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Method for preparing medicine for treating hypertension from peony root, herba dendrobii officmalis and irbesartan

A technology of Dendrobium officinale and high blood pressure, applied in the field of drug preparation, can solve problems such as the compatibility and use of traditional Chinese medicines, and achieve the effects of improving the quick-acting blood pressure reducing effect, improving the quick effect, and improving the long-acting blood pressure reducing effect.

Active Publication Date: 2018-10-16
HANGZHOU DANHE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the use of traditional Chinese medicine, these two traditional Chinese medicines are rarely used in combination.

Method used

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  • Method for preparing medicine for treating hypertension from peony root, herba dendrobii officmalis and irbesartan
  • Method for preparing medicine for treating hypertension from peony root, herba dendrobii officmalis and irbesartan
  • Method for preparing medicine for treating hypertension from peony root, herba dendrobii officmalis and irbesartan

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Proportions by weight: 800 parts of Dendrobium officinale, 600 parts of Radix Paeoniae Alba, 7.5 parts of irbesartan, 400 g of Dendrobium officinale, 300 g of Radix Paeoniae Alba, and 3.75 g of irbesartan conforming to the 2015 edition of "Chinese Pharmacopoeia".

[0038] Grind Radix Paeoniae Alba into powder, add 70% ethanol of 7 times the total crude drug amount, and extract under reflux for 1 hour, extract twice, and extract the residue with water after alcohol extraction;

[0039] The residue after alcohol extraction of Paeoniae Alba was extracted twice with water: the first water extraction: add 10 times the amount of crude drug in water, extract at 100°C for 1 hour; the second water extraction: add 10 times the total amount of crude drug in water, Extract at 100°C for 1 hour. The aqueous extracts were combined and concentrated. Combine Paeoniae Alba Alcoholic Extract and Water Extract.

[0040] Grind Dendrobium officinale into powder, add Dendrobium officinale p...

Embodiment 2

[0042] Proportions by weight: 800 parts of Dendrobium officinale, 200 parts of Radix Paeoniae Alba, 7.5 parts of irbesartan, 400 g of Dendrobium officinale, 100 g of Radix Paeoniae Alba, and 3.75 g of irbesartan conforming to the 2015 edition of "Chinese Pharmacopoeia".

[0043] Grind Radix Paeoniae Alba into powder, add 70% ethanol of 7 times the total crude drug amount, and extract under reflux for 1 hour, extract twice, and extract the residue with water after alcohol extraction;

[0044] The residue after alcohol extraction of Paeoniae Alba was extracted twice with water: the first water extraction: add 10 times the amount of crude drug in water, extract at 100°C for 1 hour; the second water extraction: add 10 times the total amount of crude drug in water, Extract at 100°C for 1 hour. The aqueous extracts were combined and concentrated. Combine Paeoniae Alba Alcoholic Extract and Water Extract.

[0045] Grind Dendrobium officinale into powder, add Dendrobium officinale p...

Embodiment 3

[0047] Proportions by weight: 800 parts of Dendrobium officinale, 3200 parts of Radix Paeoniae Alba, 7.5 parts of irbesartan, 100 g of Dendrobium officinale, 400 g of Radix Paeoniae Alba, and 0.9375 g of irbesartan conforming to the 2015 edition of "Chinese Pharmacopoeia".

[0048] Grind Radix Paeoniae Alba into powder, add 70% ethanol of 7 times the total crude drug amount, and extract under reflux for 1 hour, extract twice, and extract the residue with water after alcohol extraction;

[0049] The residue after alcohol extraction of Paeoniae Alba was extracted twice with water: the first water extraction: add 10 times the amount of crude drug in water, extract at 100°C for 1 hour; the second water extraction: add 10 times the total amount of crude drug in water, Extract at 100°C for 1 hour. The aqueous extracts were combined and concentrated. Combine Paeoniae Alba Alcoholic Extract and Water Extract.

[0050] Grind Dendrobium officinale into powder, add Dendrobium officinal...

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Abstract

The invention relates to the field of medicine preparation technologies, and aims to provide a method for preparing a medicine for treating hypertension from peony root, herba dendrobii officmalis andirbesartan. The method comprises the steps that after the peony root is subjected to levigation, alcohol extraction is conducted, residues after alcohol extraction are subjected to water extraction treatment, and concentrated extraction solutions are combined; the herba dendrobii officmalis is subjected to levigation, herba dendrobii officmalis powder and irbesartan powder are added into the combined extraction solution for even mixing; an accessory is added to prepare the medicine for treating hypertension. In the method, the curative effect of an alcohol and water extraction method extractof the peony root and the herba dendrobii officmalis powder on treating hypertension is outstanding, compared with conventional water extraction, the alcohol and water extraction method of the peony root has the advantages that component loss is reduced, thus the effectiveness is improved, and full use of the peony root can be promoted; through compatibility of the herba dendrobii officmalis withthe peony root, not only can the efficacy of decreasing the blood pressure be achieved, but also the good mid-term and long-term stable blood pressure can be obtained, and the physique with equilibrium between yin and yang is adjusted and recovered; by means of the traditional Chinese medicine and western medicine combined composition, under the condition of a small western medicine dosage, the curative effect close to that of the conventional dosage of a western hypotensive medicine can be achieved, and thus the application prospects are greatly expanded.

Description

technical field [0001] The invention relates to medicine preparation technology, in particular to a method and application of preparing medicine for treating hypertension with white peony root, dendrobium officinale and irbesartan. Background technique [0002] Hypertension is a common high incidence clinically, which has serious harm to the heart, brain, kidney and other important organs. Western medicine treatment of hypertension still lacks the medicine for adjusting body constitution and can adjust blood pressure (depressor). The antihypertensive treatment of modern medicine is all symptomatic treatment. Currently commonly used antihypertensive drugs include calcium channel blockers (CCBs), angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), diuretics, and β-blockers. , still can not completely prevent the progression of hypertension and its secondary lesions. Most hypertensive patients need two or more antihypertensive drugs to ...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61P9/12A61K31/4184
CPCA61K31/4184A61K36/65A61K36/71A61K36/8984A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61P9/12A61K2300/00
Inventor 吴悦吴人照
Owner HANGZHOU DANHE PHARM CO LTD
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