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Hair development composition and preparation method of hair development composition lipid

A technology of composition and mass ratio, applied in the directions of drug combination, hair care, pharmaceutical formulation, etc., can solve the problems of unsuitability for heat-sensitive active ingredients, high temperature in the preparation process, residual harmful solvent, etc., and achieve no harmful solvent residue and preparation temperature. Low, good stability

Active Publication Date: 2018-11-02
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional preparation methods of liposomes include film dispersion method, pH gradient method, ultrasonic method, high-pressure homogenization method, etc., but these methods have disadvantages such as complicated operation, residual harmful solvents, high temperature in the preparation process, and are not suitable for the preparation of heat-sensitive active ingredients.

Method used

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  • Hair development composition and preparation method of hair development composition lipid
  • Hair development composition and preparation method of hair development composition lipid
  • Hair development composition and preparation method of hair development composition lipid

Examples

Experimental program
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Effect test

Embodiment 1

[0046] A preparation method of hair growth composition liposome, adopting the following steps:

[0047] Step 1: Weigh ligustrazine, panax notoginseng saponins, tanshinone Ⅱ A, thymol, adenosine, tripeptide-1 copper and fructose diphosphate tri Sodium, mixed as a hair growth composition;

[0048] Step 2: Weigh 6.4% hair growth composition, 9.6% phospholipid emulsifier, 4% phytosterol, 20% ethanol, 60% water by weight, and mix the hair growth composition, phospholipid emulsifier, phytosterol, ethanol, water After mixing, use an ultrasonic disperser at room temperature until no solid particles are visible to the naked eye to obtain a mixed dispersion;

[0049] Step 3: Add the mixed dispersion liquid obtained in step 2 into the supercritical reactor, the supercritical fluid used is carbon dioxide, inject the liquefied and pressurized carbon dioxide into the reactor, and keep the fluid temperature in the supercritical reactor at 25-35°C and the pressure at 10 -30MPa, carbon dioxi...

Embodiment 2

[0052] A preparation method of hair growth composition liposome, adopting the following steps:

[0053] Step 1: Weigh ligustrazine, panax notoginseng saponins, tanshinone Ⅱ A, thymol, adenosine, tripeptide-1 copper and fructose diphosphate tri Sodium, mixed as a hair growth composition;

[0054] Step 2: Weigh 6% hair growth composition, 15% phospholipid emulsifier, 8% phytosterol, 15% ethanol, 56% water by weight, and mix the hair growth composition, phospholipid emulsifier, phytosterol, ethanol, water After mixing, use an ultrasonic disperser at room temperature until no solid particles are visible to the naked eye to obtain a mixed dispersion;

[0055] Step 3: Add the mixed dispersion liquid obtained in step 2 into the supercritical reactor, the supercritical fluid used is carbon dioxide, inject the liquefied and pressurized carbon dioxide into the reactor, and keep the fluid temperature in the supercritical reactor at 25-35°C and the pressure at 10 -30MPa, carbon dioxide ...

Embodiment 3

[0058] A preparation method of hair growth composition liposome, adopting the following steps:

[0059] Step 1: Weigh ligustrazine, panax notoginseng saponins, tanshinone ⅡA, thymol, adenosine, tripeptide-1 copper and fructose diphosphate tri Sodium, mixed as a hair growth composition;

[0060] Step 2: Weigh 7% hair growth composition, 5% phospholipid emulsifier, 3% phytosterol, 30% ethanol, 55% water by weight, and mix the hair growth composition, phospholipid emulsifier, phytosterol, ethanol, water After mixing, use an ultrasonic disperser at room temperature until no solid particles are visible to the naked eye to obtain a mixed dispersion;

[0061] Step 3: Add the mixed dispersion liquid obtained in step 2 into the supercritical reactor, the supercritical fluid used is carbon dioxide, inject the liquefied and pressurized carbon dioxide into the reactor, and keep the fluid temperature in the supercritical reactor at 25-35°C and the pressure at 10 -30MPa, carbon dioxide ci...

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Abstract

The invention relates to hair development composition and a preparation method of hair development composition lipid. The hair development composition is characterized by being prepared from ligustrazine, panax notoginseng saponin, tanshinone IIA, thymol, adenosine, tripeptide-1 copper and fructose trisodium diphosphate in the mass ratio being (0.5-2):2:1.5:0.2:0.1:(0.05-0.2):0.5. The preparationmethod of hair development composition lipid comprises the steps as follows: A, weighing ligustrazine, panax notoginseng saponin, tanshinone IIA, thymol, adenosine, tripeptide-1 copper and fructose trisodium diphosphate to serve as the hair development composition; B, after the hair development composition is mixed with a phospholipid emulsifier, phytosterol, ethanol and water, ultrasonic assisteddispersion is performed, and a mixed dispersion liquid is obtained; C, the mixed dispersion liquid is added to a supercritical reactor to be circulated for 45-60 min with supercritical CO2 as a fluid; D, CO2 is quickly released to the reactor, the pressure is decreased to the normal pressure, and the hair development composition lipid is obtained. The hair development composition lipid has the benefits of good hair growth effect, good stability, low preparation temperature and no harmful solvent residues.

Description

technical field [0001] The invention relates to the technical field of cosmetic preparations, in particular to a hair growth composition and a method for preparing liposomes thereof. Background technique [0002] With the acceleration of the pace of society and the arrival of an aging society, hair loss has become a hot issue for consumers. Hair loss includes stress alopecia, androgenetic alopecia, alopecia areata, and female hair loss. The traditional theory of traditional Chinese medicine holds that "the liver controls hair growth". Therefore, traditional Chinese medicine prescriptions for hair growth and hair growth often treat hair loss by regulating the liver and nourishing blood. Commonly used medicinal materials include Chuanxiong, Danshen, Sanqi, and Baizhi. Modern biomedical science has discovered some different causes of hair loss through research, such as excessive androgen, strong oil secretion, and poor microcirculation. Treat hair loss. [0003] Based on the ...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/14A61K8/34A61K8/49A61K8/60A61K8/63A61K8/64A61P17/14A61Q7/00
CPCA61K8/14A61K8/347A61K8/494A61K8/60A61K8/63A61K8/64A61Q7/00A61K8/9789A61P17/14
Inventor 王晗宁蒋丽刚毕永贤黄洁芳刘红艳王晓
Owner PROYA COSMETICS
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