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Preparation method of vonoprazan fumarate

A technology of vonoprazan fumarate and pyridine, which is applied in the field of preparation of vonoprazan fumarate, and can solve problems such as potential safety hazards, long routes, low total yield, etc.

Active Publication Date: 2018-09-07
上海中拓医药科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] There are two main disadvantages in this synthetic route: one is that when the cyano group is converted into an aldehyde group, the hydrogenation reaction using Raney nickel as a catalyst is easy to cause an explosion, and there is a huge safety hazard in industrial production; the other is that the aldehyde In the process of forming imine with methylamine and then reducing it with sodium borohydride to form Vonorazan, many impurities are greater than 0.1% after one recrystallization
[0009] 2. The synthetic route disclosed in Chinese patent CN105294653A is as follows: the route is too long, the operation is cumbersome, and the total yield is low. The reaction of o-fluorostyrene amine and 2-bromopropionaldehyde to generate intermediate (III) requires column chromatography, which is not suitable for industrialization Production

Method used

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  • Preparation method of vonoprazan fumarate
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  • Preparation method of vonoprazan fumarate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1: Preparation of Formula (5) 5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbonitrile

[0040] 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile (100g, 537.08mmole), 4-dimethylaminopyridine (9.84g, 80.56mmole), diisopropylethylamine (97.18g, 751.81mmole), acetonitrile (600ml) was added into a three-necked flask (3000ml), stirred and dissolved at 10-20°C, and then added dropwise to pyridine-3-sulfonyl chloride (114.47g, 644.5mmole) in acetonitrile (200ml) Solution, control the internal temperature of the reaction solution to not exceed 30°C, and stir at this temperature for 3 hours after the dropwise addition is completed. Then add 1N hydrochloric acid to adjust the pH value to 4-5, then add 1200ml of water, mechanically stir to crystallize, filter, and dry the solid. Add the solid to 1000ml of acetonitrile, heat at 60-70°C to dissolve, add activated carbon to decolorize, filter, mechanically stir the filtrate, add 1000ml of water drop by drop, stir and...

Embodiment 2

[0041]Example 2: Preparation of Formula (5) 5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbonitrile

[0042] 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile (100g, 537.08mmole), 4-dimethylaminopyridine (10.82g, 88.616mmole), diisopropylethylamine (92.32g, 714.21mmole), acetonitrile (700ml) was added to a three-necked flask (3000ml), stirred and dissolved at 10-20°C, and then added dropwise to pyridine-3-sulfonyl chloride (120.19g, 676.73mmole) in acetonitrile (300ml) Solution, control the internal temperature of the reaction solution to not exceed 30°C, and stir at this temperature for 3.5 hours after the dropwise addition is completed. Then add 1N hydrochloric acid to adjust the pH value to 4-5, then add 1100ml of water, mechanically stir and crystallize, filter, and dry the solid. Add the solid to 1100ml of acetonitrile, heat to 60-70°C to dissolve, add activated carbon to decolorize, filter, mechanically stir the filtrate, add 1100ml of water drop by drop, stir ...

Embodiment 3

[0043] Example 3: Preparation of Formula (4) 5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde

[0044] 5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbonitrile (150g, 458.2mmole), tetrahydrofuran (600ml), acetic acid (390g), water (600ml ), pyridine (750g) into a 5L three-necked flask, stirred to dissolve, then added Raney nickel (wet weight 75g), the reaction temperature was 15-25°C, stirred and added sodium hypophosphite (300g). After addition, react for 4 hours, filter, separate layers, the lower layer is the water layer, discard, the upper liquid is the organic layer, and concentrate under reduced pressure at 80°C to about 600ml, add 600ml of water and 600ml of ethyl acetate to the concentrated solution, and separate the organic layer. layer, and the aqueous layer was extracted with 240 ml of ethyl acetate, and the combined organic layers were concentrated under reduced pressure at 80°C. When the liquid cannot be concentrated, add 240ml o...

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Abstract

The invention relates to a preparation method of vonoprazan fumarate, belonging to the technical field of preparation of a raw material medicine. The preparation method of the vonoprazan fumarate comprises the following steps: 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile is used as a starting material to react with pyridine-3-sulfonyl chloride to form 5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrole-3-nitrile; the 5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrole-3-nitrile is reduced to prepare 5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrole-3-formaldehyde; then vonoprazan is prepared; and then a salt formation step is used to prepare the vonoprazan fumarate. The preparation method is suitable for industrial production.

Description

technical field [0001] The invention relates to a preparation method of vonoprazan fumarate, which belongs to the technical field of raw material medicine preparation. Background technique [0002] Vonoprazan fumarate is a new class of potassium ion (K+) competitive acid blocker (P-CAB) developed by Takeda Pharmaceutical Co., Ltd. , by inhibiting the binding of K+ to H+-K+-ATPase (proton pump), the secretion of gastric acid is terminated in advance, and it has a strong and lasting inhibitory effect on gastric acid secretion. Vonoprazan fumarate has a new target, enters the stomach at a high concentration, and can produce the largest inhibitory effect after the first administration, which can last for 24 hours. Vonoprazan fumarate is stable in acid, has a fast onset of action and a long duration of action. [0003] Wonorazan fumarate, chemical name: 1-[5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrol-3-yl]-N-methylformazan Amine monofumarate, the structure of which is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D401/12
CPCC07D401/12
Inventor 王立新左正泉彭涛汪娟
Owner 上海中拓医药科技有限公司
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