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Method for extracting specnuezhenide

A technology for privetate glucoside and privet leaf, which is applied in the field of extracting privetate glucoside, and can solve the problems of difficulty in controlling the change of the solvent concentration of the extraction solution, uncontrollable change in the extraction temperature, long extraction time and the like.

Inactive Publication Date: 2018-10-23
NANJING ZELANG AGRI DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For extracting privetin, it has its limitations. For example, Soxhlet extraction is difficult to control the change of solvent concentration in the extract; leakage extraction cannot control the change of extraction temperature; and the heating reflux extraction method can control the extraction Solvent concentration, but only after 2 or 3 extractions can it be completely extracted, more extraction solvents are needed, and the extraction time is longer

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The raw material of privet leaf is dried, crushed, and passed through a 40-mesh sieve. The crushed raw material is placed in a microwave device, and 4 times of 60% ethanol solution is added, extracted for 45 minutes under the condition of a microwave power of 600W, filtered, and the filtrate Concentrate until there is no alcohol smell, filter the extract with a plate-and-frame machine with a filter cloth of 50µm in diameter, and the pressure is 0.1MPa. to 0.1MPa, the microfiltration permeate was concentrated to a relative density of 1, put on a neutral alumina column, eluted and purified with petroleum ether-ethyl acetate, the volume ratio of petroleum ether-ethyl acetate was 2:7, and condensed Vacuum-dried to obtain tervinetin.

Embodiment 2

[0015] The raw material of privet leaf is dried, crushed, and passed through a 40-mesh sieve. The crushed raw material is placed in a microwave device, and 6 times of 70% ethanol solution is added, extracted for 45 minutes under the condition of a microwave power of 900W, filtered, and the filtrate Concentrate until there is no alcohol smell, filter the extract with a plate and frame machine with a filter cloth pore size of 1.0µm, and the pressure is 1.0MPa. The pressure is 0.6MPa, the microfiltration permeate is concentrated to a relative density of 1, put on a neutral alumina column, and eluted with petroleum ether-ethyl acetate for purification, the volume ratio of petroleum ether-ethyl acetate is 2:7, shrink And vacuum-dried to obtain the privetin.

Embodiment 3

[0017] The raw material of privet leaf is dried, crushed, and passed through a 40-mesh sieve. The crushed raw material is placed in a microwave device, and 5 times of 60% ethanol solution is added, extracted for 45 minutes under the condition of a microwave power of 800W, filtered, and the filtrate Concentrate until there is no alcohol smell, filter the extract with a plate and frame machine with a filter cloth pore size of 1.0µm, the pressure is 0.1MPa, the liquid filtered by the plate and frame machine is microfiltered through a 0.02µm microfiltration device, and the microfiltration device is kept The pressure is 0.1MPa, the microfiltration permeate is concentrated to a relative density of 1, put on a neutral alumina column, and eluted with petroleum ether-ethyl acetate for purification, the volume ratio of petroleum ether-ethyl acetate is 2:7, shrink And vacuum-dried to obtain the privetin.

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PUM

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Abstract

The invention relates to a method for extracting specnuezhenide. The method comprises the following treatment steps: (1) with glossy privet leaves as a raw material, subjecting the glossy privet leaves to drying, smashing and sieving successively; (2) carrying out microwave extraction; (3) subjecting extract liquid obtained in the previous step to filtering with a plate-and-frame filter and purifying with a microfiltration device; and (3) subjecting microfiltration permeate obtained in the previous step to further purifying by a neutral alumina column, and carrying out concentration and dryingto obtain the specnuezhenide. The specnuezhenide obtained in the invention has the characteristics of high yield, simplified production process, short production cycle, high production efficiency, etc.

Description

Technical field: [0001] The invention relates to a method for extracting privetin, which belongs to the field of extraction and separation of effective components of Chinese herbal medicines. Background technique: [0002] Privet (scientific name: Ligustrum lucidum ) is an evergreen shrub or tree of the genus Ligustrum in the family Oleaceae, also known as ash tree and holly. kidney. It has the effect of lowering blood sugar and blood fat. [0003] At present, the research on Ligustrum lucidum mainly focuses on the pharmacological effects of total saponins, and there are few studies on the extraction methods of total saponins. The commonly used methods for saponin extraction are: conventional heating reflux extraction method, Soxhlet extraction method, percolation extraction method, etc. For extracting privetin, it has its limitations, such as Soxhlet extraction, it is difficult to control the change of the solvent concentration of the extract; leakage extraction cannot ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/04C07H1/08
CPCC07H17/04C07H1/08
Inventor 杨成东
Owner NANJING ZELANG AGRI DEV
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