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Prostate phantom and preparation method and application thereof

A prostate and phantom technology, applied in the field of medical biomimetic materials, can solve the problems of differences in prostate tissue characteristics and unsatisfactory application effects of prostate phantoms, so as to improve positioning and radiation dose evaluation, improve qualification rate, production efficiency and performance. stable effect

Active Publication Date: 2018-09-07
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to overcome the shortcomings of the above-mentioned prior art, and provide a composition for forming a prostate analog, so as to solve the problem that there is a certain difference between the existing prostate analog and real prostate tissue characteristics, resulting in unsatisfactory application effects technical issues
[0005] Another object of the present invention is to provide a prostate phantom and its preparation method and application, so as to solve the technical problem that there is a certain difference between the existing prostate phantom and the real prostate tissue characteristics, which leads to unsatisfactory application effect

Method used

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  • Prostate phantom and preparation method and application thereof
  • Prostate phantom and preparation method and application thereof
  • Prostate phantom and preparation method and application thereof

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preparation example Construction

[0039] At the same time, the embodiment of the present invention also provides a preparation method of the prostate analog. The process flow of the preparation method of the prostate analogue is as follows: figure 1 As shown, it includes the following steps:

[0040] After heat treatment of the composition for forming the prostate analog as described above, cooling and molding are performed to obtain the prostate analog.

[0041] Through the mixing process, each component can be uniformly dispersed in the solvent, and the soluble components can be dissolved to form a uniform mixture solution of the dispersion system.

[0042]In the step S03, during the heat treatment of the mixture solution, the components such as agarose and carrageenan dispersed in the mixture solution are dissolved, thereby forming a sol with a certain viscosity. In one embodiment, the temperature of the heat treatment is 90-95° C., and the time is 5-7 minutes. In a specific embodiment, the temperature of...

Embodiment 11

[0050] This embodiment provides a composition for forming a prostate analog. The composition for forming the prostate analog includes the following components:

[0051]

[0052] The present embodiment composition is prepared according to the following method:

[0053] Measure each component according to the formula of the present embodiment composition;

[0054] Add the measured gadolinium chloride powder into the measured part of the solvent to form a gadolinium chloride solution;

[0055] The gadolinium chloride solution is diluted with the remaining solvent measured;

[0056] Add the measured other components such as agarose, carrageenan, sodium chloride and sodium azide into the diluted gadolinium chloride solution, and mix uniformly to obtain the composition.

Embodiment 12

[0058] This embodiment provides a composition for forming a prostate analog. The composition for forming the prostate analog includes the following components:

[0059]

[0060] The composition of this example was prepared with reference to the method steps of Example 11.

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Abstract

The invention discloses a composition for forming a prostate phantom, the prostate phantom and a preparation method and application of the prostate phantom. The composition comprises, by weight, 0.65-0.712% of agarose, 22-22.5 micromol / kg cesium chloride, 2.5-3.5% of carrageenan, 0.1-0.3% of sodium chloride, and 0.025-0.035% of sodium azide. The prostate phantom is formed by the composition. The prostate phantom formed by the composition has the same characteristics as real human prostate tissue. The preparation method of the prostate phantom has the advantages that technological conditions are easy to control, the repeatability is good, the percent of pass and production efficiency of the prostate phantom are improved, and the prostate phantom can be applied to radion localization, radiation dose evaluation and prostate examination models.

Description

technical field [0001] The invention belongs to the technical field of medical bionic materials, and in particular relates to a composition for forming a prostate analog, a prostate analog, a preparation method and application thereof. Background technique [0002] Prostate cancer is the most common malignant tumor in the male reproductive system, and its incidence increases with age. According to reports, the mortality rate of prostate cancer in men is second only to lung cancer, ranking second in the death rate of cancer in men. At present, prostate seed implantation therapy is a safe and effective method to cure prostate cancer. During radiation seed implantation, the display and positioning of radiation seeds and the assessment of postoperative radiation dose are particularly important. However, using conventional MR imaging techniques, the implanted radioactive particles and their neighbors show a very large image of the black hole, ie negative contrast. This contrast ...

Claims

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Application Information

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IPC IPC(8): C08L5/00C08L5/12C08K3/16C08K3/28G01T1/02
CPCC08L5/00G01T1/02C08L5/12C08K3/16C08K3/28
Inventor 史彩云谢国喜纪秀全姜春香王海峰梁栋刘新郑海荣
Owner SHENZHEN INST OF ADVANCED TECH
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