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Composition for immunity induction promotion and vaccine pharmaceutical composition

A technology of immune induction and composition, which is applied in the field of immune induction and promotion composition and vaccine pharmaceutical composition, and can solve problems such as difficulty in administration technology, burden on patients, and unclear effective promotion

Inactive Publication Date: 2018-09-28
NITTO DENKO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, injections have the following problems from the viewpoint of QOL of patients: Pain, fear, injection marks, and subsequent scars, etc. burden the patient's body and mind; the burden of
In addition, there are still problems such as injections that can only be performed by medical staff, difficult administration techniques for intradermal injections with high immune effects, risks of needlestick infection accidents among medical staff, and medical waste that requires special disposal such as injection needles. substances, etc., so it may not be the most suitable route of administration
However, Patent Document 4 only describes the evaluation for the induction of cellular immunity, and it is not clear about the technology for effectively promoting humoral immunity that induces antibody production.

Method used

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  • Composition for immunity induction promotion and vaccine pharmaceutical composition
  • Composition for immunity induction promotion and vaccine pharmaceutical composition
  • Composition for immunity induction promotion and vaccine pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～14、 comparative example 1～2

[0203] (Preparation of Cream for Transdermal Administration)

[0204] A cream for transdermal administration having the composition of Table 1 below was prepared.

[0205] Specifically, 5% by mass of the antigen shown below, 3% by mass of the first immunity-inducing promoter, 1% by mass of the second immune-inducing promoter, and two 15% by mass of methyl sulfoxide (DMSO), and a base (base cream) was added thereto to make the total amount 100% by mass, and mixed to obtain a cream for transdermal administration. The base cream used was prepared by compounding and kneading materials according to the compositions shown in Table 8. White petrolatum, sorbitan monostearate, isostearic acid, benzyl alcohol, stearyl alcohol, Tween 60, concentrated glycerin, and dimethyl sulfoxide (DMSO) were purchased from Wako Pure Chemical Industries, Ltd. Cetyl alcohol was purchased from Tokyo Chemical Industry Co., Ltd.

[0206] Prepare PET film / PET non-woven fabric laminate (area 0.7cm 2 ) A ...

Embodiment 15～26、 comparative example 3～8

[0235] (Preparation of adhesive tape for transdermal administration)

[0236] Tape preparations for transdermal administration having the compositions in Table 2 below were prepared. Specifically, the antigen, the first immunity induction promoter, and the second immunity induction promoter were compounded in the compounding amounts shown in the following Table 2, and the components after drying with an organic solvent and the adhesive base The adhesive base shown in the following Table 2 and the organic solvent (ethyl acetate) were mix|blended and mixed so that the total may be 100 mass %, and the adhesive solution was prepared. The obtained pressure-sensitive adhesive solution was spread on a release liner so that the thickness after drying was about 80 μm, and the organic solvent was removed by drying to form a pressure-sensitive adhesive layer. As the release liner, a liner made of polyethylene terephthalate (PET) (thickness: 75 μm) subjected to a silicone release treatme...

Embodiment 27～42、 comparative example 9～10

[0245] (Preparation of Liquid Preparations for Transmucosal Administration)

[0246] Liquid preparations for transmucosal administration (nasal administration or sublingual administration) having the compositions in Tables 3 and 4 below were prepared. Specifically, the antigen (ovalbumin (OVA)) and the first immunity induction promoter were compounded in the compounding amounts shown in the following Tables 3 and 4, physiological saline was added thereto, and 10 μL was prepared for nasal administration. Or in the case of sublingual administration, prepare 30 μL and mix to obtain a liquid preparation for transmucosal administration (nasal administration or sublingual administration).

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Abstract

The purpose of the present invention is to provide a composition for immunity induction promotion that can be universally used for induction of cellular immunity and / or humoral immunity against a variety of antigens and can exhibit a strong cellular immunity-inducing effect and / or humoral immunity-inducing effect. The composition for immunity induction promotion is characterized in comprising a first immunity induction promotion agent, which is an intracellular ion concentration agonist that affects the ion channel or ion pump.

Description

technical field [0001] The present invention relates to an immunity-inducing and promoting composition and a vaccine pharmaceutical composition, and particularly relates to an immunity-inducing and promoting composition and a vaccine pharmaceutical composition comprising a drug that acts on an ion channel or an ion pump to control intracellular ion concentration. Background technique [0002] Vaccines that are generally and widely used are substances that attenuate or detoxify pathogens such as microorganisms or viruses, or a part thereof, and induce immunity by administering to living organisms. As the dosage form of vaccine preparations, the currently commercialized ones are basically injections. [0003] Induction of immunity by vaccine administration is usually performed by injection such as subcutaneous or intradermal injection, intramuscular injection, or the like. In particular, the size of microorganisms, viruses prevents them from invading the skin, so vaccines nee...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/39A61K39/00
CPCA61K39/00A61K39/39A61P37/00A61K45/06A61K2300/00A61K31/704A61K31/58A61K31/7048A61K9/0019A61K2039/5154
Inventor 浅利大介宍户卓矢松下恭平堀光彦
Owner NITTO DENKO CORP
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