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Double-bionic polymer and preparation method and application thereof

A technology of polymer and polymerization reaction, applied in the direction of coating, etc., can solve problems such as shedding, achieve simplified conditions and processes, excellent adhesion performance, and good anti-biological pollution effects

Inactive Publication Date: 2018-10-16
XIAN UNVERSITY OF ARTS & SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] For this reason, the technical problem to be solved by the present invention is to provide a double biomimetic polymer to solve the problem that the coating is prone to dissolve, degrade, or even the problem of shedding;

Method used

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  • Double-bionic polymer and preparation method and application thereof
  • Double-bionic polymer and preparation method and application thereof
  • Double-bionic polymer and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation method of double biomimetic polymer described in this embodiment comprises the following steps:

[0035] (1) Accurately weigh 8 mmol of 2-methacryloyloxyethyl phosphorylcholine and 2 mmol of pentafluorophenyl methacrylate, dissolve and mix them evenly in a mixed solvent of ethanol and tetrahydrofuran (volume ratio 4:1), and dissolve 0.1 mmol of Azobisisobutyronitrile is dissolved in tetrahydrofuran to obtain an initiator solution, and in N 2 Protection, under the condition of stirring at 70°C, add the mixed solution of monomers to the three-necked flask, preheat for 30 minutes, add the initiator solution to continue the reaction for 24 hours, after the reaction is completed, concentrate the reaction solution, and use a molecular weight cut-off of 6000-8000D The dialysis bag was used for dialysis; finally, the dialysis sample was freeze-dried at -50°C to obtain the phosphorylcholine polymer containing pentafluorophenyl; the nuclear magnetic test results s...

Embodiment 2

[0039] The preparation method of double biomimetic polymer described in this embodiment comprises the following steps:

[0040] (1) Weigh 7 mmol of 2-methacryloyloxyethyl phosphorylcholine and 3 mmol of pentafluorophenyl methacrylate, dissolve and mix them evenly in a mixed solvent of methanol and tetrahydrofuran (volume ratio 4:1), and mix 0.1 mmol of Azodiisobutyronitrile is dissolved in tetrahydrofuran to obtain an initiator solution, and in N 2 Protection, under the condition of stirring at 60°C, add the mixed solution of monomers into the three-necked flask, preheat for 30 minutes, add the initiator solution to continue the reaction for 24 hours, after the reaction is completed, concentrate the reaction solution, and use a dialyzer with a molecular weight cut-off of 6000-8000D bag dialysis; finally, freeze-dry the dialyzed sample at -50°C to obtain a phosphorylcholine polymer containing pentafluorophenyl; NMR test results show that the molar content of pentafluorophenyl i...

Embodiment 3

[0043] The preparation method of double biomimetic polymer described in this embodiment comprises the following steps:

[0044] (1) Accurately weigh 6mmol 2-methacryloyloxyethylphosphorylcholine and 4mmol pentafluorophenyl methacrylate, dissolve and mix evenly in a mixed solvent of ethanol and tetrahydrofuran (volume ratio 4:1), and mix 0.1 Mmol azobisisobutyronitrile is dissolved in tetrahydrofuran to obtain initiator solution, in N 2 Protection, under the condition of stirring at 80°C, add the mixed solution of monomers into the three-necked flask, preheat for 30 minutes, add the initiator solution and continue the reaction for 24 hours. bag dialysis; finally, freeze-dry the dialyzed sample at -50°C to obtain a phosphorylcholine polymer containing pentafluorophenyl; NMR test results show that the molar content of pentafluorophenyl in the polymer About 38%;

[0045] (2) Get 0.5g of the phosphorylcholine polymer containing pentafluorophenyl obtained in the above-mentioned st...

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Abstract

The invention belongs to the technical field of material surface science and biomedical macromolecular materials, particularly relates to a double-bionic polymer which is synthesized on the basis of grafting reaction of pentafluorophenyl, and further discloses a preparation method and application thereof. The double-bionic polymer is prepared from the following raw materials of a vinyl monomer containing phosphorylcholine groups and a vinyl monomer containing pentafluorophenyl through free radical polymerizing reaction, so as to obtain the phosphorylcholine polymer containing the pentafluorophenyl; the clam-like attachment protein dopamine and the phosphorylcholine polymer containing the pentafluorophenyl are combined. The double-bionic polymer has the advantages that the o-diphenol hydroxyl can reach the adhering function of the clam-like attachment protein dopamine, the excellent adhering property on the material surface is realized by the water-soluble polymer, the phosphorylcholinehas the anti-pollution property of a cell external membrane-simulating structure, and the good anti-biological pollution property is obtained; the double-bionic property is realized, and the broad application prospect is realized in the field of modification of material surfaces.

Description

technical field [0001] The invention belongs to the technical fields of material surface science and biomedical polymer materials, specifically relates to a double biomimetic polymer synthesized based on pentafluorophenyl grafting reaction, and further discloses its preparation method and application. Background technique [0002] Biocompatibility refers to a concept of various biological, physical, chemical and other reactions produced after the interaction between materials and organisms. Generally speaking, it is the degree of compatibility with the human body after the material is implanted into the human body, that is to say, whether it will cause toxic effects on human tissues. Under normal circumstances, when general materials are used in vivo, non-specific adsorption proteins are easily produced, which activate complement molecules and the immune system, thereby causing blood coagulation, immune and inflammatory reactions, resulting in significantly reduced performan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F230/02C08F220/22C08F8/32C09D151/00
CPCC08F8/32C08F220/22C08F230/02C09D151/003
Inventor 李树娜贾园杜威刘振朱刚方振华
Owner XIAN UNVERSITY OF ARTS & SCI
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