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Carbon quantum dot with zwitter-ion structure on surface as well as preparation method and application of carbon quantum dot

A technology of carbon quantum dots and zwitterions, which is applied to carbon quantum dots with a zwitterionic structure on the surface and the field of preparation thereof, can solve problems such as low stability, achieve good stability, realize multi-color fluorescence imaging, and monodispersity. Good results

Active Publication Date: 2018-09-14
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to solve the technical problem that the carbon quantum dots in the prior art have low stability and cannot achieve long-term circulation in the living body under different pH conditions in the living body, the present invention provides a preparation of carbon quantum dots with a zwitterionic structure on the surface Methods and Applications

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  • Carbon quantum dot with zwitter-ion structure on surface as well as preparation method and application of carbon quantum dot
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  • Carbon quantum dot with zwitter-ion structure on surface as well as preparation method and application of carbon quantum dot

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Effect test

Embodiment 1

[0039] Carbon quantum dots with a zwitterionic structure on the surface are prepared by the following method:

[0040] Step 1: Disperse 1g of lecithin in 30mL of water.

[0041] The second step: transfer the solution to the reactor, and react at 180°C for 8 hours.

[0042] Step 3: When the reactor is cooled to 15°C, centrifuge at 12000rpm for 30min, and then filter with a 220nm filter membrane to remove the residue.

[0043] The fourth step: Freeze-drying at -60°C, with a vacuum of 8 Pa, and a drying time of 24 hours.

[0044] The prepared carbon quantum dots were characterized by a transmission electron microscope, and the test results showed that the average particle size was 2.9nm. The yield was 53.12% by the ratio of the mass of the obtained product to the mass of the reactant.

Embodiment 2

[0046] Carbon quantum dots with a zwitterionic structure on the surface are prepared by the following method:

[0047] Step 1: Disperse 1g of lecithin in 100mL of water.

[0048] The second step: transfer the solution to a reaction kettle, and react at 200°C for 24 hours.

[0049] Step 3: When the reactor is cooled to 10°C, centrifuge at 11,000rpm for 20min, and then filter with a 220nm filter membrane to remove the residue.

[0050] The fourth step: Freeze-drying at -60°C, with a vacuum of 8 Pa, and a drying time of 24 hours.

[0051] The prepared carbon quantum dots were characterized by a transmission electron microscope, and the test results showed that the average particle size was 4.3nm. The yield was 51.64% by the ratio of the mass of the obtained product to the mass of the reactant.

Embodiment 3

[0053] Carbon quantum dots with a zwitterionic structure on the surface are prepared by the following method:

[0054] Step 1: Disperse 1g of lecithin in 20mL of water.

[0055] The second step: transfer the solution to the reactor, and react at 170°C for 6 hours.

[0056] Step 3: When the reactor is cooled to 35°C, centrifuge at 14000rpm for 10min, and then filter with a 220nm filter membrane to remove the residue.

[0057] The fourth step: freeze-drying at -45°C, vacuum degree of 9Pa, and drying time of 48h.

[0058] The prepared carbon quantum dots were characterized by a transmission electron microscope, and the test results showed that the average particle size was 3.3nm. The yield of carbon quantum dots was 53.99% by the ratio of the mass of the obtained product to the mass of the reactant.

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Abstract

The invention provides a carbon quantum dot with a zwitter-ion structure on the surface as well as a preparation method and application of the carbon quantum dot. The preparation method comprises thefollowing specific steps: grinding lecithin into powder and then dispersing the powder into water to obtain a dispersed lecithin solution; transferring the obtained lecithin solution into a hydrothermal reactor, heating the hydrothermal reactor for certain time, naturally cooling and taking out to obtain a brown coarse solution; centrifuging the obtained brown coarse solution and filtering to remove residues, thus obtaining a brown clear solution; carrying out freeze drying on the obtained brown clear solution to obtain the carbon quantum dot. The technical problems that the carbon quantum dotin the prior art has lower stability and cannot realize long-term circulation in a living organism under the condition of different pH values are solved. The preparation method disclosed by the invention is simple and feasible and low in cost; the prepared carbon quantum dot has the advantages of good stability, uniform particle size distribution, good monodispersity and the like; the carbon quantum dot can be applied to nano-carriers of drugs, in particular to antitumor drugs and achieves treatment purpose.

Description

technical field [0001] The invention belongs to the technical field of fluorescent carbon nanometer materials, and in particular relates to a carbon quantum dot with a zwitterionic structure on the surface and a preparation method and application thereof. Background technique [0002] Molecules with zwitterionic structure are a class of molecules containing zwitterionic groups or anion and cation groups. The positive and negative charges of such substances are distributed on the same monomer. The surface modification of nanomaterials can maintain the stability of nanoparticles and inhibit the non-specificity of proteins. Heterotropic adsorption to achieve long-term stable circulation in the body. The zwitterionic interface with the biomimetic structure of the cell membrane can form a high-efficiency hydration layer through ion electrostatic interaction, which can not only effectively enhance the stability and anti-immune clearance ability of nanoparticles, but also enhance i...

Claims

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Application Information

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IPC IPC(8): C09K11/65C09K11/02B82Y20/00B82Y30/00B82Y40/00A61K9/51A61K47/04A61K31/704A61P35/00
CPCA61P35/00A61K9/5115A61K31/704C09K11/025C09K11/65B82Y20/00B82Y30/00B82Y40/00
Inventor 周宁琳吴凡张明袁平池铖楚晓红孙宝宏张启成
Owner NANJING NORMAL UNIVERSITY
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