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Segmented copolymer nano-composite antibacterial material and preparation method and application thereof

A technology of block copolymers and antibacterial materials, which is applied in the field of block copolymer nanocomposite antibacterial materials and its preparation, can solve the problems of single function of antibacterial materials and uncontrollable synthesis of block copolymers, and achieve great flexibility and Inclusiveness, good cytocompatibility, effect of eliminating infection

Active Publication Date: 2018-10-23
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The primary purpose of the present invention is to overcome the shortcomings and deficiencies of the prior art, in order to solve technical problems such as the single function of the antibacterial material and the uncontrollable synthesis of block copolymers in the prior art, a kind of block copolymer nanocomposite antibacterial material is provided. Preparation

Method used

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  • Segmented copolymer nano-composite antibacterial material and preparation method and application thereof
  • Segmented copolymer nano-composite antibacterial material and preparation method and application thereof
  • Segmented copolymer nano-composite antibacterial material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] 2g PHBV (number average molecular weight 1.85×10 5 ) was dissolved in 20mL diglyme, heated to 140°C, N 2 Protection, add 4mL ethylene glycol, stir for 5min, add 0.02g dibutyltin dilaurate, stir for 5min, add dropwise 0.08g dibutyltin dilaurate, react for 7.5h, settle in cold ethanol, repeat 6 times, vacuum filter, vacuum Dry for 24 hours to obtain PHBV-diol. Take 0.0001mol PHBV-diol, dissolve in 15mL of anhydrous 1,2-dichloroethane, N 2 protection, warming up to 75°C, adding 0.0002mol IPDI, stirring for 5min, adding 0.02g dibutyltin dilaurate, stirring for 3h, cooling to room temperature, adding n-hexane and diethyl ether mixture (the volume ratio of n-hexane and diethyl ether is 1:1 ) sedimentation, washed repeatedly 3 times, filtered, and vacuum-dried at 40°C for 12 hours to obtain PHBV-2NCO. Dissolve 0.0001mol PHBV-2NCO in 15mL of anhydrous 1,2-dichloroethane, N 2 For protection, add 0.0002, 0.0003 and 0.0004mol PEG (weight average molecular weight 2000) respecti...

Embodiment 2

[0068] 2g PHBV (number average molecular weight 1.85×10 5 ) was dissolved in 20mL diglyme, heated to 140°C, N 2 For protection, add 4mL ethylene glycol, stir for 5min, add 0.02g dibutyltin dilaurate, stir for 5min, add 0.10g dibutyltin dilaurate, react for 9h, settle in cold methanol, repeat 3 times, vacuum filter, vacuum dry for 24h . Take 0.0001mol product and dissolve in 10mL anhydrous 1,2-dichloroethane, N 2 Protect, heat up to 75°C, add 0.0002mol IPDI, stir for 5min, add 0.02g dibutyltin dilaurate, stir for 5h, cool to room temperature, add n-hexane and petroleum ether mixture (the volume ratio of n-hexane and petroleum ether is 1 : 1) settling, washing repeatedly 6 times, filtering, vacuum drying at 40°C for 12h, to obtain PHBV-2NCO. Dissolve 0.0001mol PHBV-2NCO in 10mL of anhydrous 1,2-dichloroethane, N 2 For protection, add 0.0002mol PEG (weight average molecular weight 1000) respectively, heat up to 75°C, add 1wt% dibutyltin dilaurate, stir for 3h, cool to room te...

Embodiment 3

[0070] 2g PHBV (number average molecular weight 1.85×10 5 ) was dissolved in 10mL diglyme, heated to 140°C, N 2 Protection, add 3mL butanediol, stir for 5min, add 0.02g dibutyltin dilaurate, stir for 5min, add dropwise 0.08g dibutyltin dilaurate, react for 7.5h, settle in cold ethanol, repeat 6 times, acetone, water wash, vacuum Suction filtration and vacuum drying for 24 hours to obtain PHBV-diol. Take 0.0001mol PHBV-diol, dissolve in 15mL of anhydrous 1,2-dichloroethane, N 2 Protect, heat up to 75°C, add 0.00026molIPDI, stir for 5min, add 0.01g stannous octoate, stir for 3h, cool to room temperature, add n-hexane and petroleum ether mixture (n-hexane and petroleum ether volume ratio 1:1) to settle, Repeatedly washed 6 times, filtered, and vacuum dried at 40°C for 12 hours to obtain PHBV-2NCO. Dissolve 0.0001mol PHBV-2NCO in 15mL of anhydrous 1,2-dichloroethane, N 2 For protection, add 0.0002mol PEG (weight average molecular weight 2000) respectively, heat up to 75°C, add...

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Abstract

The invention provides a segmented copolymer nano-composite antibacterial material and a preparation method and application thereof. By the utilization of a coupling agent having 2 isocyanates with different activities, 3-hydroxybutanoic acid and 3-hydroxyvalerate copolyester (PHBV) are synthesized with polyethylene glycol (PEG) to obtain a PEG-PHBV-PEG amphiphilic triblock copolymer, which is used as a base material to be self-assembled with a nano-antibacterial agent to obtain the segmented copolymer nano-composite antibacterial material. Controllable synthesis and regulation of antibacterial properties of the segmented copolymer are realized by the method. Number-average molecular weight of the obtained segmented copolymer is between 0.35-13 thousand, and molecular weight distribution is relatively narrow. The segmented copolymer nano-composite antibacterial material has antibacterial and antimicrobial dual functions. Antibacterial effect and bactericidal effect are remarkably raised. A micelle coated nano-antibacterial agent is dispersed uniformly, is stable in a water phase, has good cytocompatibility and has a wide application prospect.

Description

technical field [0001] The invention belongs to the technical field of polymer materials and polymer-based composite materials, and in particular relates to a block copolymer nanocomposite antibacterial material and its preparation method and application. Background technique [0002] With the continuous expansion of the field of use of biomaterials, the incidence of biomaterial-related infections has increased year by year, which has become a major problem in modern medicine. High rates of infection can lead to tissue destruction, patient disability, and even death. Traditional antibiotic treatment often fails due to the low concentration at the infection site, and the appearance of bacterial biofilm and bacterial multidrug resistance on the surface of biomaterials further reduces the efficacy of antibiotics. Planktonic bacteria can attach to the surface in a few minutes, and react specifically with the material, making the reversible adhesion develop into irreversible adh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00C08G63/91C08K3/22A61K9/107A61K47/34
CPCA61K9/1075A61K47/34C08G63/912C08G81/00C08K3/22C08K2003/2296C08K2201/011
Inventor 柯渔谭绍早胡伟付鹏程范家琛刘财坤
Owner JINAN UNIVERSITY
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