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The new application of antifungal medicine in the control of crop diseases

A technology of antifungal drug and disease control, applied in the field of agricultural fungicides

Active Publication Date: 2021-01-29
YANGTZE UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main use of fluconazole is medical, such as the Chinese patent "A fluconazole ophthalmic preparation", application number 201711062031, such as "A fluconazole ear drops and its preparation method", application number 201711100270.x , another example is "fluconazole dispersible tablet and its preparation method", application number 201110433079.3; and the use of fluconazole for the prevention and treatment of crop diseases has not been reported yet

Method used

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  • The new application of antifungal medicine in the control of crop diseases
  • The new application of antifungal medicine in the control of crop diseases
  • The new application of antifungal medicine in the control of crop diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the inhibitory effect of fluconazole to 3 kinds of fungal hyphae

[0013] Using the mycelial growth rate method, use a puncher with a diameter of 5mm to cut the bacteria cake from the edge of the colony under aseptic conditions, and inoculate the bacteria cake in the center of the drug-containing medium plate with an inoculation needle. , with the mycelium facing down, cover the dish, turn it upside down, and place it in a 25°C incubator for cultivation. When the colonies in the blank control are overgrown to about two-thirds of the plate area, measure the colony diameter of each treatment with the cross method. Each sample was repeated 3 times and the average value was taken. The ratio of the difference between the colony diameter of the blank control and the colony diameter of the drug treatment to the colony diameter of the blank control was used to calculate the mycelial growth inhibition rate of each drug treatment on the pathogenic bacteria. The inh...

Embodiment 2

[0020] Embodiment 2: the inhibitory effect of fluconazole to 4 kinds of pathogenic bacteria

[0021] Using the mycelial growth rate method, the method is the same as above, and the inhibitory effect of fluconazole on 4 kinds of pathogenic bacteria, Bletilla striata striata, apple spot leaf spot, corn small spot, and peanut root rot, is determined, and the concentration of fluconazole used is 0.2 mmol / L, the specific test results are shown in Table 3.

[0022] Table 3 The inhibitory effect of fluconazole on 4 kinds of fungal hyphae

[0023]

[0024] From the test results, it can be seen that fluconazole has a certain inhibitory effect on bletilla striata striata, apple spotted leaf spot, corn leaf spot, and peanut root rot.

Embodiment 3

[0025] Embodiment 3: Pot control effect of fluconazole on wheat powdery mildew

[0026] Using the pot method, sow wheat in plastic pots, spray fluconazole when the wheat develops to the 3-leaf stage, the dosage of active ingredients is 15 g / ha, 45 g / ha, and the control agent is a conventional chemical agent for preventing and treating wheat powdery mildew Hexaconazole, the dosage is the same as that of fluconazole. 24 hours after the spraying, the wheat powdery mildew pathogen was inoculated. When the wheat powdery mildew occurred obviously in the blank group, the disease index was investigated and the control effect was calculated. The specific results are shown in Table 4.

[0027] Table 4 Pot control effect of fluconazole on wheat powdery mildew

[0028]

[0029] It can be seen from the test results that fluconazole has an excellent control effect on wheat powdery mildew, and the control effect is also significantly improved with the increase of the dosage; All of them...

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Abstract

The invention discloses a novel application of an antifungal medicine to prevention and control of crop diseases and belongs to the field of agricultural fungicides. The antifungal medicine is fluconazole and can prevent and control rice sheath blight disease, tomato early blight, rice blast, wheat powdery mildew, wheat stripe rust, rhizoma bletillae southern blight, apple alternaria leaf spots, bipolaris maydis and peanut root rot. Discovered that the fluconazole is relatively high in activity to various crop fungal diseases, the activities of some fluconazole are even higher than the activities of the triazole agricultural commercial fungicide used now, and the fluconazole can realize the novel application to prevention and control of the crop diseases.

Description

technical field [0001] The invention relates to the field of agricultural fungicides, in particular to the new application of the antifungal drug fluconazole as a fungicide in the prevention and control of crop diseases. Background technique [0002] Fluconazole (Fluconazole, HFlu), trade name Difucan (Difucan), chemical name: α-(2,4-difluorophenyl)-α-(1H-1,2,4-triazole-1 -ylmethyl)-1H-1,2,4-triazol-1-ylethanol, molecular formula: C 13 h 12 f 2 N 6 O, molecular weight: 306.28, is a triazole antifungal drug, developed and synthesized by Pfizer of the United States in 1980, and began to be produced and used in clinical practice in China in 1992. It is white or off-white crystal or crystalline powder, odorless or slightly specific odor, Bitter, easily soluble in methanol and ethanol, slightly soluble in dichloromethane, water or acetic acid, insoluble in ether. Melting point: 137-141°C. Fluconazole inhibits or kills fungi by competitively inhibiting the synthesis of ergos...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/653A01P3/00
CPCA01N43/653
Inventor 徐志红张敏李俊凯
Owner YANGTZE UNIVERSITY
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