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Humidity responding artificial skin and preparation method and applications thereof

A technology of artificial skin and humidity response, applied in the field of biomedical biomimetic materials, can solve the problems of inability to simulate the mechanical properties of skin in different hydration states, and achieve the effects of easy preparation, convenient quality control, and simple steps

Inactive Publication Date: 2018-11-16
SHANGHAI ADVANCED RES INST CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main technical problem to be solved is: the artificial skin of the prior art can only simulate the mechanical properties of a single type of skin, and cannot simulate the mechanical properties of skin in different hydration states

Method used

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  • Humidity responding artificial skin and preparation method and applications thereof
  • Humidity responding artificial skin and preparation method and applications thereof
  • Humidity responding artificial skin and preparation method and applications thereof

Examples

Experimental program
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preparation example Construction

[0057] The present invention also provides a method for preparing the above humidity-responsive artificial skin, comprising the following steps:

[0058] (1) Preparation of artificial skin precursor:

[0059] Add a certain amount of hydrophilic compound and a certain amount of water into the three-necked flask, stir until dissolved at 25-90°C, after cooling, let stand or vacuum defoam, then add a certain amount of coupling agent to it, stir Uniformly obtained hydrophilic network precursors. Then, the siloxane and its cross-linking agent in a certain mass ratio were mixed and stirred for 15-20 minutes to obtain the lipophilic network precursor. Finally, mixing and stirring the lipophilic network precursor and the hydrophilic network precursor in a certain mass ratio for 10 to 30 minutes, standing still or vacuum defoaming to obtain the artificial skin precursor.

[0060] (2) Preparation of artificial skin membrane:

[0061] The artificial skin precursor is spin-coated or scr...

Embodiment 1

[0073] Preparation chitosan aqueous solution, the mass ratio of chitosan and water is 7:80, stirs to dissolving at room temperature, then vacuum defoaming, then adds coupling agent glutaraldehyde (the mixture of chitosan and glutaraldehyde) wherein The mass ratio is 1:0.2), and stirred evenly to obtain a hydrophilic network precursor.

[0074] Dow Corning 184 polydimethylsiloxane with a mass ratio of 65:1 and a crosslinking agent were mixed and stirred for 15 minutes to obtain a lipophilic network precursor.

[0075] Add the hydrophilic network precursor to the lipophilic network precursor, wherein the mass percentage of the hydrophilic network precursor is 50%, mix and stir for 5min at 500rpm, then add 1.5% sodium lauryl sulfate (porogen ), stirred for 15 minutes and then vacuum defoamed to obtain the artificial skin precursor.

[0076] The above-mentioned artificial skin precursor is cast into a film in a mold, and the thickness of the liquid embryo film is 2.0mm. Then, th...

Embodiment 2

[0082] Preparation chitosan aqueous solution, its mass ratio with water is 7:80, stirs to dissolving at room temperature, then leaves standstill defoaming, then adds coupling agent glutaraldehyde (the quality of chitosan and glutaraldehyde) wherein The ratio is 1:0.2), and stir evenly to obtain a hydrophilic network precursor.

[0083] Mix and stir the lipophilic network precursor Dow Corning 184 polydimethylsiloxane and the crosslinking agent at a mass ratio of 50:1 for 15 minutes to obtain the lipophilic network precursor.

[0084] Add the hydrophilic network precursor to the lipophilic network precursor, mix and stir for 5 minutes at 500rpm, wherein the mass percentage of the hydrophilic network precursor is 50%, then add 1.5% sodium sulfate, stir, and let it stand for 15 minutes to remove bubble to obtain the artificial skin precursor.

[0085] The above-mentioned artificial skin precursor was cast into a film in a mold, and the thickness of the liquid embryo film was 2.0...

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Abstract

The invention discloses a humidity responding artificial skin and a preparation method and applications thereof. The artificial skin is composed of following components in percentage by weight: 10 to49.5% of hydrophilic network, 50 to 89.5% of oleophylic network, and 0.5 to 1.5% of pore-forming agent. The hydrophilic network is composed of a hydrophilic compound and water according to a mass ratio of 7-20:80 and also comprises a coupling agent, wherein the mass ratio of the coupling agent to the hydrophilic compound is 0-0.2:1. The oleophylic network is obtained through polymerization betweenorganic silicon and a crosslinking agent, wherein the mass ratio of organic silicon to the crosslinking agent is 10-80:1, the organic silicone is siloxane containing vinyl, and the crosslinking agentis siloxane containing Si-H bonds. By combining the hydrophilic network and the oleophylic network, thus the prepared artificial skin can absorb water and respond to humidity; and compared with silica gel skin, the artificial skin can absorb a large amount of water and can simulate the functions of wet skin and dry skin at the same time.

Description

technical field [0001] The invention belongs to the technical field of bionic materials for biomedical use, and in particular relates to a humidity-responsive artificial skin and its preparation method and application. Background technique [0002] The skin is the largest organ of the human body and has important physical, chemical and biological barrier functions. In daily life, due to the needs of labor, exercise, health care, beauty, and warmth, human skin cannot do without contact and friction with various other materials. These interactions will involve many skin problems, such as the comfort of contact and friction between the skin and textile fiber materials, skin care products, etc., the abrasion and blistering phenomenon between the skin and labor production tools, sporting goods, etc., and the skin and medical equipment. Patients with pain and tissue damage problems. Therefore, the study of contact and frictional interactions between skin and different products a...

Claims

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Application Information

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IPC IPC(8): A61L27/60A61L27/56G09B23/28
CPCA61L27/56A61L27/60G09B23/28
Inventor 曾祥琼陈景民李久盛
Owner SHANGHAI ADVANCED RES INST CHINESE ACADEMY OF SCI
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