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Tissue repair scaffold, as well as preparation method and usage thereof

A tissue repair and composite fiber technology, applied in the field of biomedical devices and their preparation, can solve the problems of insufficient connection of different interface layers, weak binding force, large shrinkage, etc., to achieve easy control of product quality, short production time, lightening effects of trauma

Active Publication Date: 2018-09-04
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the process is complicated, and the connection between different interface layers is not tight enough, and the hydrophobic or hydrophilic surface in contact with the tissue still has the above-mentioned weak binding force with the tissue or large shrinkage after absorbing water.

Method used

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  • Tissue repair scaffold, as well as preparation method and usage thereof
  • Tissue repair scaffold, as well as preparation method and usage thereof
  • Tissue repair scaffold, as well as preparation method and usage thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0048] The preparation method of the tissue repair scaffold is characterized in that, the adhesion factor and the hydrophobic synthetic material are dissolved in the same solvent, and then through electrospinning technology, centrifugal spinning technology, hot-melt spinning technology, melting electrospinning technology One or more combinations of spinning techniques are used to obtain the surface containing the composite fiber. Among them, electrospinning technology, centrifugal spinning technology, hot melt spinning technology, and melt electrospinning technology are preferably used, and centrifugal spinning technology and electrostatic spinning technology are more preferably used.

[0049] The composite fiber used in the tissue repair scaffold of the present invention can be prepared by centrifugal spinning technology. The hydrophobic synthetic material and adhesion factor can be dissolved in the same solvent at the same time to form a uniform solution. The solution enters...

Embodiment 1

[0056] Dissolve PCL and gelatin in trifluoroethanol according to the mass ratio of 10:1 to form a solution, and then the solution enters the centrifugal spinning machine through the propulsion pump, the propulsion pump propulsion speed is 150g / min, the centrifugal disc line speed is 6000m / min, the solution Fibers are spun rapidly, and the spinning temperature is 50°C. After the spinning is finished, the film is taken off from the receiving roll, and the solvent is removed by vacuum drying to obtain the composite fiber material of the scaffold.

[0057] The SEM image of the composite fiber is shown in figure 1 -A, after the composite fiber is treated in 50°C water that can dissolve gelatin but not PCL, its SEM image is shown in figure 1 -B, it can be clearly seen that the composite fiber has a composite structure of PCL and gelatin.

Embodiment 2

[0059] PLLA and chitosan are dissolved in trifluoroacetic acid according to the mass ratio of 10:9 to form a solution, and then the solution enters the centrifugal spinning machine through the propulsion pump, the propulsion speed of the propulsion pump is 100g / min, and the linear velocity of the centrifugal disc is 3000m / min , the solution is rapidly spun into fibers, and the spinning temperature is 80°C. After the spinning is completed, the film is removed from the receiving roll, and the solvent is removed by vacuum drying to obtain the composite fiber material of the scaffold.

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Abstract

The invention provides a tissue repair scaffold, as well as a preparation method and usage thereof. At least one surface of the tissue repair scaffold comprises a composite fiber which comprises an adhesion factor and a hydrophobic synthetic material. The surface comprising the composite fiber enables the tissue repair scaffold of the invention to be endowed with good tissue adhesive force and conformability and adhere well to a tissue anatomic structure. The tissue repair scaffold can be either sutured or non-sutured.

Description

[0001] This application is a divisional application of an application with a filing date of June 28, 2013, an application number of 201310269863.4, and an invention title of "tissue repair scaffold, its preparation method and application". technical field [0002] The invention relates to a biomedical device and its preparation, in particular to a tissue repair bracket, its preparation method and application. Background technique [0003] Tissue repair scaffolds are very common in clinical work, such as tendon repair sheets, hernia repair sheets, dura (spinal) membrane repair sheets, pelvic floor repair sheets, and sling repair sheets. [0004] However, due to the certain defects of the existing synthetic materials, the composition elements of the materials themselves, the surface charge properties, the basic composition units of the materials, the composition structures, the hydrophilic and hydrophobic properties of the surface, and the composition units of human tissues all...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/22A61L27/18A61L27/20A61L27/24A61L27/50A61L27/56A61L27/60
Inventor 邓坤学徐弢袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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