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Embolism agent as well as preparation method and application thereof

An embolic agent and solvent technology, applied in the field of medicine, can solve problems such as low detection effect, unfavorable diagnosis and differential diagnosis, etc., and achieve the effects of hindering nutrient delivery and absorption, uniform particle size, and narrow central particle size distribution.

Active Publication Date: 2018-10-19
SOUTH CHINA NORMAL UNIVERSITY +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, MRI is not sensitive to calcification, calculus and cortical bone, which leads to low detection effect in some parts, which is not conducive to diagnosis and differential diagnosis. Therefore, further improving the inspection effect of MRI is positive for the accurate diagnosis of tumors. the meaning of

Method used

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  • Embolism agent as well as preparation method and application thereof
  • Embolism agent as well as preparation method and application thereof
  • Embolism agent as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0045] 2-Mercaptoethanol, carbon disulfide and dibromo-p-xylene were reacted in acetone at a molar ratio of 2:6:1 to synthesize a thiocarbonate chain transfer agent with a symmetrical structure. Then, acrylamide and acrylonitrile were used as raw materials, dissolved in DMF solution at a mass ratio of 55:45, and a chain transfer agent was added (the molar weight was 1 / 100 of the acrylonitrile content), and random copolymerization was prepared by RAFT free radical polymerization UCST polymer material P(AAm-co-AN).

[0046] Take P(AAm-co-AN) and dissolve it with DMF organic solvent to form an organic solution with a concentration of 5wt%. According to the molar weight of polymer P(AAm-co-AN), press P(AAm-co-AN): average Trimellitic acid: dicyclohexylcarbodiimide (DCC): 4-dimethylaminopyridine (DMAP) molar ratio is 1:7:20:2 Weigh trimellitic acid, dicyclohexylcarbodiimide (DCC ) and 4-dimethylaminopyridine (DMAP) were dissolved in the above organic solution to prepare a disperse...

Embodiment 2

[0049] Take P(AAm-co-AN) and dissolve it with DMF organic solvent to form an organic solution with a concentration of 5wt%. According to the molar weight of polymer P(AAm-co-AN), press P(AAm-co-AN): average Trimellitic acid: dicyclohexylcarbodiimide (DCC): 4-dimethylaminopyridine (DMAP) molar ratio is 1:7:20:2 Weigh trimellitic acid, dicyclohexylcarbodiimide (DCC ) and 4-dimethylaminopyridine (DMAP) were dissolved in the above organic solution to prepare a dispersed phase. Dissolve cetyl polyethylene glycol / polypropylene glycol-10 / 1 dimethylsiloxane (ABIL EM90) in mineral oil at a mass ratio of 15 wt% to form a mineral oil solution containing an emulsifier to obtain a mobile phase. Add the dispersed phase dropwise into the mobile phase according to the mass ratio of the dispersed phase: the mobile phase is 1:25 and vortex at a high speed. The vortexed emulsion is subjected to probe ultrasonication through an ultrasonic breaker to generate a spherical shape with a uniform diame...

Embodiment 3

[0052] Take P(AAm-co-AN) and dissolve it with DMF organic solvent to form an organic solution with a concentration of 5wt%, and measure 1 mg / mL of polyethyleneimine-modified Fe at a volume ratio of 5:1 3 o 4 The aqueous solution of nanoparticles and the DMF solution of P(AAm-co-AN) are mixed uniformly to form a solution. According to the molar weight of the polymer P(AAm-co-AN), according to P(AAm-co-AN): Trimellitic acid: Dicyclohexylcarbodiimide (DCC): 4-dimethylaminopyridine (DMAP) molar ratio is 1:7:20:2 Weigh trimesic acid, dicyclohexylcarbodiimide (DCC) and 4- Dimethylaminopyridine (DMAP) was dissolved in the above solution to prepare the dispersed phase. Dissolve cetyl polyethylene glycol / polypropylene glycol-10 / 1 dimethylsiloxane (ABIL EM90) in mineral oil at a mass ratio of 15 wt% to form a mineral oil solution containing an emulsifier to obtain a mobile phase. Add the dispersed phase dropwise into the mobile phase according to the mass ratio of the dispersed phase:...

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Abstract

The invention discloses an embolism agent as well as a preparation method and application thereof. The embolism agent is generated by reaction matter raw materials by crosslinking reaction, and the reaction matter raw materials comprise a dispersing phase and a flowing phase; the dispersing phase is prepared from poly(acrylamide-co-acrylonitrile), a crosslinking agent, a condensing agent and a solvent; the crosslinking agent at least comprises two carboxyl groups; the flowing phase is prepared from an emulsifier and mineral oil. The embolism agent has the advantages that the preparation technology is simple; the prepared embolism material can block the nutrition conveying and absorbing of tumors; after the prepared embolism material is combined with a magnetic resonance imaging matter anda fluorescent development reagent, the prepared embolism material can be expanded to realize fixed-point release and developing at the tumor areas; the better application prospect is realized in the aspect of tumor treatment.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a embolic agent and its preparation method and application. Background technique [0002] Smart material or smart material is a new material that can sense changes in the surrounding environment and respond to changes in the environment. Stimulus-responsive materials are a kind of smart materials. Under the stimulation of environmental factors (including light, temperature, pH, ionic strength, electric field, magnetic field and specific molecules, etc.), some of their physical and chemical properties (including relative State, shape, surface energy, reaction rate, permeability, etc.) undergo corresponding changes in materials. Hydrogel is a kind of polymer that is hydrophilic but insoluble in water and has a cross-linked three-dimensional network structure. Conversion, adsorption separation, good biocompatibility and other outstanding performance. The combination of hydrogels and smart...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/06A61L24/00
CPCA61L24/001A61L24/0031A61L24/06A61L2400/06C08L33/26
Inventor 李皓甘盛龙陈龙斌周国富
Owner SOUTH CHINA NORMAL UNIVERSITY
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