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QCM-based sensor for detecting 1,5-anhydroglucitol, and detection method thereof

An anhydroglucitol and sensor technology, which is applied in the field of sensors for detecting 1,5-anhydroglucitol, can solve the problems of complicated operation, easy inactivation, and large volume of chromatographic instruments, and achieve portability, simple operation, and small size Effect

Active Publication Date: 2018-11-30
中科康磁医疗科技(苏州)有限公司
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Problems solved by technology

Chromatography instruments are large in volume, long in analysis time, and complicated in operation. Enzyme methods are prone to bacterial contamination, poor in stability, easy to inactivate, and high in price

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  • QCM-based sensor for detecting 1,5-anhydroglucitol, and detection method thereof
  • QCM-based sensor for detecting 1,5-anhydroglucitol, and detection method thereof
  • QCM-based sensor for detecting 1,5-anhydroglucitol, and detection method thereof

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Embodiment Construction

[0028] The objects and functions of the present invention and methods for achieving the objects and functions will be clarified by referring to the exemplary embodiments. However, the present invention is not limited to the exemplary embodiments disclosed below; it can be implemented in various forms. The essence of the description is only to help those skilled in the relevant art comprehensively understand the specific details of the present invention.

[0029] Hereinafter, embodiments of the present invention will be described with reference to the accompanying drawings. In the drawings, the same reference numerals represent the same or similar components, or the same or similar steps.

[0030] The preparation process of the sensor of the present invention is: first chemically modify a layer of chemical substances on the quartz crystal oscillator, which contains polymerizable functional groups, and then perform polymer polymerization on the chemical substances to modify a c...

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Abstract

The invention discloses an QCM-based sensor for detecting 1,5-anhydroglucitol, and a detection method thereof. The QCM-based sensor adopts a sensor made of a quartz crystal, and has the advantages ofsmall size, portability and simplicity in operation. The method adopted in the invention is characterized in that a phenylboronic acid chemical substance is used as a 1,5-AG identification unit, and the phenylboronic acid chemical substance is combined with QCM to improve the reaction efficiency of the 1,5-AG and realize real-time online detection.

Description

technical field [0001] The invention relates to the technical field of biological detection, in particular to a QCM-based sensor and detection method for detecting 1,5-anhydroglucitol. Background technique [0002] 1,5-anhydroglucitol (1,5-AG) is an indicator that has gradually attracted attention in recent years for diagnosing diabetes and monitoring blood glucose levels in patients. The 1,5-AG level is not affected by factors such as the patient's age, course of disease, diet, and exercise. Compared with the fasting blood glucose and 2h postprandial blood glucose detection recommended by the American Diabetes Association, it is stable and accurate. Compared with glycosylated hemoglobin, it can detect The sensitivity and specificity of blood glucose fluctuations and hyperglycemia exceeding the renal glucose threshold in patients with DM in the near future (3-7 days) are higher than those of blood glucose, HbA1c and glycosylated serum albumin. 1,5-AG is at a low level in th...

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Application Information

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IPC IPC(8): G01N21/33G01N5/00
CPCG01N5/00G01N21/33
Inventor 戴庆
Owner 中科康磁医疗科技(苏州)有限公司
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