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A kind of compound maltodextrin and its preparation method and application

A maltodextrin and cyclodextrin technology, which is used in pharmaceutical formulations, non-active components of polymer compounds, and medical preparations with non-active components, etc., can solve problems such as inability to granulate, mottle, and granules become burnt black. , to achieve the effect of improving the sticking phenomenon, high molding rate, convenient storage and use

Active Publication Date: 2021-06-11
NINGBO LIWAH PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, due to the properties of unilateral granules such as rehmannia glutinosa, rehmannia glutinosa, angelica, and Chuanqiong, when dry-compressing granules using the above method, maltodextrin with a degree of hydrolysis expressed as 16-20 is added as an auxiliary material, and the obtained granules Burnt black or severe mottling, resulting in failure to granulate

Method used

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  • A kind of compound maltodextrin and its preparation method and application
  • A kind of compound maltodextrin and its preparation method and application
  • A kind of compound maltodextrin and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-5

[0030] The moisture dextrin having a hydrolysis of less than 11 in accordance with the number of parts of Table 1-5, a maltodextrin having a hydrolysis of 11-15 and a microcrystalline cellulose mixed with a microcarrobe, and a hydrolysis of 16-20 was added. After mixing, mixed with dextrin and mixed with lactose and β-cyclosils to mix the composite maltodextrin.

Embodiment 6

[0031] Example 6: Chinese medicine particles

[0032] The composite maltodextrin obtained in Example 1 was added to the Chinese medicine after extracting concentrated drying, and the mixture was mixed, and the dry method was mixed, in which the Chinese medicine dipper powder was pretreated with Chinese medicine dipper powder, the pretreated Chinese medicine The processing includes the following steps: the gelatin is dissolved in distilled water, and the traditional Chinese medicine dipper is stirred, heat insulation is for use; the tray 60 and Tween 60 are dissolved in liquid paraffin, and the drug-containing gelatin is added, stirred after stirring to -3 ° C, The addition of 2.3% of glutaraldehyde and isopropyl alcohol was added, and filtered after heat preservation, washed dried, wherein the mass ratio of the gelatin and the mass ratio of the Chinese medicine extract was 1: 1.

Embodiment 7

[0033] Example 7: Chinese medicine particles

[0034] The difference from Example 6 is to be added to the composite maltodextrin obtained in Example 2, and after the addition of pharmaceutical gelatin is added, stirred after stirring to -3.5 ° C, and the concentration of 2.35% glutaraldehyde and The mass ratio of isopropanol and gelatin and the mass ratio of Chinese medicine dipper is 1: 5.

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Abstract

The invention relates to a compound maltodextrin and its preparation method and application, which is suitable for dry-compression granulation of rehmannia glutinosa, raw rehmannia glutinosa, angelica, Chuanqiong and other granules or compound granules containing these medicinal flavors, or in solid beverages , belonging to the field of composite raw materials. The compound maltodextrin comprises the following components in parts by weight: 0-30 parts of maltodextrin with a degree of hydrolysis of less than 11, 0-30 parts of maltodextrin with a degree of hydrolysis of 11-15, and 0-30 parts of maltodextrin with a degree of hydrolysis of 16-20. Maltodextrin 0-30 parts, lactose 0-15 parts, β-cyclodextrin 0-5 parts, microcrystalline cellulose 0-5 parts. The present invention can reduce the content of reducing sugar in the mixed maltodextrin by using three kinds of maltodextrins with different degrees of hydrolysis, thereby overcoming the browning reaction of amino acids in rehmannia glutinosa, rehmannia glutinosa, angelica, and Chuanqiong, resulting in the prepared Particles become burnt black or severely mottled, and cannot be granulated.

Description

[0001] Invention [0002] The present invention relates to a composite maltodextrin and a preparation method thereof, suitable for cooler yellow, residential yellow, angelica, Chuan sect, oriented, compound granules containing these medicinal particles, or applied to solid beverages It belongs to the field of composite raw materials. Background technique [0003] Chinese medicine formula granules are the results of traditional Chinese medicine drinking dosage forms. It is the traditional Chinese medicine granules made from Chinese herbal medicines, using process made of extraction, concentration, drying, granulation, etc., can be used in clinical Chinese medicine flexible components, is a new Chinese medicine medicine select. [0004] At present, the granulation process of traditional Chinese medicine formulation particles is mainly used for dry method. However, some varieties such as rhizospheres such as starch, fatty oil, mucidal, animal protein, etc., fruit seed and animal Chine...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K47/36A61K47/26A61K47/38A61K47/40A61K36/804A61K36/232A61K36/236A23L2/39A23L2/52
CPCA23L2/39A23L2/52A61K9/1623A61K9/1652A61K36/232A61K36/236A61K36/804
Inventor 周海滨江海龙陈旦凤陈斌徐旭峰
Owner NINGBO LIWAH PHARM CO LTD
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