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Core-shell type sericin material gold nano rod and preparation method and applications thereof

A gold nanorod and core-shell type technology, which is applied in the field of core-shell sericin material gold nanorods and its preparation, can solve the problems of poor stability of gold nanorods, limit the application of gold nanorods, etc., achieve short time and reduce cytotoxicity , the effect of increasing cellular uptake

Inactive Publication Date: 2018-09-18
ZHEJIANG UNIV
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Problems solved by technology

However, the surfactant cetyltrimethylammonium bromide (CTAB) introduced during the synthesis of gold nanorods is cytotoxic, and the gold nanorods made of it as a surfactant have poor stability in aqueous solution, which limits Applications of gold nanorods

Method used

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  • Core-shell type sericin material gold nano rod and preparation method and applications thereof
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  • Core-shell type sericin material gold nano rod and preparation method and applications thereof

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preparation example Construction

[0033] The invention discloses a method for preparing a core-shell type sericin material gold nanorod, and the specific preparation steps are as follows:

[0034] 1), using seed-mediated synthesis or other methods to synthesize gold nanorods using CTAB as a surfactant;

[0035] 2), extracting a sericin solution with a concentration above 0.1%;

[0036] 3), the gold nanorods were centrifuged 1-2 times to reduce the concentration of CTAB;

[0037] 4) Add an equal volume of about 0.1% sericin solution;

[0038] 5) After ultrasonication for 20 minutes, centrifuge to remove excess sericin;

[0039] 6) Submerge and fix the precipitate in more than 80% methanol for 20 minutes, and centrifuge twice to remove methanol.

[0040] 7), repeating steps 3)-6) to obtain gold nanorod sericin material coated layer by layer, the thickness of the sericin layer increases with the increase of the number of coating layers.

[0041] The invention also discloses a sericin material gold nanorod use...

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Abstract

The invention discloses a core-shell type sericin material gold nano rod and a preparation method and applications thereof. The structure of the sericin material gold nano rod is that sericin is wrapped on the external surface of a gold nano rod. The preparation method comprises following steps: preparing a gold nano rod, which takes CTAB as the surfactant, by a seed mediating method or other synthesis methods; extracting a sericin solution with a concentration more than 0.1%; and preparing the sericin material gold nano rod by a layer-by-layer coating method. The provided method has the advantages that the cytotoxicity of the gold nano rod is largely reduced, the gold nano rod intake of cells is increased, functionalization of the gold nano rod becomes possible, the further functionalization means that sericin has many binding sites when being taken as protein, polypeptide can be grafted through a chemical method to realize precise treatment, and the gold nano rod can be co-used withnucleic acid with a drug carrying function and a curative function and a photo sensitizer to realize collaborative treatment.

Description

technical field [0001] The invention relates to a core-shell type sericin material gold nanorod and its preparation method and application, belonging to the application of sericin in the field of biomedical materials. Background technique [0002] Gold nanorods are a material with extremely high photothermal conversion efficiency, which can generate a high temperature of about 60°C under excitation light irradiation, causing cells to undergo progressive necrosis. The maximum absorption wavelength of gold nanorods is related to its aspect ratio. Through the seed-mediated method, gold nanorods with specific aspect ratios can be synthesized so that the maximum absorption wavelength falls in the near-infrared region where human tissue absorbs the least, reducing the excitation light irradiation. Damage to normal tissue. This characteristic of gold nanorods makes them good photothermal materials, which are widely used in photothermal therapy of tumors. However, the surfactant c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/64A61K41/00A61P35/00
CPCA61K41/0052A61K47/64A61P35/00
Inventor 金娜杨明英
Owner ZHEJIANG UNIV
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