Water-soluble tilmicosin florfenicol compound injection and preparation method and application thereof

A technology of fenofenil and tilmicosin, which is applied in the field of water-soluble tilmicosin florfenicol compound injection and its preparation, can solve the problems of low utilization rate, fetal toxicity, immunosuppression and anorexia, etc. To achieve the effect of less toxic and side effects, reduce cardiotoxicity and fast absorption

Inactive Publication Date: 2018-11-23
广东正大康生物科技股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Florfenicol is insoluble in water and has a low utilization rate. Large doses must be used (20-30 mg for oral administration per 1 kg of body weight, and 15-20 mg for injection), and repeated administration is required every 24 hours. There are disadvantages such as fetal toxicity, immunosuppression and anorexia

Method used

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  • Water-soluble tilmicosin florfenicol compound injection and preparation method and application thereof
  • Water-soluble tilmicosin florfenicol compound injection and preparation method and application thereof
  • Water-soluble tilmicosin florfenicol compound injection and preparation method and application thereof

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Embodiment 1

[0027] Embodiment 1: Preparation of water-soluble tilmicosin florfenicol compound injection

[0028] According to the formulation in Table 1 below, the water-soluble tilmicosin florfenicol compound injection was prepared.

[0029] Table 1 The formula table of water-soluble tilmicosin florfenicol compound injection

[0030] Reagent

mass fraction%

Density(20℃)(g / ml)

Tilmicosin

6

Florfenicol

2

Isopropyl myristate

4.7

0.850～0.860

Tween 80 (surfactant)

25.2

1.060～1.110

Absolute ethanol (co-surfactant)

11.2

0.789～0.791

1,2-Propanediol (co-surfactant)

5.6

1.036～1.039

dimethylformamide

1.6

0.94～

phosphoric acid

1.5

distilled water

margin

1.000

[0031] Concrete preparation steps are as follows:

[0032] At 25°C, mix Tween 80, absolute ethanol, 1,2-propanediol and phosphoric acid, and then add tilmicosin while stirring to completely dissolve ...

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Abstract

The invention provides water-soluble tilmicosin florfenicol compound injection, which comprises the following ingredients in percentage by mass: tilmicosin, florfenicol, isopropyl myristate, a surfactant, a cosurfactant, a solvent, phosphoric acid and rest water. The water-soluble tilmicosin florfenicol compound injection has the advantages of high water solubility, high bioavailability, good stability and high antibacterial activity.

Description

technical field [0001] The invention belongs to the field of veterinary medicines, in particular to a water-soluble tilmicosin florfenicol compound injection and a preparation method and application thereof. Background technique [0002] Tilmicosin (TMS) is a special livestock and poultry antibiotic synthesized from tylosin, which belongs to the third class of new veterinary drugs in the country. Tilmicosin is a derivative of tylosin after acid hydrolysis, which belongs to semi-synthetic macrolide antibiotics, and its molecular formula is C 46 h 80 N 2 o 13 , molecular weight 869.15. Tilmicosin has similar antibacterial activity to macrolides, and is effective against Gram-positive bacteria and some Gram-negative bacteria and mycoplasma, especially against Actinobacillus pleuropneumoniae, Pasteurella, golden yellow Staphylococcus, Streptococcus pyogenes, Streptococcus pneumoniae, Corynebacterium pyogenes and Mycoplasma pyogenes are more active than tylosin. There is no...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/14A61K47/04A61K31/706A61K31/165A61P31/04
CPCA61K9/0019A61K9/1075A61K31/165A61K31/706A61K47/02A61K47/14A61P31/04A61K2300/00
Inventor 郑闳升张友春王丙云
Owner 广东正大康生物科技股份有限公司
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