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Application of selenium element for preparing drug capable of relieving toxic and side effects caused by chemotherapeutic drug

A technology of selenium element and chemotherapeutic drugs, applied in the field of biomedicine, can solve the problems of reducing the curative effect of anti-cancer treatment, reducing the side effects of anti-cancer treatment, etc., and achieve the effect of improving the quality of life, reducing side effects, and reducing side effects

Inactive Publication Date: 2018-12-11
ANHUI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is known that TSP-1 antibody or inhibition of TSP-1 / CD47 signaling pathway can reduce the toxic and side effects of anticancer therapy without reducing the efficacy of anticancer therapy
However, there are no reports of this

Method used

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  • Application of selenium element for preparing drug capable of relieving toxic and side effects caused by chemotherapeutic drug
  • Application of selenium element for preparing drug capable of relieving toxic and side effects caused by chemotherapeutic drug
  • Application of selenium element for preparing drug capable of relieving toxic and side effects caused by chemotherapeutic drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Nano-selenium inhibits p53 and TSP-1 effects

[0024] Experimental animals: male Kunming rats, weighing 25-26g. Dosing regimen: 32 mice were randomly divided into 4 groups, 8 in the control group and 24 in the nano-selenium treatment group. On day 0 and day 2, normal saline and 6 mgSe / kg nano-selenium were administered to the control group and nano-selenium treatment group, respectively. On the 5th day, the control group was sacrificed by dislocation. On the 3rd day, the 5th day and the 7th day (24h, 72h, 120h after the second gavage), 8 mice were randomly selected from the nano-selenium treatment group and killed by dislocation. After the mice were sacrificed, the small intestines were removed, and gene expression was detected by fluorescent quantitative PCR.

[0025] Experimental results and conclusions: figure 1 A shows that the p53 gene of the small intestine and the genes regulated by it (p21, Xpc, XPE, Bax) were significantly down-regulated after nan...

Embodiment 2

[0026] Example 2 Chemotherapy up-regulates intestinal p53 and TSP-1 effects

[0027] Experimental animals: male Kunming rats, weighing 26-28g. Dosing regimen 1: 13 mice were randomly divided into 2 groups, 6 in the control group and 7 in the cisplatin group. On day 0 and day 2, normal saline and cisplatin (9 mg / kg) were intraperitoneally injected into the two groups, respectively. All mice were sacrificed on day 5. Dosing regimen 2: 23 mice were randomly divided into 2 groups, 5 in the control group and 18 in the nedaplatin group. On day 0 and day 2, normal saline and nedaplatin (33 mg / kg) were intraperitoneally injected into the two groups respectively. On the 4th day, the mice in the control group were sacrificed; on the 3rd, 4th and 5th day (24h, 48h, 72h after the second injection of nedaplatin), 6 mice were randomly selected to be sacrificed. After the mice were sacrificed, the small intestines were taken, and TSP-1 and p53-related proteins were detected by Western Bl...

Embodiment 3

[0029] Example 3 Nano selenium reduces the toxic and side effects of chemotherapeutics by inhibiting the upregulation of p53 and TSP-1 induced by chemotherapeutics

[0030] Experimental animals: male Kunming rats, weighing 27-29g. Dosing regimen: 12 mice were randomly divided into 3 groups, 4 mice in the control group, 4 mice in the nedaplatin group, and 4 mice in the nano-selenium group. On the 0th day and the 2nd day, the nedaplatin group and the nano-selenium group were given normal saline and 6mg Se / kg nano-selenium, respectively, and half an hour later, both groups were intraperitoneally injected with nedaplatin (33mg / kg). On the 5th day, all the mice were sacrificed, and the small intestines of the mice were taken after sacrifice, and TSP-1 and p53-related proteins were detected by Western Blot. The state and body weight of the mice were observed every day, and the diarrhea was recorded.

[0031] Experimental results and conclusions: image 3 A shows that nedaplatin t...

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Abstract

The invention relates to application of a selenium element for preparing a drug capable of relieving toxic and side effects caused by a chemotherapeutic drug. The selenium element is capable of targeted-inhibiting a p53 signal channel and a TSP-1 / CD47 signal channel, thereby reducing the toxic and side effects of the chemotherapeutic drug through inhibiting p53 and TSP-1 up-regulation expression induced by the chemotherapeutic drug, without affecting the curative effect of the chemotherapeutic drug. The application provides a new way for effectively relieving the toxic and side effects of a cancer patient caused by the chemotherapeutic drug, and improving quality of life of the patient.

Description

technical field [0001] The field of biomedicine of the present invention, specifically, relates to the application of selenium element in the preparation of medicines for alleviating the toxic and side effects caused by chemotherapeutic drugs. Background technique [0002] Chemotherapy is the most common means of treating cancer. Chemotherapy can suppress tumors, but it can also have toxic side effects. Selective protective agents that protect normal tissue but not tumors are therefore sought. The toxic and side effects of chemotherapy are related to the upregulation of p53 and thrombospondin 1 (TSP-1) in normal tissues. It is known that inhibiting the p53 or TSP-1 / CD47 signaling pathway alone can reduce the toxic side effects of anticancer therapy, but does not interfere with the efficacy of anticancer therapy. Therefore, p53 or TSP-1 / CD47 signaling pathway is considered as a selective target to reduce the toxic side effects of anticancer therapy. Known p53 inhibitors (...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/04A61K31/198A61K45/06A61P1/12A61P3/00A61P35/00
CPCA61K31/198A61K33/04A61K45/06A61P1/12A61P3/00A61P35/00A61K2300/00
Inventor 张劲松
Owner ANHUI AGRICULTURAL UNIVERSITY
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