61K2800/592A61K2800/5922A61P29/00A61P31/02A61P31/04A61P31/12A61P37/08A61Q17/005A61Q19/00A61Q19/02A61Q19/10Y02A50/30
Inventor 曹华郭鹏峰陈龙斌
Owner GUANGDONG PHARMA UNIV
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