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Two-factor sustained-release system based on poc and mesoporous nanospheres

A microsphere and mesoporous technology, applied in the field of nanotechnology and biomedicine, can solve the problems of difficult drug dispersion, affecting sample release rate, sample inhomogeneity, etc.

Active Publication Date: 2021-10-29
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional drug loading process is to directly deposit the drug on the carrier under pressure and mechanically mix the carrier and the drug. This method is usually difficult to disperse the drug evenly on the carrier matrix, making the sample inhomogeneous, which will directly affect the sample. release rate

Method used

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  • Two-factor sustained-release system based on poc and mesoporous nanospheres
  • Two-factor sustained-release system based on poc and mesoporous nanospheres
  • Two-factor sustained-release system based on poc and mesoporous nanospheres

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preparation example Construction

[0067] In another preferred embodiment, the preparation method of the pharmaceutical composite film of the present invention includes the following steps:

[0068] (1) Anhydrous ethanol, deionized water, and ammonia were mixed with 10-20: 5-10: 1, and stirred at 25-40 ° C (preferably 30 ° C) for 30 to 50 min. Ethyl lysate was added to the above system, and stirred for 40 to 60 min. The uniform mixture of orthosate esters and silane coupling agents in advance was added, stirred by stirring 80 to 100 min, and dispersed from 0.5-2 mol / ml (preferably 1.0 mol / ml) Na after centrifugation. 2 CO 3 In the solution, the dispersed sol was then stirred at 60-90 ° C (preferably 80 ° C), washed 3 times in centrifugation, freeze drying to obtain a hollow diaphragm SiO 2 Microspheres.

[0069] (2) Take an appropriate amount of hollow mesoporous SiO obtained in step (1) 2 The microspheres were dispersed in ethanol solutions of hydrophobic drugs, 40 to 60 ° C, stirring 2 to 4 days, freeze dryin...

Embodiment 1

[0080] Hollow mesh SiO 2 Microsphere preparation

[0081] 65 ml of anhydrous ethanol, 10 ml of deionized water, 2.75 ml ammonia were mixed, and stirred at 30 ° C for 30 min. 6 ml of orthosilicate was added to the above system, stirred for 40 min. 5 ml of 5 ml of 5 ml of 5 ml of 5 ml of 5 ml of 5 ml of 5 ml of 3.5 ml of 3-aminopropyltrimethoxysilane was added, stirred for 80 min, separated from centrifugation, washed once. After centrifugation of the product, stirred from 200 ml of 1.0 mol / L of NA 2 CO 3 In the solution, the dispersed sol was stirred at 80 ° C for 60 min, and the deionized water was washed 3 times, and the addition of the product was obtained. Transmission electron microscopy figure 1 C, the size is one, and the microspheres are uniform, no serious agglomeration.

[0082] Nitrogen adsorption desorption experiment figure 2 The curve has a stranded ring phenomenon, indicating the hollow SIO 2 There is a mesh structure in the microsphere. According to the calculatio...

Embodiment 2

[0085] Hollow mesh SiO 2 Microsphere preparation

[0086] In the same embodiment, the step in the step is Na 2 CO 3 The concentration of the solution was changed from 1.0 mol / L to 0.6 mol / L, and the other conditions were constant, and the mesh SiO was obtained. 2 Microspheres, transmission electron microscopy figure 1 A, the size is one, and the microspheres are uniform, no serious agglomeration.

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Abstract

The invention relates to a dual-factor slow-release system based on POC and mesoporous nanometer microspheres, which is a composite membrane, specifically a polycitrate-1,8 octanediol ester membrane loaded with mesoporous silica microspheres. The invention also provides a preparation method of the film and a drug-carrying system using the film as a release carrier. The composite membrane of the present invention has high drug-loading rate of hollow mesoporous microspheres, POC can be degraded, and the double slow-release system formed by the two can improve the persistence of drug effect, and can be used in drugs, dyes, cosmetics, sensitive reagents such as growth factors, etc. It has important application value in the controllable transport and release.

Description

Technical field [0001] The present invention relates to the field of nanotechnology and biomedical, and specific to a POC / Sio 2 Preparation of the composite film is suitable for controlled transportation and release of drugs, dyes, cosmetics, sensitive reagents such as growth factors. Background technique [0002] In the field of drug treatment, especially for oral drugs, the drug carrier material can help the drug release to the effective blood concentration range, and can maintain the blood concentration within this range for a long time to reduce the number of administrations, Reduce patient pain. In order to adapt to the actual application needs, the drug carrier material is also required to have a high drug loading and an appropriately slow or even stable release rate. [0003] Ibuprofen (IBU) is an anti-inflammatory analgesic drug. Since it is suitable for drug loading, it is often used as typical drugs in pharmaceutical release experiments for drug loading in the aqueous...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L67/00C08K9/12C08K9/06C08K7/26C08J5/18C08G63/02A61K9/70A61K47/02A61K31/192A61K8/85A61K8/25A61K8/02A61Q19/00
CPCA61K8/0204A61K8/25A61K8/85A61K9/7007A61K31/192A61K47/02A61K47/34A61Q19/00C08G63/02C08J5/18C08J2367/00C08K7/26C08K9/06C08K9/12C08K2201/003C08K2201/006C08L2201/06C08L2203/16C08L67/00
Inventor 刘昌胜陈芳萍宋之言葛彩彩毛丽杰
Owner EAST CHINA UNIV OF SCI & TECH
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