A bisphosphonate drug-intercalated hydrotalcite medical magnesium alloy coating and its preparation method and application

A bisphosphonate and hydrotalcite technology, applied in coatings, medical science, prostheses, etc., to achieve the effect of strong coating binding force, improved compactness and corrosion resistance, and clear structure

Active Publication Date: 2021-02-02
TIANJIN UNIVERSITY OF TECHNOLOGY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the technical problems that the degradation rate of medical magnesium alloys is too fast and functionalization such as antibacterial and bone proliferation needs to be promoted, the present invention provides a method for preparing a bisphosphonate drug-intercalated hydrotalcite medical magnesium alloy coating. The bisphosphonate drug / nano-silver dual-functional coating obtained by the preparation method provided by the invention has a compact structure, good corrosion resistance, and has antibacterial and bone proliferation-promoting properties at the same time

Method used

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  • A bisphosphonate drug-intercalated hydrotalcite medical magnesium alloy coating and its preparation method and application
  • A bisphosphonate drug-intercalated hydrotalcite medical magnesium alloy coating and its preparation method and application
  • A bisphosphonate drug-intercalated hydrotalcite medical magnesium alloy coating and its preparation method and application

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preparation example Construction

[0031] The invention provides a method for preparing a bisphosphonate drug-intercalated hydrotalcite medical magnesium alloy coating, comprising the following steps:

[0032] Aluminum nitrate, silver nitrate and water are prepared into solution A;

[0033] Bisphosphonate and water are prepared as Solution B;

[0034] After mixing solution A and solution B, adjust the pH value to 11.5-12.5 to obtain a precursor emulsion;

[0035] The Mg alloy substrate and the precursor emulsion are hydrothermally reacted at 110-125° C. for 10-24 hours to obtain bisphosphonate drug-intercalated hydrotalcite medical magnesium alloy coating.

[0036]In the present invention, there is no special requirement for the preparation sequence of solution A and solution B, which can be carried out simultaneously or separately.

[0037] In the present invention, aluminum nitrate, silver nitrate and water are formulated into solution A. In the present invention, the volume ratio of the amount of aluminum...

Embodiment 1

[0080] (1) Set the surface area to 1cm 2 The magnesium alloy Mg-3Zn-0.8Zr was mechanically polished, and the surface of the sample was polished with 320#, 800#, and 1500# water-grinding sandpaper in turn to remove the oxide layer; placed in acetone and ultrasonically oscillated twice, 20 minutes / time, and then Place in absolute ethanol and ultrasonically vibrate 5 times, 10 minutes each time, and blow dry with cold air.

[0081] (2) Weigh 0.02mol Al(NO 3 ) 3 6H 2 O and 0.015mol AgNO 3 Dissolve in 100mL deionized water to make solution A.

[0082] (3) Weigh 0.005 mol of alendronate sodium and dissolve it in 100 mL of deionized water to prepare solution B. Add solution B dropwise to solution A, stir magnetically for 30 min, add 1 mol / L sodium hydroxide solution, adjust pH=12.5, and obtain precursor emulsion.

[0083] (4) The purified magnesium alloy substrate and the above precursor emulsion were placed in a hydrothermal reaction kettle, and kept at 125° C. for 10 h to car...

Embodiment 2

[0086] (1) Set the surface area to 1cm 2 The magnesium alloy Mg-3Zn-0.8Zr-0.3Sr was mechanically polished, and the surface of the sample was polished with 320#, 800#, and 1500# water-grinding sandpaper in turn to remove the oxide layer; placed in acetone and ultrasonically oscillated 5 times, 5 minutes / time, and placed in absolute ethanol for 2 times of ultrasonic vibration, 15 minutes each time, and dried with cold air.

[0087] (2) Weigh 0.01mol Al(NO 3 ) 3 6H 2 O and 0.005mol AgNO 3 Dissolve in 50mL deionized water to make solution A.

[0088] (3) Weigh 0.0005 mol of sodium alendronate and dissolve it in 100 mL of deionized water to prepare solution B. Add solution B dropwise to solution A, stir magnetically for 30 min, add 0.5 mol / L sodium hydroxide solution, adjust pH=11.5, and obtain precursor emulsion.

[0089] (4) Put the purified magnesium alloy substrate and the above-mentioned treatment in a hydrothermal reaction kettle, and heat it at 110° C. for 12 hours to...

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Abstract

The invention relates to the technical field of medical alloy coatings, and provides a bisphosphonate drug-intercalated hydrotalcite medical magnesium alloy coating, a preparation method and application thereof. In the present invention, solution A is prepared by preparing aluminum nitrate, silver nitrate and water; solution B is prepared by bisphosphonate and water; after mixing solution A and solution B, the pH value is adjusted to 11.5-12.5 to obtain the precursor emulsion; The Mg alloy substrate and the precursor emulsion are hydrothermally reacted at 110-125° C. for 10-24 hours to obtain bisphosphonate drug-intercalated hydrotalcite medical magnesium alloy coating. The bisphosphonate drug / nano-silver bifunctional magnesium alloy coating obtained by the preparation method of the invention has compact structure, good corrosion resistance, and excellent properties of antibacterial and bone proliferation promotion.

Description

technical field [0001] The invention relates to the technical field of medical alloy coatings, in particular to a bisphosphonate drug-intercalated hydrotalcite medical magnesium alloy coating and a preparation method and application thereof. Background technique [0002] Medical magnesium alloy has biodegradability, good biocompatibility and mechanical compatibility. Compared with implant materials such as titanium alloy in clinical application, medical magnesium alloy has obvious advantages: the elastic modulus of magnesium alloy is close to that of human bone, The "stress shielding" effect is reduced, and the mechanical compatibility is good; magnesium is an essential element for the human body, participates in human metabolism and enzymatic reactions, promotes the proliferation and differentiation of bone cells, and accelerates bone tissue healing; the low potential of magnesium endows it with Degradability, magnesium is easy to corrode and degrade in the body fluid envir...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04A61L27/28A61L27/30A61L27/32A61L27/54A61L27/50
CPCA61L27/047A61L27/28A61L27/306A61L27/32A61L27/50A61L27/54A61L2300/104A61L2300/404A61L2300/602A61L2300/606A61L2420/02A61L2430/02
Inventor 陈民芳王伟赵云李枭
Owner TIANJIN UNIVERSITY OF TECHNOLOGY
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