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Calamine hemostatic compound based on Y molecular sieve carrier and preparation thereof

A molecular sieve and calamine technology, applied in the field of biomedical materials, can solve the problems of inflammation and local vasodilation, unfavorable wound hemostasis healing, bacterial infection, etc., and achieve high hemostatic performance, good biosafety, prothrombin time improved effect

Active Publication Date: 2021-11-09
SHANXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Furthermore, the wound surface is exposed to the air, and there is a risk of bacterial infection, which will cause inflammation and local blood vessel expansion, which is not conducive to wound hemostasis and healing, and there is also the possibility of concurrent inflammation during the wound recovery period

Method used

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  • Calamine hemostatic compound based on Y molecular sieve carrier and preparation thereof
  • Calamine hemostatic compound based on Y molecular sieve carrier and preparation thereof
  • Calamine hemostatic compound based on Y molecular sieve carrier and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Add 30mL of deionized water, 2.33g of sodium hydroxide, 0.2g of sodium chloride, 1.99g of sodium metaaluminate, and 4.33mL of 40% silica sol into a container lined with polytetrafluoroethylene, and stir for 60 minutes at room temperature.

[0040] Afterwards, the container was placed in a water bath at 25°C, stirred at a constant temperature for 24 hours, then the temperature of the water bath was raised to 45°C, stirred at a constant temperature for 24 hours, and finally the temperature was raised to 60°C and stirred at a constant temperature for 12 hours, then the stirring was stopped.

[0041] Add a layer of medical absorbent cotton and sprinkle a layer of calamine, add 1.5g of medical absorbent cotton torn into fiber sheets and 0.2g of calamine into a container with a polytetrafluoroethylene liner, put it into a stainless steel reaction The kettle was sealed, and heated to 100°C in a constant temperature box for 24 hours of constant temperature crystallization reacti...

Embodiment 2

[0057] Add 35mL of deionized water, 1.285g of sodium hydroxide, 0.2g of sodium chloride, 1.99g of sodium metaaluminate, and 2.33g of white carbon black in sequence in a container lined with polytetrafluoroethylene, and stir for 60 minutes at room temperature.

[0058] Afterwards, the container was placed in a water bath at 25°C, stirred at a constant temperature for 24 hours, then the temperature of the water bath was raised to 45°C, stirred at a constant temperature for 24 hours, and finally the temperature was raised to 60°C and stirred at a constant temperature for 12 hours, then the stirring was stopped.

[0059] Add a layer of medical absorbent cotton and sprinkle a layer of calamine, add 1.5g of medical absorbent cotton torn into fiber sheets and 0.27g of calamine into a container with a polytetrafluoroethylene liner, put it into a stainless steel reaction The kettle was sealed, and heated to 100°C in a constant temperature box for 24 hours of constant temperature crystal...

Embodiment 3

[0062] Add 32mL of deionized water, 1.8g of sodium hydroxide, 0.2g of sodium chloride, 3.41g of sodium metaaluminate, and 9.7mL of 40% silica sol into a container lined with polytetrafluoroethylene, and stir for 60 minutes at room temperature.

[0063] Afterwards, the container was placed in a water bath at 25°C, stirred at a constant temperature for 24 hours, then the temperature of the water bath was raised to 45°C, stirred at a constant temperature for 24 hours, and finally the temperature was raised to 60°C and stirred at a constant temperature for 12 hours, then the stirring was stopped.

[0064] Add a layer of medical absorbent cotton and sprinkle a layer of calamine, add 1.0g of medical absorbent cotton torn into fiber sheets and 0.15g of calamine into a container with a polytetrafluoroethylene liner, put it into a stainless steel reaction The kettle was sealed, and heated to 100°C in a constant temperature box for 24 hours of constant temperature crystallization reactio...

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Abstract

The invention discloses a calamine hemostatic compound based on a Y molecular sieve carrier. The calamine hemostatic compound is prepared by continuously stirring alkaline aqueous solution which is used for preparing a Y molecular sieve and contains a silicon source, a sodium source and an aluminum source in at least three temperature stages from the normal temperature to 60 DEG C for a certain time to obtain a molecular sieve precursor solution forming a crystal nucleus, then adding cotton fibers and calamine, heating to 90-100 DEG C in a closed reaction kettle and performing a crystallization reaction to obtain the hemostatic compound which synthesizes the Y molecular sieve on the cotton fibers and loads the calamine medicine in situ. According to the invention, by compounding multiple hemostatic materials of the Y molecular sieve, the calamine and the cotton fibers, a hemostatic material which is rapid in hemostasis, better in coagulation performance and obviously shortened in thromboplastin time is obtained, and the calamine hemostatic compound can be used as an external hemostatic material to be applied to hemostatic treatment of various wounds.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a medical hemostatic material, in particular to a hemostatic compound obtained by compounding multiple hemostatic materials and a preparation method thereof. Background technique [0002] Hemorrhage from trauma is an extremely common condition in daily emergencies, medical treatment, and military warfare. Researchers at home and abroad have conducted many studies on rapid hemostasis materials. In the earlier period, non-absorbable materials were mainly used to care for wounds, such as natural or artificial gauze and bandages. [0003] In recent years, researchers have started with substances with low cost and fast hemostasis rate, obtained hemostatic dressings with improved performance through modification, or obtained composite hemostatic materials with high biological safety or antibacterial properties through combination with other substances. [0004] Many scholar...

Claims

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Application Information

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IPC IPC(8): A61L24/02A61L24/08A61L24/00C01B39/24
CPCA61L24/0068A61L24/0015C01B39/24A61L2400/04A61L2300/102A61L2300/418A61L2300/404C01P2002/72C01P2004/03
Inventor 王颖莉张丽丽杨冬花张馨予王家信刘凯丽王艳
Owner SHANXI UNIV OF CHINESE MEDICINE
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