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A kind of isotope dilution quantitative detection method

A quantitative detection method, isotope dilution technology, applied in the field of analysis and testing

Active Publication Date: 2020-10-09
NORTHWEST INST OF NUCLEAR TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0021] The purpose of the present invention is to solve the problem that additional measurement steps are required to accurately measure the content of various isotopes derived from artificial additives under the condition that the isotope ratio of the sample to be tested after adding artificial additives to the original sample is affected. A quantitative detection method of isotope dilution, this method is suitable for the quantitative test of isotope dilution method with multiple isotopes, under the condition of pre-calibrating relevant parameters, after obtaining the sample, it only needs a single measurement to determine the content of multiple isotopes in artificial additives ; Of course, if necessary, the content of other various isotopes in the sample can also be determined

Method used

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  • A kind of isotope dilution quantitative detection method
  • A kind of isotope dilution quantitative detection method
  • A kind of isotope dilution quantitative detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0116] For example, to test bioabsorption effects, take 147 Sm is used as an isotopic tracer, and there is a small amount of natural Sm in the environment, which contains 147 Sm, 148 Sm, 149 Sm, 150 Sm, 152 Sm, 154 Sm and other isotopes of natural abundance, the isotope to be measured is the isotope from the added tracer in the sample 147 Sm.

[0117] The three isotopes A, B, and C correspond to 150 Sm, 147 Sm, 152 Sm, select 152 Sm is the representative isotope of natural Sm.

[0118] According to the conventional isotope dilution method, because in the sample 147 The abundance of Sm is not a natural abundance and is an unknown quantity. Therefore, the abundance test of the sample must be carried out. In order to omit the abundance test step of the sample, the following steps are used for measurement:

[0119] 1) select 150 Sm is used as an isotope diluent, and its addition amount is accurately calibrated, and it is determined when the isotope diluent is calibrat...

Embodiment 2

[0126] In Example 1, if added in the experiment 147 Sm isotope tracer, containing 1% 150 Sm (i.e. the tracer contains an isotope of the element Sm 147 Sm and isotopes 150 Sm), other parameters are the same as above. Then in R 147X On the basis that 1% is known, the measurement conditions and contents are the same as those in Example 1. According to the formulas (14), (15), and (16), only one measurement is still needed to give the sample at the same time due to the added indication. tracer 150 Sm, 147 The amount of two isotopes of Sm.

[0127]

[0128]

[0129] in:

[0130]

Embodiment 3

[0132] In Example 1, if the experiment also added 149 Sm isotope tracer (i.e. isotope with undisturbed abundance 149 Sm instead 150 Sm), then only need to add in the calibration and subsequent measurement 149 The measurement of Sm ion current still only needs one measurement, and it can also give the tracer in the sample at the same time. 147 Sm, 149 The amount of two isotopes of Sm, 147 The amount of Sm has been given in embodiment one, 149 The amount of Sm isotope is shown in the following formula.

[0133]

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Abstract

Relating to the analytical test field, the invention provides an isotope dilution quantitative detection method directed at the problem of needing an additional measurement step under the condition ofan affected to-be-detected sample's isotope ratio after adding an artificial additive to an original sample. The method is used for measuring the content of isotope B derived from an artificial additive in a to-be-detected sample, which is a mixture obtained by adding the artificial additive to the original sample, wherein the element X in the original sample at least contains isotopes A, B and C; the artificial additive contains the isotope B of element X and does not contain isotope A and isotope C. The method includes the steps of: 1) selecting a concentrated sample of isotope A as the isotope diluent, and calibrating RBD, RCD and the adding amount ND of the isotope diluent; (2) adding the isotope diluent into the to-be-detected sample, and mixing the isotope diluent with the to-be-detected sample uniformly; (3) measuring RBM and RCM; and (4) calculating the atomic number of the isotope B derived from the artificial additive in the to-be-detected sample through a formula.

Description

technical field [0001] The invention relates to the technical field of analysis and testing, in particular to a quantitative detection method for isotope dilution. Background technique [0002] The isotope dilution method is a generally recognized and traceable quantitative analysis method. Assuming that there are two isotopes A and B in a certain element in the sample, by adding an isotope diluent with a large difference in the abundance of A and B in the sample, the mixed isotope is measured. The abundance ratio can be used to calculate the content of isotopes A and B in the sample. [0003] Assuming that the content of isotope B in the sample is higher than that of isotope A (the content of B may also be lower), the concentrated sample of isotope A is selected as the isotope diluent, and the content of other isotopes (impurities) except A in the isotope diluent is usually less than 1 %, that is, the content of A in the isotopic diluent is much higher than that of B; in g...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N1/38G01N33/00
CPCG01N1/38G01N33/00G01N2001/388
Inventor 韦冠一方随徐江汪伟李雪松李志明袁祥龙
Owner NORTHWEST INST OF NUCLEAR TECH
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