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Antioxidant hydrogel for promoting wound healing as well as preparation method and application of antioxidant hydrogel

A technology with antioxidant properties and wound healing, applied in the field of biomedicine, can solve the problems of inability to guarantee the treatment effect, poor compatibility of the hydrogel main chain, poor lipid solubility and water solubility, etc. The effect of drug action time and good air permeability

Active Publication Date: 2018-11-06
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Puerarin molecules have polyhydroxyl and polyphenyl ring structures, resulting in poor fat-solubility and water-solubility, which not only makes it poor oral effect and low bioavailability, but also causes its loading in ordinary hydrogels to be limited. restrictions, which greatly limit its clinical application
In addition, due to the poor compatibility of poorly water-soluble drugs with the hydrophilic hydrogel backbone, the poorly water-soluble drugs embedded in the hydrogel network will be released quickly through osmosis, This does not guarantee the effectiveness of the treatment

Method used

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  • Antioxidant hydrogel for promoting wound healing as well as preparation method and application of antioxidant hydrogel
  • Antioxidant hydrogel for promoting wound healing as well as preparation method and application of antioxidant hydrogel
  • Antioxidant hydrogel for promoting wound healing as well as preparation method and application of antioxidant hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Example 1 Preparation of hydrogel (Gel-3:PEG-DA / PDA / PUE(H))

[0060] 1, the preparation method of hydrogel, comprises the following steps:

[0061] (1) Stir 9 mL of pure water, 4 mL of ethanol, and 0.5 mL of 30% ammonia water in a round bottom flask evenly, then add 20 mg of dopamine powder, and react for 5 h to obtain polydopamine nanoparticles;

[0062] (2) Dissolve 20 mg of puerarin in 0.5 mL of ethanol, then mix well with 10 mL of polydopamine nanoparticle diluent with a concentration of 2 mg / mL, and react for 2 h to obtain a puerarin / polydopamine drug-loaded solution;

[0063] (3) Add 150 mg polyethylene glycol diacrylate (PEG-DA) powder into the above puerarin / polydopamine drug-loading solution, so that the mass ratio of puerarin, polydopamine nanoparticles and polyethylene glycol diacrylate 0.1:1:7.5, wherein the concentration of puerarin / polydopamine drug-loading solution is 10 mg / mL, and the content of PEG-DA is 15%; then add 1% photoinitiator I2959, mix thoro...

Embodiment 2

[0071] Example 2 Preparation of hydrogel (Gel-2: PEG-DA / PDA / PUE(L))

[0072] 1. Preparation method

[0073] Other conditions were the same as in Example 1, except that the concentration of the puerarin / polydopamine drug-loading solution was 5 mg / mL to obtain a hydrogel Gel-2: PEG-DA / PDA / PUE(L).

[0074] 2. Results

[0075] (1) For the actual picture, see image 3 As shown, the hydrogel is complete in shape, jelly-like, has good elasticity and good mechanical strength, and its elastic modulus is 0.64 ± 0.05 Mpa after testing.

[0076] (2) The scanning electron microscope picture is magnified 100 times to see Figure 4 , magnified 200 times to see Figure 5 It can be seen from the figure that the hydrogel has a porous three-dimensional network structure with relatively uniform pores.

Embodiment 3

[0077] Example 3 Preparation of hydrogel (Gel-1: PEG-DA, without puerarin)

[0078] 1. Preparation method

[0079] Other conditions were the same as in Example 1, the only difference being that no puerarin / polydopamine drug-loading solution was added to obtain hydrogel Gel-1: PEG-DA (without puerarin).

[0080] 2. Results

[0081] (1) For the actual picture, see image 3 As shown, the hydrogel is jelly-like, has good elasticity and good mechanical strength, and its elastic modulus is 0.44 ± 0.05 Mpa after testing.

[0082] (2) The scanning electron microscope picture is magnified 100 times to see Figure 4 , magnified 200 times to see Figure 5 It can be seen from the figure that the hydrogel presents a porous three-dimensional network structure.

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Abstract

The invention discloses antioxidant hydrogel for promoting wound healing as well as a preparation method and an application of the antioxidant hydrogel. The hydrogel contains a pattern drug, polydopamine nano particles, polyethyleneglycol diacrylate, a photoinitiator and water, wherein the sum of the polydopamine nano particles and polyethyleneglycol diacrylate in percentage by mass is 10%-23%, and water accounts for 75%-88% in percentage by mass. The hydrogel has the advantages of being good in biocompatibility and free of cytotoxicity; the hydrogel has a good moisturizing function and breathability, cannot result in wound dehydration, and has a good function of absorbing trauma secreta and good oxygen permeation property and controlled drug release capability, so that a hydrophobic drugcan be slowly released, slow release and controlled release effects are realized, blood concentration is kept in a stable and lasting effective range, further, the action time of the drug can be prolonged, and the hydrogel has functions of sufficiently inhibiting wound infection and effectively promoting wound healing, is high in safety and convenient to use and has broad application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to a hydrogel with antioxidant properties for promoting wound healing and its preparation method and application. Background technique [0002] The basic goal of treating skin wounds is to speed up the healing of wounds, prevent bacterial infection, reduce the pain caused by bleeding, inflammation, wound infection and even ulcers, prevent the negative impact of trauma on physiological functions, and make the wound as beautiful as possible after healing. The process of skin wound healing is divided into coagulation phase, inflammation phase, cell proliferation phase and tissue remodeling phase. It is a complex process involving many factors such as coagulation, inflammation, vascular remodeling, epithelial cell proliferation and migration, and tissue remodeling. The outcome of wound healing is also determined by the balance between these many factors. In this pr...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0019A61L26/0066A61L26/008A61L2300/216A61L2300/412A61L2300/624C08L71/02C08L79/04
Inventor 吴钧王彦张少瀚欧乾民顾志鹏
Owner SUN YAT SEN UNIV
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