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Two-factor slow-release system based on POC and mesoporous nanospheres

A microsphere and drug-loading system technology, applied in the field of nanotechnology and biomedicine, can solve problems such as difficult drug dispersion, sample inhomogeneity, and affecting sample release rate, and achieve the effect of improving durability and high drug loading rate

Active Publication Date: 2018-10-09
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional drug loading process is to directly deposit the drug on the carrier under pressure and mechanically mix the carrier and the drug. This method is usually difficult to disperse the drug evenly on the carrier matrix, making the sample inhomogeneous, which will directly affect the sample. release rate

Method used

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  • Two-factor slow-release system based on POC and mesoporous nanospheres
  • Two-factor slow-release system based on POC and mesoporous nanospheres
  • Two-factor slow-release system based on POC and mesoporous nanospheres

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preparation example Construction

[0067] In another preferred example, the preparation method of the drug-loaded composite membrane of the present invention includes the following steps:

[0068] (1) Mix absolute ethanol, deionized water, and ammonia water in a molar ratio of 10-20:5-10:1, and stir at 25-40°C (preferably 30°C) for 30-50 minutes. Quickly add ethyl orthosilicate to the above system, and stir for 40-60 minutes. Add the homogeneous mixture of ethyl orthosilicate and silane coupling agent prepared in advance, stir for 80-100 minutes, and disperse in 0.5-2mol / mL (preferably 1.0mol / mL) Na 2 CO 3 solution, then vigorously stir the dispersed sol at 60-90°C (preferably 80°C), centrifuge and wash 3 times, freeze-dry to obtain hollow mesoporous SiO 2 Microspheres.

[0069] (2) Take an appropriate amount of hollow mesoporous SiO prepared in step (1) 2 The microspheres are dispersed in the ethanol solution of the hydrophobic drug, stirred at 40-60° C. for 2-4 days, and freeze-dried to obtain the drug-lo...

Embodiment 1

[0080] Hollow Mesoporous SiO 2 Preparation of microspheres

[0081] Mix 65mL absolute ethanol, 10mL deionized water, and 2.75mL ammonia water, and stir at 30°C for 30min. Quickly add 6 mL of ethyl orthosilicate to the above system, and stir for 40 min. Add a homogeneous mixture of 5 mL ethyl orthosilicate and 2.5 mL 3-aminopropyltrimethoxysilane that has been stirred for 5-6 min, stir for 80 min, centrifuge, and wash once with water. After centrifuging the product, stir and disperse it in 200mL of 1.0mol / L Na 2 CO 3 In the solution, the dispersed sol was vigorously stirred at 80° C. for 60 min, washed with deionized water three times, and freeze-dried to obtain the product. The results of transmission electron microscopy are shown in figure 1 c, the size is uniform, and the microspheres are evenly dispersed without serious agglomeration.

[0082] Nitrogen adsorption and desorption experiment results are shown in figure 2 , the curve has a stagnant loop phenomenon, indi...

Embodiment 2

[0085] Hollow Mesoporous SiO 2 Preparation of microspheres

[0086] With embodiment 1, Na in the step 2 CO 3 The concentration of the solution was changed from the original 1.0mol / L to 0.6mol / L, and other conditions remained unchanged, and the mesoporous SiO 2 Microspheres, transmission electron microscope results see figure 1 a, The size is uniform, and the microspheres are evenly dispersed without serious agglomeration.

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Abstract

The invention relates to a two-factor slow-release system based on POC and mesoporous nanospheres. The two-factor slow-release system based on the POC and the mesoporous nanospheres is a composite film, specifically a polycitric acid-1,8 octanediol ester film loaded with mesoporous silicon dioxide microspheres. The invention further provides a preparation method of the film and a medicine-loadingsystem using the film as a release carrier. In the composite film, the hollow mesoporous microspheres have a high medicine-loading rate and the POC can be degraded, and the two-factor slow-release system formed by the two can improve the durability of the medicinal efficacy and has an important application value in controllable transportation and release of medicines, dyes, cosmetics, and sensitive reagents such as a growth factor and the like.

Description

technical field [0001] The invention relates to the field of nanotechnology and the field of biomedicine, in particular to a POC / SiO 2 The preparation of composite membranes is suitable for the controlled transport and release of drugs, dyes, cosmetics, sensitive agents such as growth factors, etc. Background technique [0002] In the field of drug therapy, especially in the research of oral drugs, the drug carrier material can help the drug release to the effective blood concentration range, and can maintain the blood concentration in this range for a long time, so as to reduce the number of administration, Reduce patient pain. In order to meet the needs of practical applications, drug carrier materials are also required to have a higher drug loading and a moderately slow or even stable release rate. [0003] Ibuprofen (IBU) is an anti-inflammatory analgesic drug. Due to its low solubility in aqueous solution and small molecular weight for drug loading, it is often used ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/00C08K9/12C08K9/06C08K7/26C08J5/18C08G63/02A61K9/70A61K47/02A61K31/192A61K8/85A61K8/25A61K8/02A61Q19/00
CPCA61K8/0204A61K8/25A61K8/85A61K9/7007A61K31/192A61K47/02A61K47/34A61Q19/00C08G63/02C08J5/18C08J2367/00C08K7/26C08K9/06C08K9/12C08K2201/003C08K2201/006C08L2201/06C08L2203/16C08L67/00
Inventor 刘昌胜陈芳萍宋之言葛彩彩毛丽杰
Owner EAST CHINA UNIV OF SCI & TECH
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