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Quality control method of jichuan decoction composition

A quality control method and composition technology, which can be applied to measuring devices, instruments, scientific instruments, etc., can solve the problems of many components, few indicators, and single quality control, and achieve the effects of objective conclusion, convenient operation, and control of the quality of preparations.

Active Publication Date: 2018-08-28
CHINA RESOURCES SANJIU MEDICAL & PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therefore, the technical problem to be solved in the present invention is to overcome the traditional Chinese medicine compound preparations in the prior art, which basically only have one or two index components in content control, single quality control, few indexes, and it is difficult to fully reflect that there are many flavors and many components. , the defects of the quality status of the Jichuan fried composition with many targets, thereby providing a quality control method for the Jichuan fried composition

Method used

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  • Quality control method of jichuan decoction composition
  • Quality control method of jichuan decoction composition
  • Quality control method of jichuan decoction composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Example 1. Preparation of Jichuan Fried Composition

[0066] According to the following proportions, take 625g of Cistanche deserticola; 1000g of angelica; 500g of Achyranthes bidentata; 375g of Alisma alisma; Filtrate, concentrate the filtrate to a clear paste with a relative density of 1.20-1.25 (60° C.), add an appropriate amount of maltodextrin, mix well, dry, and granulate to make 1000 g of Jichuan decoction composition.

Embodiment 2

[0067] Example 2. Research on the Fingerprint of Jichuan Fried Composition

[0068] Instruments and reagents

[0069] High performance liquid chromatography: Agilent 1100Series;

[0070] Electronic analytical balance: Germany Sartorius BT25s and BS124s

[0071] Ultrasonic cleaning machine: Beijing Ultrasonic Instrument Co., Ltd.

[0072] Chromatographic column: Agilent eclipse XDB C18 column (5μm, 4.6mm×250mm);

[0073] Reagents: Acetonitrile is chromatographically pure, water is ultrapure water; other reagents are analytically pure.

[0074] Reagent: Jichuanjian Granules (batch number: 1602001J).

[0075] (1) Chromatographic conditions

[0076] Use octadecylsilane bonded silica gel as filler (column length 250mm, inner diameter 4.6mm, particle size 5μm); use acetonitrile as mobile phase A, 0.1% phosphoric acid solution as mobile phase B, and carry out as specified in the following table Gradient elution. The flow rate is 1.0ml per minute; the column temperature is 30°C...

Embodiment 3

[0110] Example 3. Determination of Echinacoside, Ferulic Acid, Isoferulic Acid, and Neohesperidin Contents in the Jichuan Decoction Composition by High Performance Liquid Chromatography

[0111] Instruments and materials

[0112] (1) Main instrument Agilent1100 high performance liquid chromatography: diode array detector, quaternary low-pressure gradient pump, vacuum degasser, column thermostat, automatic sampler; data processor: Agilent1100 chromatography workstation; ten-thousandth electronic Analytical balance (BS 110S, Sartorius, USA); 1 / 100,000 electronic analytical balance (BP 211D, Sartorius, USA); ultrasonic cleaner.

[0113] (2) Experimental materials

[0114] Reagents: analytical grade methanol (Beijing Chemical Plant); chromatographic grade acetonitrile (Tianjin Biaoshiqi Technology Development Co., Ltd.); self-made redistilled water (Robust pure water obtained by distillation in an automatic double pure water still).

[0115] Chromatographic column: Agilent Eclip...

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Abstract

The invention discloses a quality control method of a jichuan decoction composition, wherein the method belongs to the field of traditional Chinese medicine analysis. The method comprises establishinga jichuan decoction composition fingerprint atlas according to high-efficiency liquid chromatography. Chromatogram conditions are characterized in that a chromatographic column is an octadecylsilanechemically bonded silica chromatographic column; the detecting wavelength is 320nm; the flow velocity is 0.9-1.1ml / min; the column temperature is 25-35 DEG C; a theoretical plate number is not lower than 5000 when calculated according to a ferulic acid peak; acetonitrile (A)-0.1% phosphoric acid solution (B) is used as a mobile phone; and gradient elution is performed according to a sequence whichis shown in the description. Therefore the quality control method realizes a purpose of more comprehensively and effectively controlling the quality of a jichuan decoction composition product.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine analysis, and relates to a quality standard detection method for traditional Chinese medicine compound granules. Background technique [0002] Traditional Chinese medicine decoction is the mainstream of clinical medicine, but because of decoction and inconvenient to carry, the quality of the decoction prepared by decoction often varies greatly depending on the person and the decoction utensils. The use of modern science and technology to develop traditional Chinese medicine preparations that are easy to carry and easy to take is not only the inheritance of traditional Chinese medicine, but also a better promotion of classic famous prescriptions. Clinical application. The preparation process of granules is relatively simple, easy to shape, easy to take and carry, and the form of taking is most consistent with traditional decoctions, and can maintain the characteristics of traditional de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 林丽娜郭小芳刘志刚陈周全谭沛马鹏岗曾祥腾高云佳屠鹏飞
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
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