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Application of yellow sole b in preparation of medicine for treating nodular goiter

A goiter and nodular technology, applied in the direction of drug combinations, pharmaceutical formulas, organic active ingredients, etc., can solve the problems of high recurrence rate, high toxicity and side effects, and unsatisfactory treatment effect, so as to reduce the degree of nodules and achieve good treatment The effect of improving thyroid hormone and antibody levels

Active Publication Date: 2020-06-05
SHANDONG ACAD OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine generally treats thyroid nodules by taking thyroid drugs, hormones or surgery, but the recurrence rate is high, the side effects are large, and the treatment effect is not ideal

Method used

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  • Application of yellow sole b in preparation of medicine for treating nodular goiter
  • Application of yellow sole b in preparation of medicine for treating nodular goiter
  • Application of yellow sole b in preparation of medicine for treating nodular goiter

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The extraction of embodiment 1 lutein B

[0028] Take 1.75 kg of Xanthophyllum medicinal material, add 6 times the amount of 75% ethanol, heat and reflux in a water bath to extract 3 times, each time for 2 hours, filter the extract, combine and concentrate the filtrate until it has no alcohol smell, and obtain 315 g of extract, add an equal amount of diatomaceous earth Mix the sample and dry under reduced pressure at 50°C. Add 3 times the amount of petroleum ether to the dried silica gel sample, heat and reflux in a water bath to extract 3 times, each time for 1 hour, and filter the extract. Evaporate the filter residue to dryness under reduced pressure, add 6 times the amount of dichloromethane, heat and reflux for extraction 6 times, 1 hour each time, filter the extract, combine the filtrates and evaporate to dryness to obtain 21g of dichloromethane extract, heat and dissolve with a small amount of 95% ethanol , add an equal amount of silica gel for column chromatogr...

Embodiment 2

[0032] Example 2 Effect of Huangdu element B on the appearance of the rat nodular goiter model induced by propylthiouracil

[0033] Pre-experiment preparation

[0034] 60 SD male rats were randomly divided into normal control group, model control group, xanthophyll high, medium and low dose groups, levothyroid sodium tablet group (positive drug control group), 10 rats in each group.

[0035] After one week of feeding, the model was established: the rats in the model group, the high-dose, medium-dose and low-dose groups of xanthophyllum, and the positive drug control group were given 1.5 mg / kg of propylthiouracil (PTU) by intragastric administration every day for 15 consecutive days. Subsequent administration: ①Normal control group: intragastric administration of 10ml / kg of water to rats every day for 30 days; ②Model group: after successful modeling, intragastric administration of 10ml / kg of water for 30 days; High-dose group: gavage at 1.62g / kg for 30 days. ④ Medium-dose Hua...

Embodiment 3

[0038] Example 3 Effects of lutein B on thyroid hormone levels (T3, T4) in rat nodular goiter model induced by propylthiouracil

[0039] The pre-experimental preparations were the same as in Example 2.

[0040] Experimental results

[0041] Determination of T3, T4 levels in serum. The results in Table 2 show that: after the nodular goiter model was created in rats, the T3 and T4 values ​​increased, and after the treatment with lutein B, the above two indicators were observed to decrease. Among them, compared with the model control group, the T3 value has extremely significant difference (P<0.001) in the high, middle and low dose groups of Huangdusu B, and the positive control group has an extremely significant difference (P<0.001); T4 value is compared with the model control group Compared with different groups, there were extremely significant differences (P<0.001) in the high, middle and low dose groups of Xanthophyllum, and extremely significant differences (P<0.001) in t...

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Abstract

The invention investigates therapeutic effects of dioscorea bulbifera extract, namely diosbulbin B, on model rats by establishing models of propylthiouracide (PTU) induced nodular goiter in rats. Thediosbulbin B can achieve effects of greatly improving the thyroid hormone and antibody levels of rats and lowering the nodal degree and has an excellent effect of treating the nodular goiter. The invention further provides an extraction method of the diosbulbin B, and an experimental foundation is laid for developing new drugs for treating the nodular goiter.

Description

technical field [0001] The invention relates to the new application field of the yellow sole B, in particular to the application of the yellow sole B in preparing a medicine for treating nodular goiter. Background technique [0002] Thyroid disease is a high incidence of endocrine system disorders, in which thyroid nodules are the third stage of goiter, there is a risk of transformation into thyroid cancer. There is an urgent need to find low-toxicity and high-efficiency drugs to cure this disease. In recent years, the incidence of thyroid disease in my country has become higher and higher, and the prevalence rate in the general population is about 4%, which has increased by nearly 4 times compared with 10 years ago. [0003] Nodular goiter can be divided into two stages. Single nodules are generally considered to be the initial symptoms of nodular goiter, while multiple nodules are considered to be its late manifestations and have the possibility of precancerous lesions. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61P5/14C07D493/20
CPCA61K31/365A61P5/14C07D493/20
Inventor 闫雪生王平于蓓蓓孙丹丹张丽美
Owner SHANDONG ACAD OF CHINESE MEDICINE
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