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Assistant hpyerglycemic tablet and production method thereof

A production method and a hypoglycemic technology, applied in the field of medicine, can solve the problems of drug resistance, obvious side effects, large dosage, etc., and achieve the effect of inhibiting the release of glutamate, excellent hypoglycemic effect, and improving hypoglycemic effect.

Inactive Publication Date: 2018-11-16
山东国和堂制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these drugs have different mechanisms of action to help diabetics control blood sugar levels, these drugs also have shortcomings: the mode of action / way is single, and they all have different degrees of side effects, and the side effects are more obvious when taken in large doses or taken for a long time , there will be drug resistance

Method used

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  • Assistant hpyerglycemic tablet and production method thereof
  • Assistant hpyerglycemic tablet and production method thereof
  • Assistant hpyerglycemic tablet and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A kind of production method of auxiliary hypoglycemic tablet, comprises the following steps:

[0031] (1) co-micronizing Jerusalem artichoke powder, kudzu root and microcrystalline cellulose with a mass ratio of 2:2:200, so that more than 90% of the particles have a particle size within 70 μm;

[0032] (2) L-glutamic acid, stachyose, sodium carboxymethylcellulose, and light calcium carbonate are respectively passed through a 100-mesh sieve, and then mixed with a mass ratio of 1:2:6:5 to obtain a mixed powder;

[0033] (3) Mix the Inonotus obliquus micropowder, the co-micronized product of step (1) and the mixed powder obtained in step (2) according to a mass ratio of 1:150:20, add a binder, and make soft material granulation;

[0034] (4) dry granules are obtained after wet granules are dried;

[0035] (5) After the dry granules are sized, magnesium stearate and silicon dioxide are added, mixed together, and compressed into tablets to obtain the product;

[0036] Wher...

Embodiment 2

[0047] A kind of production method of auxiliary hypoglycemic tablet, comprises the following steps:

[0048] (1) co-micronizing Jerusalem artichoke powder, kudzu root and microcrystalline cellulose with a mass ratio of 3:3:250, so that more than 90% of the particles have a particle size within 70 μm;

[0049] (2) L-glutamic acid, stachyose, sodium carboxymethylcellulose, and light calcium carbonate are respectively passed through a 100-mesh sieve, and then mixed with a mass ratio of 1:3:7:6 to obtain a mixed powder;

[0050] (3) Mix the Inonotus obliquus micropowder, the co-micronized product of step (1) and the mixed powder obtained in step (2) according to a mass ratio of 1:180:30, add a binder, and make soft material granulation;

[0051] (4) dry granules are obtained after wet granules are dried;

[0052] (5) After the dry granules are sized, magnesium stearate and silicon dioxide are added, mixed together, and compressed into tablets to obtain the product;

[0053] Wher...

Embodiment 3

[0064] A kind of production method of auxiliary hypoglycemic tablet, comprises the following steps:

[0065] (1) co-micronizing Jerusalem artichoke powder, kudzu root and microcrystalline cellulose with a mass ratio of 2:3:200, so that more than 90% of the particles have a particle size within 70 μm;

[0066] (2) L-glutamic acid, stachyose, sodium carboxymethylcellulose, and light calcium carbonate are respectively passed through a 100-mesh sieve, and then mixed with a mass ratio of 1:3:7:5 to obtain a mixed powder;

[0067] (3) Mix the Inonotus obliquus micropowder, the co-micronized product of step (1) and the mixed powder obtained in step (2) according to a mass ratio of 1:150:30, add a binder, and make soft material granulation;

[0068] (4) dry granules are obtained after wet granules are dried;

[0069] (5) After the dry granules are sized, magnesium stearate and silicon dioxide are added, mixed together, and compressed into tablets to obtain the product;

[0070] Wher...

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Abstract

The invention provides an assistant hpyerglycemic tablet and a production method thereof. The assistant hpyerglycemic tablet uses Inonotus obliquus, Jerusalem artichoke powder, Radix Puerariae, L-glutamic acid and stachyose as main raw materials and has excellent hpyerglycemic effect. The production method of the invention comprises the following steps: subjecting the Jerusalem artichoke powder, Radix Puerariae and microcrystalline cellulose to co-micronization; preparing mixed powder from L-glutamic acid, stachyose, sodium carboxymethyl cellulose and light calcium carbonate; then mixing the micropowder of Inonotus obliquus, a co-micronized product and the mixed powder; adding a binder and preparing a soft material; successively carrying out granulation, drying and size stabilization; adding magnesium stearate and silica; and carrying out total mixing and tabletting. The production method of the invention has positive effect on the disintegration speed, dissolution rate and stability of the tablet.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an auxiliary hypoglycemic tablet and a production method thereof. Background technique [0002] Diabetes is caused by genetic factors, immune dysfunction, microbial infection and its toxins, free radical toxins, mental factors and other pathogenic factors acting on the body to cause hypofunction of pancreatic islets and insulin resistance. Clinically, hyperglycemia is the main feature. Typical cases may show polyuria, polydipsia, polyphagia, weight loss, etc., that is, "three more and one less" symptoms. Once diabetes (blood sugar) Poor control will lead to complications, leading to failure of the kidneys, eyes, feet and other parts of the disease, and can not be cured. [0003] At present, the conventional drugs for the treatment of diabetes are mainly oral hypoglycemic drugs and long-term use of insulin. Among them, oral hypoglycemic drugs are mainly sulfonylureas, biguanide...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/488A61K9/20A61K47/38A61P3/10A61K31/198A61K31/702
CPCA61K9/2054A61K31/198A61K31/702A61K36/07A61K36/28A61K36/488A61P3/10A61K2300/00
Inventor 郇玉芝
Owner 山东国和堂制药有限公司
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