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Zwitterionic modified oxidized regenerated cellulose absorbable hemostatic material and preparation method thereof

A technology of regenerated cellulose and zwitterion, applied in absorbent pads, medical science, bandages, etc., can solve the problems of slow hemostasis, limited number of carboxyl groups, cytotoxicity, etc., to improve the use efficiency, improve hemostasis performance, and expand the scope of application Effect

Active Publication Date: 2013-12-04
WEIHAI JIERUI MEDICAL PRODUCTS CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The present invention aims to solve the problem of the limited number of carboxyl groups in the existing material structure, resulting in relatively slow hemostatic speed and cytotoxicity, and provides zwitterion-modified oxidized regenerated cellulose absorbable hemostatic material and its preparation method

Method used

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Examples

Experimental program
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Effect test

specific Embodiment approach 1

[0022] Specific embodiment 1: In this embodiment, the zwitterion-modified oxidized regenerated cellulose absorbable hemostatic material is composed of oxidized regenerated cellulose, 1,6-adipic acid isocyanate, N,N-dimethylethanolamine, propane sultone, It is prepared from dibutyltin dilaurate and toluene, and the carboxyl content in oxidized regenerated cellulose is 16% to 24%.

specific Embodiment approach 2

[0023] Embodiment 2: This embodiment is different from Embodiment 1 in that: the appearance of the oxidized regenerated cellulose is short filaments, filaments or fabrics. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0024] Specific embodiment 3: The difference between this embodiment and specific embodiment 1 is that the mass ratio of 1,6-adipic acid isocyanate to N,N-dimethylethanolamine is 2: (1~5), N,N- The mass ratio of dimethylethanolamine to propane sultone is 10: (14-15). Others are the same as in the first embodiment.

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PUM

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Abstract

The invention provides a preparation method of zwitterionic modified oxidized regenerated cellulose absorbable hemostatic material, and aims to solve the problems that the amount of carboxyl group is limited in the existing structure, thus hemostatic speed is low and cytotoxicity exists. The method includes 1, reacting with the 1, 6-adipate diisocyanate; 2, reacting with the N, N-dimethyl ethanolamine; and 3, reacting with the propane sultone. According to the zwitterionic modified oxidized regenerated cellulose absorbable hemostatic material, the zwitterionic structure is established on the surface of oxidized regenerated cellulose material, hemostatic performance of the material can be improved, cytotoxicity of the material can be optimized, and using effect of the material can be improved. The method is used for preparing the zwitterionic modified oxidized regenerated cellulose absorbable hemostatic material.

Description

technical field [0001] The invention relates to a modified oxidized regenerated cellulose hemostatic material and a preparation method thereof. Background technique [0002] Various accidents inevitably occur in daily life. During emergency treatment and operation, medical accidents or even death may be caused by massive bleeding. Therefore, local and effective rapid hemostasis of patients is very important, and effective control of bleeding and reducing bleeding time have become important measures to reduce the mortality of patients. Commonly used clinical hemostatic materials such as hemostatic gauze, hemostatic fiber, and hemostatic bandage have limitations in use, such as longer hemostasis time, easy adhesion to the wound and difficult dressing change, and powerlessness to wound infection and suppuration. Rapid hemostasis and functional hemostasis will be the development direction of hemostatic drugs in the future. [0003] Commonly used absorbable hemostatic materials...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/64
Inventor 吴亚东邹美芳黄玉东贺金梅王芳程玮璐陈晓通唐雷朱世欣
Owner WEIHAI JIERUI MEDICAL PRODUCTS CO LTD
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